Bactérias e Doenças Associadas

Vista previa del material en texto

Cocobacilos Gram negativos 
Haemophilus 
H. influenzae, H. ducreyi y H. aegyptius 
Facultativos 
Bordetella 
B. pertussis, B. parapertussis y B. bronchiseptica 
Aerobios estrictos 
Brucella 
B. abortus, B. melitensis y B. suis 
Aerobios estrictos 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Cocobacilos Gram negativos 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Género Brucella 
B. abortus B. suis B. melitensis 
Det A Det M 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Género Brucella 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Brucelosis 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Brucelosis 
Dependiendo de: 
 
1. La virulencia de la cepa y de 
 
2. La defensa del hospedero 
 
Puede cursar en las formas: 
 
• Subaguda (con frecuencia indeterminada) 
 
• Aguda (duración: 3 a 25 semanas) 
 
• Crónica (duración: de 1 año o más) 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Brucelosis 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Brucelosis 
Hemocultivo 
Reacción de 
Huddleson 
IgM + IgG 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Género Haemophilus 
H. influenzae 
H. aegyptius 
Factores X y V 
Factores X y V 
Mucosa faríngea 
Conjuntiva ocular 
H. ducreyi Factor X Mucosa genital 
Especie Requiere Tejido “blanco” 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
H. influenzae 
Sólo aplica en cepas 
no serotipificables 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8Serotipos H. influenzae 
Glucosa 
Ribosa y ribitol 
Galactosa 
Hexosas 
Hexosamina 
a 
b 
c 
d 
e 
CHO capsular Tipo 
Galactosamina f 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Patología H. influenzae 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Factores de patogenicidad 
en H. influenzae 
• Fimbrias 
• Cápsula 
• IgA hidrolasa 
• β-lactamasas 
(algunas cepas) 
• Endotoxina 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
http://biyolojiegitim.yyu.edu.tr/k/Hae/images/Haemophilus influenzae_jpg.jpg
Meningitis por H. influenzae 
 Es la más frecuente; afecta 
desde los 3 meses y hasta 
los 2 años de edad; después, 
de los 2 a los 10 años 
 Presenta los mismos 
síntomas que las meningitis 
causadas por otros μo y virus 
 Se trata oportunamente con 
ampicilina endovenosa y 
refuerzos intramusculares de 
cloranfenicol 
 Px: Vacuna pentavalente; Hib 
conjugada (+ DPaT + VPI) 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
http://images.google.com.mx/imgres?imgurl=http://www.nlm.nih.gov/medlineplus/spanish/ency/images/ency/fullsize/19069.jpg&imgrefurl=http://www.nlm.nih.gov/medlineplus/spanish/ency/esp_imagepages/19069.htm&h=320&w=400&sz=14&hl=es&start=5&tbnid=-gtqJAUWWx_NJM:&tbnh=99&tbnw=124&prev=/images?q=Meningitis&gbv=2&svnum=10&hl=es&sa=G
Dx meningitis por H. influenzae 
1. Frotis al Gram 
LCR Centrifugación SED 
2. Reacciones de quellung 
3. Cultivo en Levinthal, en Fildes 
o en GSc + S. aureus (NAD+) 
Colonias pequeñas 
Auxogramas para factores X y V 
Reacciones de quellung 
SED 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Satelitismo de H. influenzae 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
H. aegyptius 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
H. ducreyi 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Género Bordetella 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
B.pertussis 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Factores de virulencia de 
B. pertussis fase I 
• Pertusígeno (ectotoxina pertussis) 
 Factor promotor de linfocitosis (FPL) 
 Factor de sensibilización a la 
histamina (FSH) 
 Factor activador de los islotes (FAI) 
• Fimbrias 
• Endotoxina • Cápsula 
• Hemaglutinina filamentosa 
• Toxina adenilato ciclasa (TAC) 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Tosferina (3 periodos) 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Tosferina 
Periodo prodrómico o 
catarral 
Periodo paroxístico 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
http://www.sepeap.org/archivos/revisiones/orl/tos.htm
Tosferina: Dx de laboratorio 
Prevención: Vacuna 
pentavalente DPaT + 
Hib + VPI 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8
Gram y cultivo de Bordetella 
̰ 
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+escudo&toggle=1&ei=UTF-8&fr=yfp-t-501&b=21&w=363&h=388&imgurl=depa.pquim.unam.mx/depa_web/downloads/imgs_unam/escudoUNAMb&n3D.jpg&rurl=http://depa.pquim.unam.mx/depa_web/downloads/downloadsold.html&size=81.8kB&name=escudoUNAMb+n3D.jpg&p=unam+escudo&type=jpeg&no=29&tt=53&oid=a1ab1c1b753d4034&ei=UTF-8
http://images.search.yahoo.com/search/images/view?back=http://images.search.yahoo.com/search/images?p=unam+%2B+quimica&ei=UTF-8&fr=yfp-t-501&b=61&w=141&h=138&imgurl=www.unam.mx/val_ind/log.jpg&rurl=http://www.unam.mx/val_ind&size=8.4kB&name=log.jpg&p=unam+++quimica&type=jpeg&no=75&tt=127&oid=a217c4b827ced83a&ei=UTF-8