Ciclo de Krebs - Dariel Isai Soria Cordova

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Ciclo de Krebs
Cadena respiratoria 
fosforilación oxidativa
3
Ciclo de Krebs
Ciclo de Krebs
5
Ciclo de Krebs
Ciclo de Krebs
8
9
10
Citric acid cycle
Citrate
Succinyl-CoA
synthetase
Aconitase
Citrate synthase
Succinate
dehydrogenase
GTP
GDP
Oxaloacetate
Pyruvate
Aconitase
Isocitrate
dehydrogenase
Isocitrate
dehydrogenase
-Ketoglutarate
dehydrogenase
Succinyl-CoA
-Ketoglutarate
Malate
dehydrogenase
Pyruvate
dehydrogenase
Fumarase
cis-Aconitate
Isocitrate
Oxalosuccinate
Succinate
Fumarate
Malate
FAD
FADH2
NAD
NADH
CO2
NAD
NADH
CO2
NAD
NADH
H2O
H2O
H2O
NAD
NADH
CO2
12
Citric acid cycle
Citrate
Succinyl-CoA
synthetase
Cis-Aconitase
Citrate synthase
Succinate
dehydrogenase
GTP
GDP
Oxaloacetate
Pyruvate
Cis-Aconitase
Isocitrate
dehydrogenase
Isocitrate
dehydrogenase
-Ketoglutarate
dehydrogenase
-Ketoglutarate
Malate
dehydrogenase
Pyruvate
dehydrogenase
Fumarase
cis-Aconitate
Isocitrate
Oxalosuccinate
Succinate
Fumarate
Malate
FAD
FADH2
NAD
NADH
CO2
NAD
NADH
CO2
NAD
NADH
H2O
H2O
H2O
NAD
NADH
CO2
CO2
Pyruvate
carboxylase
Succinyl-CoA
Acetyl-CoA
 
13
Energía libre de Gibs
Regulación del ciclo de Krebs
15
Vía anaplerótica
17
Vía anaplerótica
18
Complejo I y II
23
Complejo I
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25
28
4
30
32
https://www.youtube.com/watch?v=3y1dO4nNaKY&t=56s
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Succinate:CoQ
Oxidoreductase
(Complex II)



b
 
 



Mitochondrial
Matrix
Cyt c
Cyt bc1
Cyt bc1
COX
COX
NADH:CoQ
Oxidoreductase
(Complex I)
Mitochondrial electron transport and oxidative phosphorylation
CoQ:Cytochrome c
Oxidoreductase
(Complex III)
Cytochrome c
Oxidase
(Complex IV)
NADH + H+
NAD
Succinate DH
(FAD)
Succinate
Fumarate
H+
H+
H+
ADP + Pi
ATP
H+
Q
C C C 
a
2 e-
Q
Q
Q
Q
41
Q
Q
Q
Succinate:CoQ
Oxidoreductase
(Complex II)



b
 
 



Mitochondrial
Matrix
Cyt c
Cyt bc1
Cyt bc1
COX
COX
NADH:CoQ
Oxidoreductase
(Complex I)
CoQ:Cytochrome c
Oxidoreductase
(Complex III)
Cytochrome c
Oxidase
(Complex IV)
NADH + H+
NAD
Succinate DH
(FAD)
Succinate
Fumarate
H+
H+
H+
ADP + Pi
ATP
H+
C C C 
a
Rotenone
Amytal
Inhibitors of electron transport and oxidative phosphorylation
Antimycin A
Oligomycin
2 e-
Q
Q
OSCP
42
https://www.youtube.com/watch?v=xbJ0nbzt5Kw
https://www.youtube.com/watch?v=rdF3mnyS1p0
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Anaeróbica
46