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What are the indications, precautions, therapeutic scheme, and adverse effects of the following thrombolytic drugs: Tirofiban, Activadores tisulare...

What are the indications, precautions, therapeutic scheme, and adverse effects of the following thrombolytic drugs: Tirofiban, Activadores tisulares del plasminógeno (rt-PA), Estreptoquinasa, Tenecteplasa (TNK-tPa), and Uroquinasa?
Indications
Precautions
Therapeutic scheme
Adverse effects
Tirofiban is indicated for short-term prevention of myocardial infarction in patients with unstable angina or non-Q-wave myocardial infarction. It is contraindicated in patients with ischemic stroke within the previous 30 days or hemorrhagic stroke, intracranial pathology (neoplasm, AVM, aneurysm), recent clinically relevant bleeding, malignant hypertension, significant trauma or major surgery within the previous 6 weeks, thrombocytopenia (platelet count <100,000/mm3), alterations in platelet function, alterations in coagulation (PT>1.3 times normal or INR>1.5), severe hepatic insufficiency, and active peptic ulcer. It should be used with caution in elderly and underweight subjects due to a relatively higher incidence of bleeding. It should also be used with caution in subjects with reduced renal function (creatinine clearance <60 ml/min).
Activadores tisulares del plasminógeno (rt-PA) is indicated for coronary thrombus lysis in the course of acute transmural myocardial infarction, preferably starting within 6 hours after the onset of symptoms, and for confirmed massive acute pulmonary embolism, especially in subjects with hemodynamic stability. It is contraindicated in patients with ongoing bleeding, previous stroke, cerebral event or trauma in the last 60 days, major surgery or trauma in the last 15 days, coagulopathy or hemorrhagic diathesis, arterial hypertension (>180/110 mmHg) resistant to treatment, current therapy with warfarin with INR > 2.5, aortic dissection. It should be used with caution in peptic ulcer under treatment, previous stroke, recent major surgery or trauma (>15 days <2 months), CPR maneuvers for cardiac arrest in the last 10 days, suspected rib fracture, hemorrhagic retinopathy or recent intervention in the retina with laser, pregnancy, severe liver or kidney disease, atrial fibrillation.
Estreptoquinasa is indicated for thrombus lysis in the course of acute transmural myocardial infarction, preferably starting within 6 hours after the onset of symptoms, and for confirmed massive acute pulmonary embolism. It is contraindicated in patients with active bleeding, previous stroke, cerebral event or trauma in the last 60 days, major surgery or trauma in the last 15 days, coagulopathy or hemorrhagic diathesis, arterial hypertension (>180/110 mmHg) resistant to treatment, current therapy with warfarin with INR > 2.5, aortic dissection. It should be used with caution in peptic ulcer under treatment, previous stroke, recent major surgery or trauma (>15 days <2 months), CPR maneuvers for cardiac arrest in the last 10 days, suspected rib fracture, hemorrhagic retinopathy or recent intervention in the retina with laser, pregnancy, severe liver or kidney disease, atrial fibrillation.
Tenecteplasa (TNK-tPa) is indicated for thrombus lysis in the course of acute transmural myocardial infarction, preferably starting within 6 hours after the onset of symptoms. It should be used with caution in patients with previous stroke, recent major surgery or trauma, recent CPR maneuvers for cardiac arrest, suspected rib fracture, hemorrhagic retinopathy or recent intervention in the retina with laser, pregnancy, severe liver or kidney disease, atrial fibrillation. It should not be administered in a line containing dextrose.
Urokinase is indicated for thrombus lysis in the course of acute transmural myocardial infarction, preferably starting within 6 hours after the onset of symptoms, and for confirmed massive acute pulmonary embolism. It should be used with caution in patients with previous stroke, recent major surgery or trauma, recent CPR maneuvers for cardiac arrest, suspected rib fracture, hemorrhagic retinopathy or recent intervention in the retina with laser, pregnancy, severe liver or kidney disease, atrial fibrillation.
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