What are the indications, pharmacology, side effects, and administration of the following drugs: a) Enalapril, b) Temsirolimus, c) Obinutuzumab, d) Rituximab, e) Ado-trastuzumab emtansina, and f) Ibritumomab tiuxetán?
a) Indications, pharmacology, side effects, and administration of Enalapril
b) Indications, pharmacology, side effects, and administration of Temsirolimus
c) Indications, pharmacology, side effects, and administration of Obinutuzumab
d) Indications, pharmacology, side effects, and administration of Rituximab
e) Indications, pharmacology, side effects, and administration of Ado-trastuzumab emtansina
f) Indications, pharmacology, side effects, and administration of Ibritumomab tiuxetán
i. Enalapril is indicated for hypertension and heart failure.
ii. Temsirolimus is an mTOR inhibitor that reduces protein synthesis and cell proliferation.
iii. Obinutuzumab is a humanized MAb that induces complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity.
iv. Rituximab is a chimeric murine/human MAb that induces complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity.
v. Ado-trastuzumab emtansina is a humanized MAb conjugated with DM1, which inhibits microtubules and induces cell cycle arrest and apoptosis.
vi. Ibritumomab tiuxetán is a radioimmunoconjugate MAb that induces cytotoxicity and apoptosis through the emission of radiation.
a) i, ii, and iv are correct.
b) ii, iii, and v are correct.
c) iii, iv, and vi are correct.
d) i, iii, and v are correct.
e) ii, iv, and vi are correct.
f) i, iii, and vi are correct.