FARMACOCINETICA CLINICA- FCH-2 - Ramon A Enriquez Moo

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Universidad Autónoma de Campeche 
Facultad de Ciencias Quimico Biologicas 
Licenciatura en Quimico Farmaceutico Biologo 
Unidad de Aprendizaje: Farmacia Clínica Hospitalaria 
Docente: Luis A Nunez Oreza 
Expocicion de Farmacocinetica Clinica 
Equipo: 
Gerson A Alcocer Ramon 
Ramon A Enriquez Moo
Dana D Martinez Avila 
Fatima del Carmen Colli Avalos 
San Francisco de Campeche, Campeche. 
Farmacocinética de 
un Fármaco 
La amoxicilina, una penicilina semisintética sensible a la 
penicilinasa, tiene una estrecha relación con la ampicilina 
en aspectos químicos y farmacológicos. 
Propiedades Farmacoterapéutico 
Amoxicilina 
La amoxicilina es estable en ácido, diseñada para 
uso oral, y se absorbe más rápido y de manera más 
completa del tracto GI que la ampicilina. 
Las concentraciones máximas de amoxicilina en plasma 
son de 2 a 2.25 se alcanzan en un plazo de 2 h y son de 
unos 4 mg/ml cuando se administran 250 mg. 
Grupo farmacoterapeutico: Antibacterianos betalactámicos, penicilinas. 
Formula: C 16H 19N 3O 5S
Masa molecular: 365.4 g/mol 
Propiedades fisicas y quimicas
❏ Apariencia: Polvo cristalino blanco 
❏ Estado: Solido 
❏ Toxicidad: Baja 
❏ Punto de fusion: 195°C 
❏ Densidad: < 0.45 g/ ml3 
❏ Solubilidad: en agua 4.0 mg/ml.
Propiedades químicas 
Amoxicilina 
Farmacodinamia 
Amoxicilina 
Actúa inhibiendo la síntesis de la barrera de peptidoglicano de la pared 
celular bacteriana al unirse e inactivar a las enzimas implicadas en el 
proceso. 
Es un antibiótico betalactámico con actividad antimicrobiana intrínseca 
insignificante y elevada afinidad por enzimas betalactamasas 
producidas por algunas bacterias que degradan por hidrólisis a la 
amoxicilina 
Gram positivos y Gram negativas productoras y no productoras de 
betalactamasa, como: 
Gram (+): Staphylococcus aureus, 
Staphylococcus epidermidis, 
Streptococcus spp. (incluyendo 
Streptococcus pneumoniae y 
Streptococcus pyogenes) y 
Corynebacterium spp. 
Gram (-): Haemophilus influenzae, 
Haemophilus parainfluenzae, Moraxella 
catarrhalis, Klebsiella spp., Enterobacter 
spp., Neisseria gonorrhoeae, Pasteurella 
mutocida, Escherichia coli, Proteus 
mirabilis, Salmonella spp. y Shigella spp. 
Farmacocinetica 
Amoxicilina 
Se absorben bien y casi completamente en el tracto gastrointestinal, 
alcanzando concentraciones plasmáticas pico a las 1-2.5 horas de su 
administración oral. 
Proteínas plasmáticas en un 17-20%
Se metaboliza parcialmente por hidrólisis al ácido penicílico que se 
excreta, junto a un 50-75% de fármaco inalterado, por la orina 
mediante secreción tubular y filtración glomerular, y en muy escasa 
proporción por las heces. 
La vida media de eliminación es de 1 hora. 
Mercury
It’s the closest planet to the 
Sun and the smallest one in 
the Solar System
Venus
Venus has a beautiful name 
and is the second planet 
from the Sun
IMPORTANT GOALS
Mars
Despite being red, Mars is 
actually a cold place. It’s full 
of iron oxide dust
—SOMEONE FAMOUS
“This is a quote, words full of wisdom that 
someone important said and can make the 
reader get inspired.”
6,100,982
people over 65 years of age, is the source population included in this study
1,876,821
individuals were excluded because they 
were hospitalized 
1,216,541
individuals were excluded because they were not prescribed 
any medication 
3,007,620
individuals that were engaged for this 
final study
BACKGROUND
Jupiter is the biggest planet 
of them all
Main risk
Mercury is the closest planet 
to the Sun
Side effects
Venus is the second planet 
from the Sun
Decisive factors Prevalence
Saturn is composed of 
hydrogen and helium
Risks
 Mars is actually a very cold 
place
Outcomes
Neptune is the farthest 
planet from the Sun
DECISIVE FACTORS
Decisive
Age - Gender
Smoking
Socioeconomic status
Occupation
Education
Physical activity
Prevalence
Polypharmacy
Health conditions
Outcomes
Hospital admission
ADR
Fall
Malnutrition
Cognitive impairment
Mortality
RESEARCH AND PUBLICATIONS
Internal Medicine Journal
Jupiter is a gas giant and the biggest planet in the Solar System. It's the 
fourth-brightest object in the night sky
Journal of Pharmacy Practice and Research
Venus has a beautiful name and is the second planet from the Sun. It’s 
hot and has a poisonous atmosphere
International Journal of Pharmacy 
Mercury is the closest planet to the Sun and the smallest one in the 
Solar System—it’s only a bit larger than the Moon
RESEARCH RESOURCES
Do you know what helps you make your point 
clear?
Lists like this one:
● They’re simple 
● You can organize your ideas clearly
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And the most important thing: the audience won’t 
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AWESOME 
WORDS
FACTORS TO CONSIDER
Definition of 
polypharmacy
Excessive 
polypharmacy
Mercury is the closest planet to the 
Sun and the smallest one in the Solar 
System
Venus has a beautiful name and is 
the second planet from the Sun. It’s 
hot and has a poisonous atmosphere
LEARN ABOUT 
POLYPHARMACY
CLINICAL TRIAL
older adults (≥60 years)
Age
25 participants
Sample
sedative medication
Group 1
exposed to polypharmacy
Group 2
6 months
Experiment time Neptune is far away from Earth
Effects
Saturn is a gas giant 
with several rings
Results
Check side effects
Goal
Research
TRIAL TIMELINE
1
Saturn is a gas giant 
with several rings
Preclinical
2
Venus is the second 
planet from the Sun
Experiment
3
Jupiter is the biggest 
planet of them all
Result
4
Mars is actually a very 
cold place
POLYPHARMACY GROWTH BY AREA 
Mercury is the closest 
planet to the Sun and the 
smallest one in our System
Up to 15%
Up to 50%
Up to 75%
MOST COMMON DRUG COMBINATION
Antihypertensives
Venus is the second planet 
from the Sun
Antidepressant
It’s the biggest planet in the Solar 
System
Painkillers
Despite being red, Mars is a 
cold place
Antianxiolytic
Saturn is a gas giant and has 
several rings
TREND
Follow the link in the graph to modify its data and then paste the new one here. For more info, 
click here
Jupiter is the biggest 
planet of them all
Group 1
Mercury is the closest 
planet to the Sun
Group 2
https://docs.google.com/spreadsheets/d/1QJwFRwc0pOj_xpWihJ2IQMlke8xKC7t_rGCi1fodXfQ/copy
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RESULTS
Results Group 1 Group 2
Improved 60% 10%
Worsened 30% 80%
Unchanged 10% 10%
Side effects none many
RESULTS ANALYSIS
Group 2
Venus is the second planet from the Sun
Headache
Dizziness
Confusion
Group 1
Venus is the second planet from the Sun
Headache
Dizziness
Confusion
60%
50%
80%
60%
60%
20%
A PICTURE 
ALWAYS 
REINFORCES 
THE 
CONCEPT
Images reveal large amounts of data, 
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of a long text. Your audience will 
appreciate it
SUCCESS RATE
Group 2
Group 1
30%
70%
Venus has a beautiful name and is the second planet 
from the Sun
Mercury the closest planet to the Sun and the smallest 
one in the Solar System
CONCLUSION
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entire Solar System
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