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I am grateful to have had parents and relatives who instilled in me an interest in asking questions, constantly learning, working hard, and trying to make the world a better place. The deaths of many dear friends and patients because of AIDS stimulated my early work, and the desire to live in a world without AIDS informs my current efforts. Kenneth H. Mayer I dedicate this work to my wife, Christine, who in all ways makes it possible for me to be who I am; and to our marvelous daughter, Katie, and her daughter, Annabel, the newest joy in our lives. Hank F. Pizer v Dedications Dedications