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Dedication This book would not have been possible without the continuous encouragement of our families. We wish to dedicate it to our students, with the hope that progress in diagnosis andmanagement of these diseasesmay result in improved survival and quality of life for the next generations and at the same time that international collaboration in research will happen without barriers. Whatever we have learned comes from our mentors. This book is, therefore, dedicated also to all of them, but most importantly to our patients and their families whose continuous support has guided us over the years. Dedication