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xv Acknowledgments We would like to thank all the scientists, colleagues, and friends who supported us during the course of our scientific career, es- pecially Francisco Barrantes, Luc Belzunces, Pierre Burtin, Henri Chahinian, Ahmed Charaï, Caroline Costedoat, Patrick Cozzone, Olivier Delézay, Coralie Di Scala, Assou El Battari, Francisco Gonzalez-Scarano, Claude Granier, Nathalie Koch, Xavier Leverve, André Jean, Jean-Marc Sabatier, Louis Sarda, and Catherine Tamalet. We also thank the Fondation Marcel Bleustein-Blanchet pour la Vocation (Paris, France) and the scientific advisors who in- terviewed us, Claude Bernard and François Jacob, for supporting the young scientists that we were before our names appeared in PubMed. It has been a pleasure to work on this book with Kristi Anderson and Natalie Farra from Elsevier/Academic Press. Finally we thank our beloved son Driss, nephews Fahem and Lounis, sister Djamila, brother-in-law Jean-Philippe, and our late parents. Your love is our life.