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Cover illustration: In vitro-derived chimpanzee dendritic cells localize in the lymph node paracortex after subcutaneous injection. Endogenous interdigitating dendritic cells fluoresce green with antibody to MHC class II; injected dendritic cells appear orange due to double-labelling with antibody and a red plasma membrane dye added prior to injection. For further details see Chapter 17. Courtesy of the Center for Biologic Imaging, University of Pittsburgh, USA. Dendritic Cells Second Edition Biology and Clinical Applications Edited by Michael T. Lotze, Discovery Research Biology GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA Angus W. Thomson Departments of Surgery and Molecular Genetics and Biochemistry Thomas E. Starzl Transplantation Institute University of Pittsburgh, PA USA San Diego ● San Francisco ● New York ● Boston London ● Sydney ● Tokyo