Resistência ao SIV em Hospedeiros Naturais

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Introduction
Natural non-human primate hosts of the simian immunodeficiency 
virus (SIV) do not develop AIDS despite carrying viral loads that normally 
lead to pathology and death in non-natural hosts. A large body of data 
that documents a variety of immunological and virological differences 
between SIV-infected natural versus non-natural hosts indicate that the 
clues to disease resistance are mostly host related and have evolved over 
100 if not thousands of years. We now face the daunting task of identifying 
which of these differences (and by what mechanisms) contribute to dis-
ease resistance in the natural hosts and ultimately exploit these findings 
for the design of novel interventions to treat or prevent HIV infection of 
humans.
	Introduction