<div id="pf1" class="pf w0 h0" data-page-no="1"><div class="pc pc1 w0 h0"><img class="bi x0 y0 w1 h1" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg1.png"><div class="t m0 x1 h2 y1 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h3 y2 ff2 fs1 fc0 sc0 lsa ws0">19<span class="blank"> </span><span class="ff3 fs2 lsb ws1 v1">OFICINA<span class="blank _0"> </span>ESP<span class="blank _1"></span>A<span class="blank"> </span><span class="ls9 v1">\u02dc</span></span></div><div class="t m1 x3 h4 y3 ff3 fs2 fc0 sc0 lsc ws2">NOLA<span class="blank _2"> </span>DE</div><div class="t m1 x4 h4 y4 ff3 fs2 fc0 sc0 lsd ws3">PAT<span class="blank"> </span>E<span class="blank"> </span>N<span class="blank _3"> </span>T<span class="blank"> </span>E<span class="blank"> </span>S<span class="blank _2"> </span>Y<span class="blank _4"> </span>M<span class="blank"> </span>A<span class="blank"> </span>R<span class="blank"> </span>C<span class="blank"> </span>A<span class="blank"> </span>S</div><div class="t m1 x4 h5 y5 ff3 fs2 fc0 sc0 lse ws4">ESP<span class="blank _1"></span>A<span class="blank"> </span><span class="ls9 v1">\u02dc</span></div><div class="t m1 x5 h4 y5 ff3 fs2 fc0 sc0 lsf">NA</div><div class="t m0 x6 h2 y6 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h6 y7 ff2 fs1 fc0 sc0 lsa ws5">11<span class="blank"> </span><span class="ff3 fs2 lsf ws6 v2">N´<span class="blank _5"></span><span class="lsc ws7">umero<span class="blank _4"> </span>de<span class="blank _2"> </span>publicaci<span class="blank"> </span>´<span class="blank _6"></span><span class="ls10 ws8">on:<span class="blank"> </span><span class="ff4 fs3 ls11 ws9">2<span class="blank"> </span>117<span class="blank"> </span>950</span></span></span></span></div><div class="t m0 x6 h2 y8 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h7 y9 ff2 fs1 fc0 sc0 lsa ws5">21<span class="blank"> </span><span class="ff3 fs2 lsf ws6 v2">N´<span class="blank _5"></span><span class="lsc ws7">umero<span class="blank _4"> </span>de<span class="blank _2"> </span>sol<span class="blank"> </span>i<span class="blank"> </span>ci<span class="blank"> </span>t<span class="blank"> </span>ud:<span class="blank _7"> </span><span class="fs4 ls2">9601893</span></span></span></div><div class="t m0 x6 h2 ya ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h7 yb ff2 fs1 fc0 sc0 lsa ws5">51<span class="blank"> </span><span class="ff3 fs2 ls9 wsa v2">Int.<span class="blank _8"> </span>Cl.</span><span class="ff5 fs5 ls0 v3">6</span><span class="ff3 fs2 ls1 v2">:<span class="fs4 ls2 wsb">C07D<span class="blank"> </span>213/74</span></span></div><div class="t m1 x8 h8 yc ff6 fs4 fc0 sc0 ls12 wsc">C07D<span class="blank"> </span>215/10<span class="ff3 ls3">,</span><span class="wsd">C07D<span class="blank"> </span>217/22</span></div><div class="t m1 x8 h8 yd ff6 fs4 fc0 sc0 ls12 wsc">C07D<span class="blank"> </span>401/04<span class="ff3 ls3">,</span><span class="wsd">C07D<span class="blank"> </span>453/02</span></div><div class="t m1 x8 h8 ye ff6 fs4 fc0 sc0 ls12 wsd">//(C07D<span class="blank"> </span>401/04<span class="ff3 ls3">,</span><span class="wse">C07D<span class="blank _8"> </span>213:06</span></div><div class="t m1 x8 h8 yf ff6 fs4 fc0 sc0 ls12 wsc">C07D<span class="blank"> </span>207:04)<span class="blank _3"> </span>,<span class="blank _8"> </span>(<span class="blank _3"> </span>C07D<span class="blank"> </span>401/04</div><div class="t m1 x8 h8 y10 ff6 fs4 fc0 sc0 ls12 wse">C07D<span class="blank _4"> </span>215:<span class="blank"> </span>04<span class="ff3 ls4">,</span>C07D<span class="blank _9"> </span>207:04)</div><div class="t m0 x1 h2 y11 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h7 y12 ff2 fs1 fc0 sc0 lsa wsf">12<span class="blank"> </span><span class="ff3 fs4 ls13 ws10 v2">P<span class="blank _5"></span>A<span class="blank _5"></span>T<span class="blank _a"></span>E<span class="blank _a"></span>N<span class="blank _a"></span>T<span class="blank _a"></span>ED<span class="blank _a"></span>EI<span class="blank _a"></span>N<span class="blank _b"></span>V<span class="blank _b"></span>E<span class="blank _a"></span>N<span class="blank _a"></span>C<span class="blank _a"></span>I<span class="blank _a"></span>O<span class="blank _a"></span>N<span class="blank"> </span>B<span class="blank _a"></span>1</span></div><div class="t m0 x1 h2 y13 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y14 ff2 fs1 fc0 sc0 lsa ws5">22<span class="blank"> </span><span class="ff3 fs2 lsc ws7 v2">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>presentaci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws11">on:<span class="blank"> </span><span class="ff7">02.08.96</span></span></span></div><div class="t m0 x6 h2 y13 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h9 y14 ff2 fs1 fc0 sc0 lsa ws5">73<span class="blank"> </span><span class="ff3 fs2 ls14 ws12 v2">Titula<span class="blank _c"></span>r/es:<span class="blank"> </span><span class="ff7 ls15 ws13">Uni<span class="blank"> </span>v<span class="blank"> </span>ers<span class="blank _3"> </span>ida<span class="blank"> </span>d<span class="blank _2"> </span>de<span class="blank _4"> </span>Granada</span></span></div><div class="t m1 x9 h4 y15 ff7 fs2 fc0 sc0 ls16 ws14">C/<span class="blank _2"> </span>Sa<span class="blank"> </span>nt<span class="blank"> </span>a<span class="blank _4"> </span>Luc<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls17 ws15">\u0131<span class="blank _e"></span>a<span class="blank _a"></span>,2<span class="blank _e"></span>,2</span></div><div class="t m1 xa h4 y16 ff7 fs2 fc0 sc0 ls9">a</div><div class="t m1 xa ha y17 ff7 fs2 fc0 sc0 ls5">¯<span class="lse ws16 v4">Planta</span></div><div class="t m1 x9 h4 y18 ff7 fs2 fc0 sc0 ls18 ws17">18071<span class="blank"> </span>Gr<span class="blank _c"></span>anada,<span class="blank _2"> </span>ES</div><div class="t m0 x1 h2 y19 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y1a ff2 fs1 fc0 sc0 lsa ws5">43<span class="blank"> </span><span class="ff3 fs2 lsc ws7 v2">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>publi<span class="blank"> </span>ca<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls19 ws18">on<span class="blank _4"> </span>de<span class="blank"> </span>la<span class="blank"> </span>solicitud<span class="blank _c"></span>:<span class="blank _9"> </span><span class="ff7 lse">16.08.98</span></span></span></div><div class="t m1 xb h4 y1b ff3 fs2 fc0 sc0 lsc ws7">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>conces<span class="blank"> </span>i<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws11">on:<span class="blank"> </span><span class="ff7">15.06.99</span></span></div><div class="t m0 x6 h2 y1c ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h9 y1d ff2 fs1 fc0 sc0 lsa ws5">72<span class="blank"> </span><span class="ff3 fs2 lsc ws19 v2">Inv<span class="blank"> </span>ent<span class="blank"> </span>or/<span class="blank"> </span>es<span class="blank _3"> </span>:<span class="blank _9"> </span><span class="ff7 ls16 ws1a">E<span class="blank"> </span>s<span class="blank _3"> </span>pinos<span class="blank _3"> </span>a<span class="blank _2"> </span>Ub<span class="blank"> </span>eda<span class="blank"> </span>,<span class="blank _4"> </span>Anto<span class="blank"> </span>ni<span class="blank"> </span>o<span class="blank"> </span>;</span></span></div><div class="t m1 x9 h4 y1e ff7 fs2 fc0 sc0 lse ws1b">Lacal<span class="blank"> </span>S<span class="blank _c"></span>anjuan<span class="blank _c"></span>,<span class="blank _4"> </span>Juan<span class="blank"> </span>Ca<span class="blank _c"></span>rlos;</div><div class="t m1 x9 h4 y1f ff7 fs2 fc0 sc0 ls8 ws1c">Gallo<span class="blank _f"> </span>Mezo,<span class="blank _f"> </span>Miguel<span class="blank"> </span>A<span class="blank _c"></span>nge<span class="blank _c"></span>l<span class="blank"> </span>y</div><div class="t m1 x9 h4 y20 ff7 fs2 fc0 sc0 ls1a ws14">Camp<span class="blank"> </span>os<span class="blank _4"> </span>Ros<span class="blank"> </span>a,<span class="blank _2"> </span>J<span class="blank"> </span>o<span class="blank"> </span>aqu<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1b ws1d">\u0131n<span class="blank"> </span>Ma<span class="blank _c"></span>r<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls1c">\u0131a</span></span></div><div class="t m1 xb h4 y21 ff3 fs2 fc0 sc0 lsc ws7">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>mo<span class="blank _3"> </span>di<span class="blank"> </span>\ufb01ca<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span>o<span class="blank"> </span>n<span class="blank _4"> </span>de<span class="blank _2"> </span>las<span class="blank _2"> </span>r<span class="blank"> </span>ei<span class="blank"> </span>vi<span class="blank"> </span>ndi<span class="blank"> </span>ca<span class="blank"> </span>ci<span class="blank"> </span>o<span class="blank"> </span>nes<span class="blank"> </span>:</div><div class="t m1 xc h4 y22 ff7 fs2 fc0 sc0 lse">08.11.98</div><div class="t m0 x1 h2 y23 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y24 ff2 fs1 fc0 sc0 lsa ws5">45<span class="blank"> </span><span class="ff3 fs2 lsc ws7 v2">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>anunci<span class="blank"> </span>o<span class="blank _4"> </span>de<span class="blank _2"> </span>la<span class="blank _2"> </span>co<span class="blank"> </span>nces<span class="blank"> </span>i<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws1e">on:<span class="blank"> </span><span class="ff7">16.09.99</span></span></span></div><div class="t m0 x1 h2 y25 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y26 ff2 fs1 fc0 sc0 lsa ws5">45<span class="blank"> </span><span class="ff3 fs2 lsc ws7 v2">Fecha<span class="blank _2"> </span>de<span class="blank _2"> </span>publi<span class="blank"> </span>ca<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span>o<span class="blank"> </span>n<span class="blank _4"> </span>del<span class="blank _4"> </span>fo<span class="blank"> </span>l<span class="blank"> </span>l<span class="blank"> </span>eto<span class="blank _2"> </span>de<span class="blank _2"> </span>pat<span class="blank"> </span>ent<span class="blank"> </span>e:</span></div><div class="t m1 xc h4 y27 ff7 fs2 fc0 sc0 lse">16.09.99</div><div class="t m0 x6 h2 y25 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x7 h9 y26 ff2 fs1 fc0 sc0 lsa ws5">74<span class="blank"> </span><span class="ff3 fs2 lsc ws19 v2">Ag<span class="blank"> </span>ent<span class="blank"> </span>e:<span class="blank _7"> </span><span class="ff7 ls16 ws1a">No<span class="blank _4"> </span>cons<span class="blank"> </span>t<span class="blank"> </span>a</span></span></div><div class="t m0 x1 h2 y28 ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y29 ff2 fs1 fc0 sc0 lsa ws5">54<span class="blank"> </span><span class="ff3 fs2 ls1d ws1f v2">T´<span class="blank _10"></span><span class="ls18 ws20">\u0131tulo:<span class="blank"> </span><span class="ff7 ls16 ws21">Nuevos<span class="blank _7"> </span>compues<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _9"> </span>que<span class="blank _9"> </span>bl<span class="blank"> </span>o<span class="blank _3"> </span>quean<span class="blank _7"> </span>l<span class="blank"> </span>a<span class="blank _9"> </span>bios<span class="blank _1"></span>´<span class="blank _b"></span>\u0131nt<span class="blank"> </span>es<span class="blank"> </span>i<span class="blank"> </span>s<span class="blank _9"> </span>de<span class="blank _9"> </span>fosf<span class="blank"> </span>oril<span class="blank"> </span>co<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _8"> </span>y<span class="blank _9"> </span>s<span class="blank"> </span>u<span class="blank _9"> </span>us<span class="blank"> </span>o<span class="blank _9"> </span>como<span class="blank _7"> </span>segundo</span></span></span></div><div class="t m1 xd h4 y2a ff7 fs2 fc0 sc0 ls1e ws22">men<span class="blank _c"></span>sajer<span class="blank _c"></span>o<span class="blank"> </span>en<span class="blank _2"> </span>pr<span class="blank _c"></span>olifer<span class="blank _c"></span>aci´<span class="blank _11"></span>on<span class="blank"> </span>ce<span class="blank _c"></span>lula<span class="blank _c"></span>r.</div><div class="t m0 x1 h2 y2b ff1 fs0 fc0 sc0 ls9"><span class="fc1 sc0">k</span></div><div class="t m1 x2 h9 y2c ff2 fs1 fc0 sc0 lsa ws5">57<span class="blank"> </span><span class="ff3 fs2 lsc ws2 v2">Res<span class="blank"> </span>um<span class="blank"> </span>en:</span></div><div class="t m1 x2 h4 y2d ff3 fs2 fc0 sc0 lsc ws7">La<span class="blank _2"> </span>i<span class="blank"> </span>nv<span class="blank"> </span>enci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws23">on<span class="blank"> </span>est´<span class="blank _5"></span><span class="lsc ws7">a<span class="blank _2"> </span>relaci<span class="blank"> </span>o<span class="blank _3"> </span>nada<span class="blank _4"> </span>co<span class="blank"> </span>n<span class="blank _4"> </span>el<span class="blank _2"> </span>dis<span class="blank"> </span>e\u02dc<span class="blank _5"></span>no<span class="blank"> </span>,<span class="blank _8"> </span>s<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls6 ws24">\u0131nte<span class="blank _c"></span>sis</span></span></span></div><div class="t m1 x2 h4 y2e ff3 fs2 fc0 sc0 ls1f ws25">y<span class="blank"> </span>activid<span class="blank _c"></span>ad<span class="blank"> </span>biol´<span class="blank _5"></span><span class="lsc ws26">og<span class="blank"> </span>ica<span class="blank _2"> </span>de<span class="blank _4"> </span>do<span class="blank"> </span>s<span class="blank _4"> </span>nuevas<span class="blank _4"> </span>es<span class="blank"> </span>tr<span class="blank"> </span>a<span class="blank"> </span>teg<span class="blank"> </span>i<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _4"> </span>para</span></div><div class="t m1 x2 h4 y2f ff3 fs2 fc0 sc0 lsc ws7">ab<span class="blank"> </span>ordar<span class="blank _7"> </span>el<span class="blank _9"> </span>desarr<span class="blank"> </span>o<span class="blank"> </span>l<span class="blank"> </span>l<span class="blank"> </span>o<span class="blank _9"> </span>de<span class="blank _9"> </span>co<span class="blank _3"> </span>mpuest<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _7"> </span>que<span class="blank _7"> </span>presenten</div><div class="t m1 x2 h4 y30 ff3 fs2 fc0 sc0 lsc ws7">acti<span class="blank"> </span>v<span class="blank"> </span>i<span class="blank"> </span>da<span class="blank"> </span>des<span class="blank _4"> </span>select<span class="blank"> </span>i<span class="blank"> </span>v<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>co<span class="blank"> </span>m<span class="blank"> </span>o<span class="blank _2"> </span>anti<span class="blank"> </span>ca<span class="blank"> </span>ncero<span class="blank"> </span>s<span class="blank"> </span>o<span class="blank _3"> </span>s,<span class="blank _2"> </span>a<span class="blank"> </span>nt<span class="blank"> </span>i<span class="blank"> </span>vi<span class="blank"> </span>r<span class="blank"> </span>a<span class="blank"> </span>-</div><div class="t m1 x2 h4 y31 ff3 fs2 fc0 sc0 ls1f ws27">les,<span class="blank"> </span>antipa<span class="blank _c"></span>rasita<span class="blank _c"></span>rios<span class="blank"> </span>y<span class="blank"> </span>an<span class="blank _c"></span>tif´<span class="blank _5"></span><span class="lsc ws7">ungi<span class="blank"> </span>co<span class="blank"> </span>s<span class="blank"> </span>.</span></div><div class="t m1 x2 h4 y32 ff3 fs2 fc0 sc0 ls8 ws28">Aqu<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls6 ws29">\u0131<span class="blank"> </span>se<span class="blank"> </span>describe<span class="blank _4"> </span>la<span class="blank"> </span>utilizaci´<span class="blank _5"></span><span class="lsc ws7">on<span class="blank _4"> </span>de<span class="blank _4"> </span>la<span class="blank _2"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls18 ws2a">on<span class="blank _4"> </span>de<span class="blank"> </span>la</span></span></span></div><div class="t m1 x2 h4 y33 ff3 fs2 fc0 sc0 lsc ws7">bio<span class="blank"> </span>s<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls1f ws2b">\u0131nte<span class="blank _c"></span>sis<span class="blank"> </span>de<span class="blank"> </span>fosfor<span class="blank _c"></span>ilcolina<span class="blank _0"> </span>y<span class="blank _0"> </span>de<span class="blank"> </span>su<span class="blank"> </span>ac<span class="blank _c"></span>ci´<span class="blank _5"></span><span class="ls18 ws2c">on<span class="blank"> </span>mitog<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsc ws7">enica</span></span></span></div><div class="t m1 x2 h4 y34 ff3 fs2 fc0 sc0 lsc ws19">com<span class="blank"> </span>o<span class="blank _7"> </span>una<span class="blank _7"> </span>nueva<span class="blank _7"> </span>est<span class="blank"> </span>ra<span class="blank"> </span>t<span class="blank"> </span>eg<span class="blank _3"> </span>ia<span class="blank _9"> </span>para<span class="blank _7"> </span>el<span class="blank _9"> </span>t<span class="blank"> </span>ra<span class="blank _3"> </span>tam<span class="blank"> </span>i<span class="blank"> </span>ent<span class="blank"> </span>o<span class="blank _7"> </span>de</div><div class="t m1 x2 h4 y35 ff3 fs2 fc0 sc0 lsc ws2">tumores<span class="blank _2"> </span>y<span class="blank _f"> </span>de<span class="blank _12"> </span>enfer<span class="blank"> </span>m<span class="blank"> </span>eda<span class="blank"> </span>des<span class="blank _4"> </span>parasi<span class="blank"> </span>t<span class="blank"> </span>aria<span class="blank"> </span>s<span class="blank _f"> </span>o<span class="blank _f"> </span>p<span class="blank _c"></span>ro<span class="blank _3"> </span>ducida<span class="blank"> </span>s</div><div class="t m1 x2 h4 y36 ff3 fs2 fc0 sc0 lsc ws2">por<span class="blank _4"> </span>virus<span class="blank _2"> </span>y<span class="blank _2"> </span>hong<span class="blank _3"> </span>os<span class="blank _2"> </span>en<span class="blank _2"> </span>a<span class="blank"> </span>ni<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _2"> </span>y<span class="blank _2"> </span>en<span class="blank _2"> </span>hum<span class="blank"> </span>a<span class="blank"> </span>no<span class="blank"> </span>s<span class="blank"> </span>.</div><div class="t m1 x2 h4 y37 ff3 fs2 fc0 sc0 lsc ws7">Los<span class="blank _9"> </span>co<span class="blank _3"> </span>mpuest<span class="blank"> </span>o<span class="blank _3"> </span>s<span class="blank _7"> </span>que<span class="blank _9"> </span>s<span class="blank"> </span>e<span class="blank _9"> </span>descr<span class="blank"> </span>i<span class="blank"> </span>b<span class="blank _3"> </span>en<span class="blank _13"> </span>per<span class="blank"> </span>t<span class="blank"> </span>enecen<span class="blank _14"> </span>a<span class="blank _8"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s</div><div class="t m1 x2 h4 y38 ff3 fs2 fc0 sc0 ls6 ws2d">familias<span class="blank"> </span>estruc<span class="blank _c"></span>turale<span class="blank _c"></span>s<span class="blank _4"> </span>qu<span class="blank _c"></span>e<span class="blank _4"> </span>han<span class="blank"> </span>de<span class="blank _c"></span>mostrado<span class="blank"> </span>actividad</div><div class="t m1 x2 h4 y39 ff3 fs2 fc0 sc0 ls6 ws2e">antitumo<span class="blank _c"></span>ral,<span class="blank"> </span>antipar<span class="blank _c"></span>asitaria<span class="blank"> </span>y<span class="blank"> </span>an<span class="blank _c"></span>tif´<span class="blank _5"></span><span class="lsc ws2">ungi<span class="blank"> </span>ca<span class="blank"> </span>,<span class="blank _2"> </span>que<span class="blank _f"> </span>deben</span></div><div class="t m1 x2 h4 y3a ff3 fs2 fc0 sc0 lsc ws26">ser<span class="blank _8"> </span>cons<span class="blank"> </span>i<span class="blank"> </span>dera<span class="blank"> </span>do<span class="blank"> </span>s<span class="blank _9"> </span>y<span class="blank _8"> </span>p<span class="blank _c"></span>ro<span class="blank"> </span>t<span class="blank"> </span>eg<span class="blank"> </span>ido<span class="blank"> </span>s<span class="blank _8"> </span>com<span class="blank"> </span>o<span class="blank _8"> </span>co<span class="blank"> </span>m<span class="blank"> </span>pues<span class="blank"> </span>to<span class="blank"> </span>s<span class="blank _8"> </span>di<span class="blank"> </span>-</div><div class="t m1 x2 h4 y3b ff3 fs2 fc0 sc0 ls6 ws2d">rec<span class="blank _c"></span>tamente<span class="blank"> </span>utilizados<span class="blank"> </span>en<span class="blank"> </span>el<span class="blank"> </span>tratamie<span class="blank _c"></span>nto<span class="blank"> </span>de<span class="blank"> </span>estas<span class="blank"> </span>e<span class="blank _c"></span>n-</div><div class="t m1 x2 h4 y3c ff3 fs2 fc0 sc0 lsc ws2">fer<span class="blank"> </span>m<span class="blank"> </span>eda<span class="blank"> </span>des<span class="blank _4"> </span>en<span class="blank _4"> </span>anima<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _2"> </span>y<span class="blank _2"> </span>huma<span class="blank"> </span>no<span class="blank _3"> </span>s.</div><div class="t m1 x2 h4 y3d ff3 fs2 fc0 sc0 lsc ws7">Fi<span class="blank"> </span>na<span class="blank"> </span>l<span class="blank"> </span>m<span class="blank"> </span>ent<span class="blank"> </span>e,<span class="blank _15"> </span>se<span class="blank _16"> </span>descri<span class="blank"> </span>b<span class="blank _3"> </span>en<span class="blank _17"> </span>y<span class="blank _14"> </span>prot<span class="blank"> </span>eg<span class="blank"> </span>en<span class="blank _17"> </span>tam<span class="blank"> </span>bi´<span class="blank _6"></span>en<span class="blank _16"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s</div><div class="t m1 x2 h4 y3e ff3 fs2 fc0 sc0 ls20 ws2">m´<span class="blank _6"></span><span class="ls18 ws19">etodos<span class="blank _4"> </span>sint<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsc ws7">et<span class="blank"> </span>i<span class="blank"> </span>co<span class="blank"> </span>s<span class="blank _8"> </span>de<span class="blank _9"> </span>to<span class="blank _3"> </span>dos<span class="blank _4"> </span>l<span class="blank"> </span>o<span class="blank _3"> </span>s<span class="blank _4"> </span>com<span class="blank"> </span>pues<span class="blank"> </span>t<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _9"> </span>descri<span class="blank"> </span>-</span></span></div><div class="t m1 x2 h4 y3f ff3 fs2 fc0 sc0 ls6 ws24">tos.</div><div class="t m1 x2 h8 y40 ff3 fs4 fc0 sc0 ls21 ws2f">Aviso:<span class="blank"> </span><span class="fs2 lsc ws7">Se<span class="blank _2"> </span>puede<span class="blank _2"> </span>rea<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>z<span class="blank"> </span>ar<span class="blank _2"> </span>co<span class="blank _3"> </span>nsult<span class="blank"> </span>a<span class="blank _2"> </span>previs<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank _4"> </span>por<span class="blank _2"> </span>el<span class="blank _2"> </span>art<span class="ff8 fs5 ls7 v4">\u25e6</span><span class="ls8 ws30">37.3.8<span class="blank"> </span>LP<span class="blank _1"></span>.</span></span></div><div class="t m1 xd hb y41 ff9 fs6 fc0 sc0 ls22 ws31">V<span class="blank _e"></span>e<span class="blank _18"></span>n<span class="blank _19"></span>t<span class="blank _18"></span>ad<span class="blank _19"></span>ef<span class="blank _18"></span>a<span class="blank _18"></span>s<span class="blank _18"></span>c<span class="blank _a"></span>´<span class="blank _1a"></span><span class="ls23 ws32">\u0131culo<span class="blank _c"></span>s:<span class="blank _4"> </span>O\ufb01cina<span class="blank _0"> </span>Espa\u02dc<span class="blank _b"></span><span class="ls24 ws33">nola<span class="blank _0"> </span>de<span class="blank _f"> </span>Patentes<span class="blank _0"> </span>y<span class="blank _f"> </span>Marcas.<span class="blank _4"> </span>C/Panam´<span class="blank _b"></span><span class="ls25 ws32">a,<span class="blank _f"> </span>1<span class="blank _0"> </span>\u2013<span class="blank _f"> </span>28036<span class="blank _f"> </span>Madri<span class="blank"> </span>d</span></span></span></div><div class="t m2 xe hc y42 ffa fs7 fc0 sc0 ls9 ws34">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank"> </span>950<span class="blank"> </span>B1</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf2" class="pf w0 h0" data-page-no="2"><div class="pc pc2 w0 h0"><img class="bi xf y43 w2 hd" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg2.png"><div class="t m1 x10 he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x0 hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x11 hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x11 hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x11 hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x11 hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x11 hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x11 hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x11 hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x11 hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x11 hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x11 hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x11 hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x12 h4 y51 ff4 fs2 fc0 sc0 ls1c ws37">DESC<span class="blank _c"></span>RIPC<span class="blank _c"></span>ION</div><div class="t m1 x13 h4 y52 ffb fs2 fc0 sc0 lsc ws38">Nuevos<span class="blank _2"> </span>co<span class="blank"> </span>m<span class="blank _3"> </span>puesto<span class="blank _3"> </span>s<span class="blank _2"> </span>que<span class="blank _2"> </span>blo<span class="blank _3"> </span>q<span class="blank"> </span>u<span class="blank"> </span>ea<span class="blank _3"> </span>n<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>bi<span class="blank"> </span>o<span class="blank _3"> </span>s<span class="blank _d"></span>´<span class="blank _e"></span><span class="ls2d ws39">\u0131nte<span class="blank _c"></span>sis<span class="blank _2"> </span>de<span class="blank _f"> </span>fo<span class="blank"> </span>sfori<span class="blank"> </span>l<span class="blank"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _f"> </span>y<span class="blank _f"> </span>su<span class="blank _f"> </span>uso<span class="blank _2"> </span>como<span class="blank _f"> </span>segundo<span class="blank _2"> </span>mensa<span class="blank _3"> </span>jero<span class="blank _2"> </span>en</span></div><div class="t m1 x14 h4 y53 ffb fs2 fc0 sc0 ls1c ws3a">prolife<span class="blank _c"></span>r<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls10 ws3b">on<span class="blank"> </span>ce<span class="blank _c"></span>lular.</span></div><div class="t m1 x14 h4 y54 ffb fs2 fc0 sc0 ls1c ws3c">2.-<span class="blank"> </span><span class="ff4 ls2e ws3d">Sec<span class="blank _c"></span>tor<span class="blank _f"> </span>de<span class="blank _4"> </span>la<span class="blank"> </span>t<span class="blank _c"></span>´<span class="blank _11"></span>ec<span class="blank _c"></span>nic<span class="blank _c"></span>a<span class="blank"> </span>(Ca<span class="blank _c"></span>mpo<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank"> </span>i<span class="blank _c"></span>nv<span class="blank _c"></span>e<span class="blank _c"></span>nci<span class="blank _c"></span>´<span class="blank _1a"></span><span class="ls19 ws3e">on<span class="blank _3"> </span>)</span></span></div><div class="t m1 x13 h4 y55 ffb fs2 fc0 sc0 lsc ws38">La<span class="blank _12"> </span>p<span class="blank"> </span>r<span class="blank"> </span>esente<span class="blank _f"> </span>i<span class="blank _3"> </span>nv<span class="blank _c"></span>enci<span class="blank"> </span>´<span class="blank _6"></span><span class="ls10 ws3f">on<span class="blank"> </span>es<span class="blank _c"></span>t´<span class="blank _1b"></span><span class="ls14 ws40">a<span class="blank _12"> </span>relacio<span class="blank"> </span>nada<span class="blank _12"> </span>con<span class="blank _12"> </span>el<span class="blank _12"> </span>dise<span class="blank"> </span>\u02dc<span class="blank _1b"></span>no<span class="blank"> </span>,<span class="blank _f"> </span>s<span class="blank _d"></span>´<span class="blank _e"></span><span class="ls1c ws41">\u0131n<span class="blank _c"></span>t<span class="blank _c"></span>es<span class="blank _c"></span>is<span class="blank _12"> </span>y<span class="blank _0"> </span>activid<span class="blank _c"></span>ad<span class="blank"> </span>biol´<span class="blank _1b"></span><span class="ls2d ws39">og<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank _0"> </span>de<span class="blank _12"> </span>dos<span class="blank _0"> </span>nuev<span class="blank _c"></span>as<span class="blank _12"> </span>estra-</span></span></span></span></div><div class="t m1 x14 h4 y56 ffb fs2 fc0 sc0 ls1e ws42">te<span class="blank _c"></span>gias<span class="blank"> </span>par<span class="blank _c"></span>a<span class="blank"> </span>abordar<span class="blank"> </span>el<span class="blank"> </span>de<span class="blank _c"></span>sarr<span class="blank _c"></span>ollo<span class="blank"> </span>de<span class="blank"> </span>comp<span class="blank _c"></span>ues<span class="blank _c"></span>tos<span class="blank"> </span>que<span class="blank"> </span>pr<span class="blank _c"></span>es<span class="blank _c"></span>en<span class="blank _c"></span>te<span class="blank _c"></span>n<span class="blank _f"> </span>actividad<span class="blank _c"></span>es<span class="blank _0"> </span>se<span class="blank _c"></span>lec<span class="blank _c"></span>tiv<span class="blank _1"></span>as<span class="blank _f"> </span>c<span class="blank _c"></span>omo<span class="blank"> </span>an<span class="blank _c"></span>tican<span class="blank _c"></span>ce<span class="blank _c"></span>ros<span class="blank _c"></span>os,</div><div class="t m1 x14 h4 y57 ffb fs2 fc0 sc0 ls2f ws16">antiviral<span class="blank"> </span>es,<span class="blank _f"> </span>antiparasi<span class="blank"> </span>tari<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>y<span class="blank _2"> </span>antif<span class="blank"> </span>´<span class="blank _1b"></span><span class="ls14 ws40">ung<span class="blank"> </span>i<span class="blank"> </span>cos.</span></div><div class="t m1 x13 h4 y58 ffb fs2 fc0 sc0 ls30 ws43">En<span class="blank _2"> </span>f<span class="blank"> </span>o<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank _2"> </span>resum<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>,<span class="blank _4"> </span>aqu<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls1b ws44">\u0131<span class="blank _2"> </span>se<span class="blank _2"> </span>de<span class="blank _c"></span>sc<span class="blank _c"></span>ribe<span class="blank _4"> </span>la<span class="blank _f"> </span>utiliz<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls14 ws40">on<span class="blank _2"> </span>de<span class="blank _2"> </span>la<span class="blank _2"> </span>inhi<span class="blank"> </span>bi<span class="blank"> </span>ci´<span class="blank _5"></span>on<span class="blank _f"> </span>de<span class="blank _4"> </span>la<span class="blank _2"> </span>bios<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls1c ws45">\u0131nt<span class="blank _c"></span>es<span class="blank _c"></span>is<span class="blank _2"> </span>de<span class="blank"> </span>fosfor<span class="blank _c"></span>ilcolina,</span></span></span></div><div class="t m1 x14 h4 y59 ffb fs2 fc0 sc0 ls14 ws40">mediante<span class="blank _2"> </span>blo<span class="blank"> </span>q<span class="blank"> </span>ueo<span class="blank _2"> </span>selec<span class="blank _c"></span>tivo<span class="blank _4"> </span>de<span class="blank _2"> </span>la<span class="blank _2"> </span>enz<span class="blank _c"></span>im<span class="blank"> </span>a<span class="blank _4"> </span>colina<span class="blank _2"> </span>quinasa,<span class="blank _4"> </span>en<span class="blank _2"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls31 ws46">el<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>t<span class="blank"> </span>um<span class="blank _3"> </span>ora<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _2"> </span>o<span class="blank _4"> </span>en<span class="blank _4"> </span>c´<span class="blank _5"></span><span class="ls10 ws47">elulas<span class="blank"> </span>afe<span class="blank _c"></span>ctad<span class="blank _c"></span>as<span class="blank"> </span>por</span></span></div><div class="t m1 x14 h4 y5a ffb fs2 fc0 sc0 lsc ws48">in<span class="blank"> </span>f<span class="blank"> </span>ecci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls32 ws49">on<span class="blank _4"> </span>parasi<span class="blank"> </span>ta<span class="blank"> </span>ri<span class="blank"> </span>a<span class="blank"> </span>,<span class="blank _2"> </span>como<span class="blank _4"> </span>una<span class="blank _2"> </span>nuev<span class="blank _c"></span>a<span class="blank _2"> </span>estrategia<span class="blank _4"> </span>p<span class="blank"> </span>a<span class="blank"> </span>ra<span class="blank _4"> </span>el<span class="blank _2"> </span>trata<span class="blank"> </span>m<span class="blank _3"> </span>iento<span class="blank _2"> </span>de<span class="blank _2"> </span>tumores<span class="blank _4"> </span>y<span class="blank _2"> </span>de<span class="blank _2"> </span>enf<span class="blank"> </span>erm<span class="blank"> </span>eda<span class="blank"> </span>des<span class="blank _8"> </span>pa-</span></div><div class="t m1 x14 h4 y5b ffb fs2 fc0 sc0 ls1e ws4a">ras<span class="blank _c"></span>itarias<span class="blank"> </span>o<span class="blank"> </span>produc<span class="blank _c"></span>idas<span class="blank"> </span>por<span class="blank _f"> </span>virus<span class="blank"> </span>y<span class="blank"> </span>hongos<span class="blank"> </span>en<span class="blank"> </span>animales<span class="blank _0"> </span>y<span class="blank"> </span>en<span class="blank _f"> </span>humanos<span class="blank _c"></span>.<span class="blank _4"> </span>T<span class="blank _1c"></span>amb<span class="blank _c"></span>i´<span class="blank _5"></span><span class="ls1b ws44">e<span class="blank _c"></span>n<span class="blank _12"> </span>se<span class="blank _f"> </span>de<span class="blank _c"></span>sc<span class="blank _c"></span>ribe<span class="blank _2"> </span>la<span class="blank _12"> </span>utilizac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls10">on</span></span></div><div class="t m1 x14 h4 y5c ffb fs2 fc0 sc0 ls2d ws4b">de<span class="blank _f"> </span>derivados<span class="blank _f"> </span>u<span class="blank _2"> </span>hom´<span class="blank _5"></span><span class="ls8 ws4c">ologos<span class="blank _12"> </span>de<span class="blank _2"> </span>fos<span class="blank _c"></span>forilc<span class="blank _c"></span>olina,<span class="blank _0"> </span>el<span class="blank _2"> </span>pr<span class="blank _c"></span>oducto<span class="blank"> </span>dire<span class="blank _1c"></span>cto<span class="blank _2"> </span>que<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank _2"> </span>origin<span class="blank _c"></span>a<span class="blank"> </span>por<span class="blank _2"> </span>la<span class="blank"> </span>ac<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="lsc ws38">on<span class="blank _2"> </span>de<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>en<span class="blank"> </span>zi<span class="blank _3"> </span>ma</span></span></div><div class="t m1 x14 h4 y5d ffb fs2 fc0 sc0 ls2d ws39">colin<span class="blank"> </span>a<span class="blank _4"> </span>qui<span class="blank"> </span>nasa<span class="blank _4"> </span>cito<span class="blank"> </span>s´<span class="blank _5"></span><span class="ls1c ws4d">olica,<span class="blank _4"> </span>que<span class="blank _2"> </span>blo<span class="blank"> </span>que<span class="blank _c"></span>an<span class="blank _4"> </span>la<span class="blank _4"> </span>ac<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="ls8 ws4e">on<span class="blank"> </span>mitog<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls1c ws4f">enic<span class="blank _1c"></span>a<span class="blank _4"> </span>de<span class="blank _4"> </span>la<span class="blank _4"> </span>fosfor<span class="blank _c"></span>ilcolina<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _8"> </span>c´<span class="blank _1b"></span><span class="ls31 ws46">el<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>tum<span class="blank _3"> </span>ora<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _8"> </span>e</span></span></span></span></div><div class="t m1 x14 h4 y5e ffb fs2 fc0 sc0 ls8 ws50">infe<span class="blank _c"></span>ctad<span class="blank _c"></span>as<span class="blank _2"> </span>p<span class="blank"> </span>or<span class="blank _4"> </span>vir<span class="blank _c"></span>us<span class="blank _2"> </span>y<span class="blank _2"> </span>par´<span class="blank _1b"></span><span class="ls1e ws22">asit<span class="blank _c"></span>os.<span class="blank _14"> </span>Los<span class="blank"> </span>dos<span class="blank"> </span>c<span class="blank _c"></span>ampos<span class="blank"> </span>de<span class="blank"> </span>inv<span class="blank _1c"></span>enc<span class="blank _c"></span>i´<span class="blank _5"></span><span class="lse ws51">on<span class="blank"> </span>aqu<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls31 ws46">\u0131<span class="blank _4"> </span>descri<span class="blank"> </span>to<span class="blank"> </span>s<span class="blank _8"> </span>con<span class="blank"> </span>sti<span class="blank _3"> </span>tuyen<span class="blank _4"> </span>nuevas<span class="blank _2"> </span>est<span class="blank"> </span>ra<span class="blank"> </span>-</span></span></span></div><div class="t m1 x14 h4 y5f ffb fs2 fc0 sc0 ls8 ws52">te<span class="blank _c"></span>gias<span class="blank"> </span>para<span class="blank _2"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>tratamie<span class="blank _c"></span>n<span class="blank _c"></span>to<span class="blank"> </span>de<span class="blank"> </span>tu<span class="blank _c"></span>mores<span class="blank"> </span>y<span class="blank"> </span>e<span class="blank _c"></span>nfer<span class="blank _1c"></span>medade<span class="blank _c"></span>s<span class="blank _4"> </span>parasit<span class="blank _c"></span>arias,<span class="blank _2"> </span>vir<span class="blank _c"></span>ales<span class="blank"> </span>y<span class="blank"> </span>f´<span class="blank _1b"></span>ungic<span class="blank _c"></span>as<span class="blank"> </span>en<span class="blank"> </span>animale<span class="blank _1c"></span>s<span class="blank"> </span>y<span class="blank"> </span>en</div><div class="t m1 x14 h4 y60 ffb fs2 fc0 sc0 ls33 ws53">hum<span class="blank _3"> </span>a<span class="blank _3"> </span>n<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank"> </span>.</div><div class="t m1 x13 h4 y61 ffb fs2 fc0 sc0 ls1b ws1c">As<span class="blank _c"></span>imismo,<span class="blank"> </span>aq<span class="blank _c"></span>u<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls34 ws54">\u0131t<span class="blank _a"></span>a<span class="blank _b"></span>m<span class="blank _a"></span>b<span class="blank _b"></span>i<span class="blank _b"></span>´<span class="blank _1d"></span><span class="ls8 ws50">en<span class="blank _2"> </span>se<span class="blank _4"> </span>des<span class="blank _1c"></span>criben<span class="blank _8"> </span>compue<span class="blank _1c"></span>stos<span class="blank _4"> </span>pert<span class="blank _c"></span>en<span class="blank _c"></span>ec<span class="blank _c"></span>ien<span class="blank _1c"></span>tes<span class="blank _9"> </span>a<span class="blank _4"> </span>v<span class="blank _1c"></span>arias<span class="blank _2"> </span>familias<span class="blank _2"> </span>es<span class="blank _1c"></span>truc<span class="blank _c"></span>tur<span class="blank _c"></span>ales<span class="blank _8"> </span>que</span></span></div><div class="t m1 x14 h4 y62 ffb fs2 fc0 sc0 ls1e ws55">han<span class="blank"> </span>de<span class="blank _c"></span>mostr<span class="blank _1c"></span>ado<span class="blank _2"> </span>actividad<span class="blank"> </span>an<span class="blank _1c"></span>titumoral,<span class="blank _12"> </span>an<span class="blank _c"></span>tipar<span class="blank _c"></span>asitar<span class="blank _c"></span>ia<span class="blank"> </span>y<span class="blank"> </span>antif´<span class="blank _1b"></span><span class="ls2d ws39">ungica,<span class="blank _2"> </span>que<span class="blank _2"> </span>de<span class="blank _c"></span>b<span class="blank"> </span>en<span class="blank _4"> </span>ser<span class="blank _2"> </span>considerados<span class="blank _4"> </span>y<span class="blank _f"> </span>pro<span class="blank"> </span>-</span></div><div class="t m1 x14 h4 y63 ffb fs2 fc0 sc0 ls8 ws56">te<span class="blank _c"></span>gidos<span class="blank"> </span>c<span class="blank _c"></span>omo<span class="blank"> </span>compue<span class="blank _c"></span>st<span class="blank _c"></span>os<span class="blank _f"> </span>direc<span class="blank _1c"></span>tamen<span class="blank _1c"></span>te<span class="blank _2"> </span>utiliz<span class="blank _1c"></span>ados<span class="blank"> </span>en<span class="blank"> </span>el<span class="blank"> </span>tratamie<span class="blank _c"></span>n<span class="blank _c"></span>to<span class="blank"> </span>de<span class="blank"> </span>est<span class="blank _c"></span>as<span class="blank _f"> </span>enfe<span class="blank _c"></span>rme<span class="blank _c"></span>dade<span class="blank _c"></span>s<span class="blank _2"> </span>en<span class="blank"> </span>animales<span class="blank _0"> </span>y</div><div class="t m1 x14 h4 y64 ffb fs2 fc0 sc0 ls33 ws53">hum<span class="blank _3"> </span>a<span class="blank _3"> </span>n<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank"> </span>.</div><div class="t m1 x13 h4 y65 ffb fs2 fc0 sc0 ls31 ws46">Fi<span class="blank"> </span>na<span class="blank"> </span>l<span class="blank"> </span>m<span class="blank _3"> </span>ente,<span class="blank _12"> </span>se<span class="blank _12"> </span>d<span class="blank"> </span>escri<span class="blank"> </span>b<span class="blank _3"> </span>en<span class="blank _f"> </span>y<span class="blank _f"> </span>pro<span class="blank"> </span>teg<span class="blank"> </span>en<span class="blank _f"> </span>tamb<span class="blank"> </span>i´<span class="blank _6"></span><span class="lsc ws57">en<span class="blank _12"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _12"> </span>m´<span class="blank _6"></span><span class="lsf ws58">eto<span class="blank _3"> </span>do<span class="blank"> </span>s<span class="blank _f"> </span>sint´<span class="blank _5"></span><span class="ls2d ws39">eticos<span class="blank _12"> </span>de<span class="blank _f"> </span>todo<span class="blank"> </span>s<span class="blank _f"> </span>los<span class="blank _12"> </span>compuestos<span class="blank _12"> </span>descritos.</span></span></span></div><div class="t m1 x14 h4 y66 ffb fs2 fc0 sc0 ls1c ws3c">3.-<span class="blank"> </span><span class="ff4 lsb ws59">Es<span class="blank _c"></span>tado<span class="blank"> </span>an<span class="blank _c"></span>terio<span class="blank _c"></span>r<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank _4"> </span>t´<span class="blank _11"></span><span class="ls19 ws3e">ecnic<span class="blank _c"></span>a</span></span></div><div class="t m1 x13 h4 y67 ffb fs2 fc0 sc0 ls19 ws5a">La<span class="blank"> </span>regulaci´<span class="blank _1b"></span><span class="lsf ws28">on<span class="blank _0"> </span>d<span class="blank"> </span>el<span class="blank _f"> </span>creci<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank"> </span>ento,<span class="blank _f"> </span>dif<span class="blank"> </span>erenci<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws5b">on<span class="blank _12"> </span>y<span class="blank _12"> </span>mu<span class="blank _c"></span>ert<span class="blank _c"></span>e<span class="blank _12"> </span>ce<span class="blank _c"></span>lular<span class="blank _0"> </span>programada<span class="blank _0"> </span>(<span class="blank _c"></span>ap<span class="blank"> </span>optosis<span class="blank _c"></span>),<span class="blank _12"> </span>tres<span class="blank _0"> </span>fen´<span class="blank _1b"></span><span class="ls1e ws5c">omenos</span></span></span></div><div class="t m1 x14 h4 y68 ffb fs2 fc0 sc0 ls1e ws5d">dire<span class="blank _c"></span>ct<span class="blank _c"></span>amen<span class="blank _1c"></span>te<span class="blank _12"> </span>relac<span class="blank _1c"></span>ionados<span class="blank"> </span>con<span class="blank _12"> </span>la<span class="blank"> </span>trans<span class="blank _c"></span>formaci´<span class="blank _1b"></span><span class="lsc ws48">on<span class="blank _0"> </span>cel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>r,<span class="blank _f"> </span>se<span class="blank _12"> </span>rea<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>za<span class="blank _12"> </span>m<span class="blank"> </span>ed<span class="blank"> </span>i<span class="blank"> </span>ante<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>comun<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws5e">on<span class="blank"> </span>en<span class="blank _1c"></span>tre<span class="blank _12"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsc ws48">el<span class="blank"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>s</span></span></span></div><div class="t m1 x14 h4 y69 ffb fs2 fc0 sc0 ls35 ws5f">at<span class="blank _19"></span>r<span class="blank _19"></span>a<span class="blank _e"></span>v<span class="blank _19"></span>´<span class="blank _1e"></span><span class="lsf ws58">es<span class="blank _f"> </span>de<span class="blank _2"> </span>com<span class="blank"> </span>pl<span class="blank _3"> </span>ejo<span class="blank"> </span>s<span class="blank _f"> </span>meca<span class="blank"> </span>n<span class="blank"> </span>i<span class="blank"> </span>sm<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>de<span class="blank _2"> </span>tran<span class="blank"> </span>sm<span class="blank"> </span>i<span class="blank"> </span>si<span class="blank"> </span>´<span class="blank _6"></span><span class="ls10 ws60">on<span class="blank"> </span>de<span class="blank"> </span>se\u02dc<span class="blank _1b"></span><span class="ls1e ws61">nale<span class="blank _c"></span>s<span class="blank _f"> </span>(Roze<span class="blank _c"></span>ngur<span class="blank _c"></span>t,<span class="blank"> </span>E.<span class="blank"> </span>1986.<span class="blank _4"> </span>Scien<span class="blank _c"></span>ce<span class="blank"> </span>234:<span class="blank _4"> </span>161-166).</span></span></span></div><div class="t m1 x14 h4 y6a ffb fs2 fc0 sc0 ls30 ws43">En<span class="blank _0"> </span>lo<span class="blank"> </span>s<span class="blank _f"> </span>´<span class="blank _1b"></span><span class="ls2d ws39">ulti<span class="blank"> </span>m<span class="blank"> </span>os<span class="blank _0"> </span>a\u02dc<span class="blank _1b"></span><span class="lsf ws58">n<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _0"> </span>se<span class="blank _12"> </span>ha<span class="blank _f"> </span>pro<span class="blank"> </span>d<span class="blank"> </span>u<span class="blank"> </span>ci<span class="blank"> </span>do<span class="blank _12"> </span>un<span class="blank _12"> </span>esp<span class="blank _3"> </span>ecta<span class="blank"> </span>cu<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _f"> </span>av<span class="blank _1c"></span>a<span class="blank"> </span>n<span class="blank"> </span>ce<span class="blank _0"> </span>en<span class="blank _12"> </span>el<span class="blank _12"> </span>con<span class="blank"> </span>o<span class="blank _3"> </span>ci<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank _3"> </span>ento<span class="blank _0"> </span>de<span class="blank _12"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _0"> </span>si<span class="blank"> </span>st<span class="blank"> </span>em<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _12"> </span>enzi<span class="blank"> </span>m<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls8 ws62">atic<span class="blank _c"></span>os</span></span></span></div><div class="t m1 x14 h4 y6b ffb fs2 fc0 sc0 ls1c ws63">in<span class="blank _c"></span>v<span class="blank _c"></span>oluc<span class="blank _c"></span>rados<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _2"> </span>la<span class="blank"> </span>gene<span class="blank _1c"></span>raci´<span class="blank _1b"></span><span class="ls2d ws4b">on<span class="blank _2"> </span>de<span class="blank _f"> </span>segundos<span class="blank _f"> </span>m<span class="blank"> </span>ensa<span class="blank _3"> </span>j<span class="blank"> </span>eros<span class="blank _2"> </span>com<span class="blank"> </span>o<span class="blank _f"> </span>respues<span class="blank _c"></span>ta<span class="blank _4"> </span>a<span class="blank _f"> </span>est<span class="blank _d"></span>´<span class="blank _e"></span><span class="ls14 ws40">\u0131mulos<span class="blank _f"> </span>que<span class="blank _f"> </span>re<span class="blank _c"></span>gul<span class="blank"> </span>an<span class="blank _f"> </span>estas<span class="blank _2"> </span>fun-</span></span></div><div class="t m1 x14 h4 y6c ffb fs2 fc0 sc0 lsf ws28">cio<span class="blank"> </span>nes<span class="blank _9"> </span>cel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>ar<span class="blank"> </span>es.<span class="blank _1f"> </span>Ejem<span class="blank"> </span>p<span class="blank"> </span>l<span class="blank"> </span>os<span class="blank _9"> </span>de<span class="blank _9"> </span>estos<span class="blank _7"> </span>si<span class="blank"> </span>stem<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _9"> </span>lo<span class="blank _9"> </span>consti<span class="blank"> </span>t<span class="blank"> </span>uyen<span class="blank _7"> </span>la<span class="blank _8"> </span>reg<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>aci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls14 ws40">o<span class="blank"> </span>n<span class="blank _9"> </span>de<span class="blank _8"> </span>la<span class="blank"> </span>s<span class="blank _8"> </span>cascadas<span class="blank _7"> </span>de<span class="blank _8"> </span>q<span class="blank"> </span>ui<span class="blank"> </span>nasas</span></div><div class="t m1 x14 h4 y6d ffb fs2 fc0 sc0 ls1e ws23">in<span class="blank _c"></span>trac<span class="blank _1c"></span>elulare<span class="blank _c"></span>s<span class="blank"> </span>(Raf-1/ME<span class="blank _c"></span>K/MA<span class="blank _c"></span>PK<span class="blank _c"></span>),<span class="blank"> </span>c<span class="blank _1c"></span>omo<span class="blank"> </span>l<span class="blank _3"> </span>a<span class="blank _4"> </span>act<span class="blank _c"></span>ividad<span class="blank"> </span>de<span class="blank _4"> </span>prot<span class="blank _c"></span>eina<span class="blank"> </span>quin<span class="blank _c"></span>asa<span class="blank"> </span>de<span class="blank _1c"></span>p<span class="blank _3"> </span>en<span class="blank _c"></span>dien<span class="blank _1c"></span>te<span class="blank _9"> </span>de<span class="blank"> </span>c<span class="blank _1c"></span>AMP<span class="blank _1"></span>,<span class="blank"> </span>la</div><div class="t m1 x14 h4 y6e ffb fs2 fc0 sc0 ls31 ws46">fo<span class="blank"> </span>sf<span class="blank"> </span>o<span class="blank _3"> </span>di<span class="blank _3"> </span>esterasa<span class="blank _2"> </span>esp<span class="blank _3"> </span>ec<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls8 ws4c">\u0131\ufb01ca<span class="blank _2"> </span>par<span class="blank _c"></span>a<span class="blank"> </span>la<span class="blank"> </span>cGMP<span class="blank"> </span>o<span class="blank"> </span>las<span class="blank"> </span>fos<span class="blank _1c"></span>folipasas<span class="blank _12"> </span><span class="ffd ls27">\u03b2</span><span class="ls28">y<span class="ffd ls29">\u03b3</span><span class="lsf ws13">esp<span class="blank"> </span>ec<span class="blank _d"></span>´<span class="blank _e"></span><span class="ls1c ws64">\u0131\ufb01c<span class="blank _c"></span>as<span class="blank _2"> </span>para<span class="blank"> </span>P<span class="blank _c"></span>Is<span class="blank"> </span>(fos<span class="blank _c"></span>fatidilinos<span class="blank _1c"></span>itoles<span class="blank _c"></span>).</span></span></span></span></div><div class="t m1 x14 h4 y6f ffb fs2 fc0 sc0 ls2f ws63">Estas<span class="blank"> </span>enzimas<span class="blank"> </span>est´<span class="blank _5"></span><span class="lsf ws58">an<span class="blank _f"> </span>regu<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _12"> </span>a<span class="blank _0"> </span>su<span class="blank _f"> </span>vez<span class="blank _0"> </span>p<span class="blank _3"> </span>o<span class="blank"> </span>r<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>act<span class="blank"> </span>i<span class="blank"> </span>v<span class="blank"> </span>i<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _12"> </span>de<span class="blank _12"> </span>recept<span class="blank"> </span>o<span class="blank"> </span>res<span class="blank _2"> </span>esp<span class="blank"> </span>ec<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls2d ws39">\u0131\ufb01cos<span class="blank _f"> </span>ubicado<span class="blank"> </span>s<span class="blank _12"> </span>en<span class="blank _0"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>membrana</span></span></div><div class="t m1 x14 h4 y70 ffb fs2 fc0 sc0 lsf ws58">celu<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _4"> </span>con<span class="blank _4"> </span>act<span class="blank"> </span>i<span class="blank"> </span>v<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank _4"> </span>tiro<span class="blank"> </span>si<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _4"> </span>qui<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank"> </span>sa<span class="blank"> </span>,<span class="blank _8"> </span>o<span class="blank _4"> </span>receptores<span class="blank _9"> </span>aco<span class="blank"> </span>pl<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _4"> </span>al<span class="blank _4"> </span>si<span class="blank"> </span>st<span class="blank"> </span>em<span class="blank"> </span>a<span class="blank _4"> </span>en<span class="blank"> </span>zi<span class="blank"> </span>m<span class="blank"> </span>´<span class="blank _5"></span><span class="lsc ws48">a<span class="blank"> </span>ti<span class="blank"> </span>co<span class="blank _4"> </span>resp<span class="blank"> </span>ect<span class="blank"> </span>i<span class="blank"> </span>vo<span class="blank _8"> </span>a<span class="blank _4"> </span>tr<span class="blank"> </span>av´<span class="blank _5"></span>es</span></div><div class="t m1 x14 h4 y71 ffb fs2 fc0 sc0 ls2d ws39">de<span class="blank _f"> </span>protei<span class="blank"> </span>nas<span class="blank _2"> </span>G,<span class="blank _2"> </span>con<span class="blank _f"> </span>capacida<span class="blank"> </span>d<span class="blank _2"> </span>de<span class="blank _f"> </span>uni<span class="blank"> </span>rse<span class="blank _2"> </span>e<span class="blank _2"> </span>hidroli<span class="blank"> </span>zar<span class="blank _f"> </span>G<span class="blank"> </span>TP<span class="blank _1c"></span>.</div><div class="t m1 x13 h4 y72 ffb fs2 fc0 sc0 lsf ws58">Una<span class="blank _2"> </span>de<span class="blank _4"> </span>la<span class="blank"> </span>s<span class="blank _f"> </span>ca<span class="blank"> </span>ra<span class="blank"> </span>cter<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls16 ws65">\u0131<span class="blank"> </span>sti<span class="blank"> </span>ca<span class="blank"> </span>s<span class="blank _4"> </span>f<span class="blank"> </span>unda<span class="blank"> </span>m<span class="blank"> </span>ental<span class="blank"> </span>es<span class="blank _2"> </span>de<span class="blank _2"> </span>muc<span class="blank _c"></span>hos<span class="blank _2"> </span>receptores<span class="blank _8"> </span>par<span class="blank"> </span>a<span class="blank _2"> </span>fa<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>crecim<span class="blank"> </span>i<span class="blank"> </span>ento<span class="blank _2"> </span>es<span class="blank _4"> </span>la<span class="blank _f"> </span>a<span class="blank"> </span>c-</span></div><div class="t m1 x14 h4 y73 ffb fs2 fc0 sc0 ls31 ws46">ti<span class="blank"> </span>vi<span class="blank _3"> </span>dad<span class="blank _f"> </span>de<span class="blank _f"> </span>tiro<span class="blank"> </span>si<span class="blank _3"> </span>na<span class="blank _f"> </span>qui<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank"> </span>sa<span class="blank _f"> </span>a<span class="blank"> </span>so<span class="blank _3"> </span>ci<span class="blank"> </span>a<span class="blank"> </span>da<span class="blank _f"> </span>a<span class="blank"> </span>l<span class="blank _f"> </span>recepto<span class="blank"> </span>r<span class="blank _4"> </span>tras<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>un<span class="blank"> </span>i<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1e ws61">on<span class="blank"> </span>al<span class="blank"> </span>ligando<span class="blank _0"> </span>(Hun<span class="blank _1c"></span>ter<span class="blank _c"></span>,<span class="blank _f"> </span>T,<span class="blank"> </span>y<span class="blank"> </span>Co<span class="blank _3"> </span>oper,<span class="blank"> </span>J.A.<span class="blank"> </span>1985.</span></div><div class="t m1 x14 h4 y74 ffb fs2 fc0 sc0 ls1e ws66">Ann<span class="blank _c"></span>.<span class="blank"> </span>Rev.<span class="blank"> </span>Bioch<span class="blank _c"></span>em.<span class="blank"> </span>54:<span class="blank _16"> </span>897-930;<span class="blank _8"> </span>Sible<span class="blank _c"></span>y<span class="blank _1"></span>,<span class="blank _8"> </span>D.R.<span class="blank _4"> </span>et<span class="blank _4"> </span>al.<span class="blank"> </span>1987.<span class="blank"> </span>Cell<span class="blank _4"> </span>48:<span class="blank _16"> </span>913-922).<span class="blank _17"> </span>Med<span class="blank _c"></span>ian<span class="blank _c"></span>te<span class="blank _4"> </span>difere<span class="blank _1c"></span>nte<span class="blank _1c"></span>s</div><div class="t m1 x14 h4 y75 ffb fs2 fc0 sc0 lsf ws58">estra<span class="blank"> </span>teg<span class="blank"> </span>i<span class="blank"> </span>a<span class="blank"> </span>s,<span class="blank _7"> </span>se<span class="blank _8"> </span>h<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank _9"> </span>identi<span class="blank"> </span>\ufb01ca<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank _8"> </span>num<span class="blank"> </span>ero<span class="blank"> </span>so<span class="blank"> </span>s<span class="blank _9"> </span>sub<span class="blank"> </span>str<span class="blank"> </span>a<span class="blank"> </span>to<span class="blank"> </span>s<span class="blank _9"> </span>i<span class="blank"> </span>ntra<span class="blank"> </span>cel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>res<span class="blank _9"> </span>de<span class="blank _8"> </span>esto<span class="blank"> </span>s<span class="blank _9"> </span>recep<span class="blank"> </span>to<span class="blank"> </span>res<span class="blank _7"> </span>ta<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _9"> </span>com<span class="blank"> </span>o<span class="blank _8"> </span>PI-</div><div class="t m1 x14 h4 y76 ffb fs2 fc0 sc0 ls6 ws67">PLC,<span class="blank"> </span><span class="ffe ls30 ws23">Sr<span class="blank _1c"></span>c<span class="blank _3"> </span>,<span class="blank"> </span>Syp,<span class="blank"> </span>Shc<span class="ffb lse ws68">,<span class="blank _4"> </span>GAP-ras<span class="blank _f"> </span>y<span class="blank _4"> </span>PI3<span class="blank"> </span>Kinas<span class="blank _1c"></span>e<span class="blank _4"> </span>(Cuadr<span class="blank _c"></span>ado,<span class="blank"> </span>A.,<span class="blank"> </span>Carn<span class="blank _c"></span>ero,<span class="blank"> </span>A<span class="blank _c"></span>.<span class="blank"> </span>y<span class="blank"> </span>Lacal,<span class="blank"> </span>J<span class="blank _c"></span>.C.<span class="blank"> </span>ras</span></span></div><div class="t m1 x15 h4 y77 ffb fs2 fc0 sc0 lse ws69">-p21<span class="blank"> </span>prot<span class="blank _c"></span>eins<span class="blank _c"></span>:</div><div class="t m1 x14 h10 y78 ffb fs2 fc0 sc0 ls2d ws39">switch<span class="blank _2"> </span>de<span class="blank _c"></span>vices<span class="blank _4"> </span>for<span class="blank _2"> </span>signal<span class="blank _2"> </span>transduction.<span class="blank _13"> </span>En<span class="blank _2"> </span>The<span class="blank _2"> </span>ras<span class="blank _2"> </span><span class="ls1e ws6a v0">superfamily<span class="blank _f"> </span>of<span class="blank _2"> </span>GTP<span class="blank _c"></span>ase<span class="blank _c"></span>s.<span class="blank"> </span>1993.<span class="blank _9"> </span>E<span class="blank _c"></span>ditore<span class="blank _1c"></span>s:<span class="blank"> </span>J.C.<span class="blank _f"> </span>Lacal</span></div><div class="t m1 x14 h4 y79 ffb fs2 fc0 sc0 ls15 ws6b">y<span class="blank _2"> </span>F.<span class="blank _4"> </span>McCorm<span class="blank"> </span>i<span class="blank _3"> </span>c<span class="blank _c"></span>k,<span class="blank _2"> </span>C<span class="blank"> </span>RC<span class="blank _2"> </span>Press).<span class="blank _14"> </span>T<span class="blank _1c"></span>ras<span class="blank _2"> </span>l<span class="blank _3"> </span>a<span class="blank _2"> </span>conexi<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls2d ws16">on<span class="blank _2"> </span>de<span class="blank _2"> </span>estas<span class="blank _4"> </span>rutas<span class="blank _2"> </span>de<span class="blank _2"> </span>se\u02dc<span class="blank _1b"></span><span class="ls1b ws6c">naliz<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls1c ws4d">on,<span class="blank _2"> </span>s<span class="blank _c"></span>e<span class="blank _2"> </span>pr<span class="blank _c"></span>o<span class="blank"> </span>duc<span class="blank _c"></span>e<span class="blank _2"> </span>la<span class="blank _2"> </span>ac<span class="blank _c"></span>tiv<span class="blank _1c"></span>aci´<span class="blank _1b"></span><span class="ls10">on</span></span></span></span></div><div class="t m1 x14 h4 y7a ffb fs2 fc0 sc0 lsf ws58">esp<span class="blank"> </span>ec<span class="blank _1"></span>´<span class="blank _a"></span>\u0131\ufb01<span class="blank"> </span>ca<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _f"> </span>fact<span class="blank"> </span>o<span class="blank"> </span>res<span class="blank _2"> </span>de<span class="blank _f"> </span>transcri<span class="blank _3"> </span>p<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1c ws6d">on,<span class="blank"> </span>bien<span class="blank"> </span>c<span class="blank _c"></span>itoplas<span class="blank _c"></span>m´<span class="blank _1b"></span><span class="ls1e ws6e">aticos<span class="blank _0"> </span>o<span class="blank"> </span>n<span class="blank _1c"></span>uclear<span class="blank _c"></span>es<span class="blank _c"></span>,<span class="blank _2"> </span>qu<span class="blank _c"></span>e<span class="blank"> </span>c<span class="blank _c"></span>on<span class="blank _c"></span>trolan<span class="blank"> </span>la<span class="blank"> </span>e<span class="blank _1c"></span>xpres<span class="blank _c"></span>i´<span class="blank _5"></span>on<span class="blank"> </span>de<span class="blank"> </span>los</span></span></div><div class="t m1 x14 h4 y7b ffb fs2 fc0 sc0 ls2d ws39">genes<span class="blank _f"> </span>re<span class="blank _c"></span>gul<span class="blank"> </span>ado<span class="blank"> </span>res<span class="blank _f"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>respuesta<span class="blank _2"> </span>celular.<span class="blank _8"> </span>Lo<span class="blank"> </span>s<span class="blank _f"> </span>oncogenes<span class="blank _2"> </span>iden<span class="blank _1c"></span>ti<span class="blank"> </span>\ufb01cado<span class="blank"> </span>s<span class="blank _f"> </span>hasta<span class="blank _f"> </span>la<span class="blank _f"> </span>fec<span class="blank _c"></span>ha<span class="blank _f"> </span>se<span class="blank _f"> </span>pueden<span class="blank _f"> </span>relacio<span class="blank"> </span>nar</div><div class="t m1 x14 h4 y7c ffb fs2 fc0 sc0 lsf ws28">di<span class="blank"> </span>recta<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _2"> </span>con<span class="blank _4"> </span>la<span class="blank _2"> </span>fun<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls2d ws39">on<span class="blank _2"> </span>de<span class="blank _2"> </span>alg<span class="blank"> </span>uno<span class="blank _f"> </span>de<span class="blank _2"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>comp<span class="blank"> </span>o<span class="blank"> </span>nente<span class="blank _c"></span>s<span class="blank _2"> </span>estructurales<span class="blank _4"> </span>de<span class="blank _f"> </span>esta<span class="blank _2"> </span>cascada<span class="blank _2"> </span>de<span class="blank _2"> </span>se<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls9 ws5b">nal<span class="blank"> </span>es.<span class="blank _7"> </span>Las</span></span></div><div class="t m1 x14 h4 y7d ffb fs2 fc0 sc0 ls36 ws6f">c´<span class="blank _6"></span><span class="ls1e ws22">elulas<span class="blank"> </span>tran<span class="blank _c"></span>sformad<span class="blank _c"></span>as<span class="blank"> </span>por<span class="blank"> </span>es<span class="blank _c"></span>tos<span class="blank"> </span>oncoge<span class="blank _c"></span>nes<span class="blank"> </span>mu<span class="blank _c"></span>es<span class="blank _c"></span>tran<span class="blank"> </span>alter<span class="blank _c"></span>acione<span class="blank _1c"></span>s<span class="blank"> </span>en<span class="blank"> </span>las<span class="blank"> </span>rutas<span class="blank"> </span>de<span class="blank"> </span>se\u02dc<span class="blank _1b"></span><span class="ls1b ws6c">n<span class="blank _c"></span>alizac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls8 ws70">on<span class="blank"> </span>utiliz<span class="blank _c"></span>adas</span></span></span></div><div class="t m1 x14 h4 y7e ffb fs2 fc0 sc0 ls37 ws71">por<span class="blank"> </span>l<span class="blank _c"></span>as<span class="blank"> </span>c<span class="blank _1"></span>´<span class="blank _5"></span><span class="lsf ws58">el<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>no<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank _3"> </span>es,<span class="blank _4"> </span>m<span class="blank"> </span>a<span class="blank"> </span>nteni<span class="blank"> </span>en<span class="blank"> </span>do<span class="blank _8"> </span>de<span class="blank _8"> </span>fo<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank _8"> </span>p<span class="blank"> </span>erm<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank"> </span>entem<span class="blank"> </span>ente<span class="blank _8"> </span>a<span class="blank"> </span>cti<span class="blank"> </span>vas<span class="blank _4"> </span>casca<span class="blank"> </span>da<span class="blank"> </span>s<span class="blank _8"> </span>qu<span class="blank"> </span>e<span class="blank _8"> </span>en<span class="blank _8"> </span>con<span class="blank"> </span>di<span class="blank"> </span>ci<span class="blank _3"> </span>on<span class="blank"> </span>es</span></div><div class="t m1 x14 h4 y7f ffb fs2 fc0 sc0 ls8 ws4c">normale<span class="blank _1c"></span>s<span class="blank"> </span>solo<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank _2"> </span>ac<span class="blank _c"></span>tiv<span class="blank _1c"></span>an<span class="blank"> </span>de<span class="blank"> </span>forma<span class="blank"> </span>tran<span class="blank _c"></span>sitor<span class="blank _c"></span>ia<span class="blank"> </span>tras<span class="blank"> </span>la<span class="blank"> </span>e<span class="blank _c"></span>stim<span class="blank _1c"></span>ulaci´<span class="blank _1b"></span><span class="ls10 ws3b">on<span class="blank"> </span>oncog<span class="blank _1c"></span>´<span class="blank _6"></span><span class="lsc ws38">eni<span class="blank"> </span>ca<span class="blank _3"> </span>.</span></span></div><div class="t m1 x13 h4 y80 ffb fs2 fc0 sc0 ls2f ws49">Una<span class="blank _12"> </span>de<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _12"> </span>rutas<span class="blank _12"> </span>m<span class="blank"> </span>eta<span class="blank"> </span>b´<span class="blank _5"></span><span class="ls31 ws46">ol<span class="blank _3"> </span>ica<span class="blank"> </span>s<span class="blank _12"> </span>co<span class="blank"> </span>ntrol<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _12"> </span>p<span class="blank _3"> </span>or<span class="blank _12"> </span>f<span class="blank"> </span>a<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _f"> </span>de<span class="blank _f"> </span>crecimi<span class="blank _3"> </span>ento<span class="blank _12"> </span>y<span class="blank _f"> </span>alt<span class="blank"> </span>era<span class="blank"> </span>da<span class="blank _f"> </span>tras<span class="blank _f"> </span>la<span class="blank _12"> </span>t<span class="blank"> </span>ra<span class="blank"> </span>nsf<span class="blank"> </span>o<span class="blank"> </span>rm<span class="blank _3"> </span>aci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10">on</span></span></div><div class="t m1 x14 h4 y81 ffb fs2 fc0 sc0 ls10 ws72">oncog<span class="blank _1c"></span>´<span class="blank _5"></span><span class="lsc ws38">en<span class="blank"> </span>i<span class="blank _3"> </span>ca<span class="blank _2"> </span>de<span class="blank _2"> </span>m´<span class="blank _5"></span><span class="ls14 ws40">as<span class="blank _2"> </span>relev<span class="blank _1c"></span>ancia<span class="blank _2"> </span>de<span class="blank _c"></span>sde<span class="blank _2"> </span>el<span class="blank _2"> </span>punto<span class="blank _f"> </span>de<span class="blank _2"> </span>vista<span class="blank _f"> </span>de<span class="blank _2"> </span>la<span class="blank _f"> </span>regula<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls1c ws73">on<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank"> </span>prolifer<span class="blank _1c"></span>aci´<span class="blank _1b"></span><span class="lsc ws57">o<span class="blank"> </span>n<span class="blank _2"> </span>celul<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>cons-</span></span></span></span></div><div class="t m1 x14 h4 y82 ffb fs2 fc0 sc0 ls2d ws39">tituye<span class="blank _4"> </span>el<span class="blank _4"> </span>m<span class="blank"> </span>etab<span class="blank _3"> </span>oli<span class="blank"> </span>sm<span class="blank"> </span>o<span class="blank _4"> </span>de<span class="blank _4"> </span>f<span class="blank"> </span>osf<span class="blank"> </span>ol<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls1c ws4f">\u0131pidos<span class="blank _c"></span>,<span class="blank _2"> </span>en<span class="blank _8"> </span>part<span class="blank _c"></span>icu<span class="blank _c"></span>lar<span class="blank _2"> </span>de<span class="blank _8"> </span>fosfat<span class="blank _c"></span>idil-inos<span class="blank _c"></span>itol<span class="blank _c"></span>es<span class="blank"> </span>(P<span class="blank _1c"></span>Is)<span class="blank _4"> </span>y<span class="blank _8"> </span>fosfat<span class="blank _c"></span>idilcolin<span class="blank _c"></span>a<span class="blank"> </span>(P<span class="blank _c"></span>C)</span></div><div class="t m1 x14 h4 y83 ffb fs2 fc0 sc0 ls1e ws74">(B<span class="blank _c"></span>err<span class="blank _1c"></span>i<span class="blank _3"> </span>dge<span class="blank _1c"></span>,<span class="blank _4"> </span>M.J.,<span class="blank _2"> </span>y<span class="blank _4"> </span>Irvin<span class="blank _c"></span>e,<span class="blank"> </span>R.F.<span class="blank"> </span>1989.<span class="blank _13"> </span>Natur<span class="blank _c"></span>e<span class="blank _4"> </span>341:<span class="blank _9"> </span>197-205;<span class="blank"> </span>Pe<span class="blank _c"></span>lec<span class="blank _1c"></span>h,<span class="blank _4"> </span>S.L.<span class="blank"> </span>y<span class="blank"> </span>V<span class="blank _1c"></span>ance<span class="blank _1c"></span>,<span class="blank _4"> </span>D.E.<span class="blank _2"> </span>1989.<span class="blank _13"> </span>T<span class="blank _1c"></span>re<span class="blank _c"></span>nds<span class="blank"> </span>in</div><div class="t m1 x14 h4 y84 ffb fs2 fc0 sc0 ls1e ws75">Bioc<span class="blank _c"></span>hem.<span class="blank"> </span>Sci.<span class="blank"> </span>14:<span class="blank"> </span>28-30.).<span class="blank"> </span>La<span class="blank _2"> </span>hidr´<span class="blank _1b"></span><span class="ls1c ws76">olisis<span class="blank _f"> </span>de<span class="blank _2"> </span>fosfat<span class="blank _c"></span>idil-in<span class="blank _c"></span>ositol<span class="blank"> </span>b<span class="blank _c"></span>ifosfat<span class="blank _c"></span>o<span class="blank _2"> </span>(P<span class="blank _1c"></span>IP</span></div><div class="t m1 x16 h11 y85 ff5 fs5 fc0 sc0 ls2a">2<span class="ffb fs2 lsc ws48 v3">)<span class="blank _2"> </span>m<span class="blank"> </span>edi<span class="blank"> </span>a<span class="blank"> </span>nte<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>a<span class="blank"> </span>cci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1e ws77">on<span class="blank"> </span>de<span class="blank"> </span>las</span></span></div><div class="t m1 x14 h4 y86 ffb fs2 fc0 sc0 ls32 ws49">PLCs,<span class="blank _8"> </span>ori<span class="blank _3"> </span>gina<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _8"> </span>form<span class="blank _3"> </span>aci´<span class="blank _5"></span><span class="ls8 ws4c">on<span class="blank _2"> </span>de<span class="blank _4"> </span>inos<span class="blank _c"></span>itol-1,4,5-<span class="blank _1c"></span>trifosfat<span class="blank _c"></span>o<span class="blank"> </span>(IP</span></div><div class="t m1 x17 h11 y87 ff5 fs5 fc0 sc0 ls2b">3<span class="ffb fs2 ls1e ws74 v3">)<span class="blank _2"> </span>y<span class="blank _4"> </span>1,2-diacilglic<span class="blank _c"></span>er<span class="blank _c"></span>ol<span class="blank"> </span>(D<span class="blank _c"></span>A<span class="blank _c"></span>G).<span class="blank"> </span>La<span class="blank _4"> </span>hidr´<span class="blank _1b"></span><span class="ls1b ws78">olisis<span class="blank"> </span>de</span></span></div><div class="t m1 x14 h4 y88 ffb fs2 fc0 sc0 ls32 ws49">PC<span class="blank _12"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _0"> </span>una<span class="blank _12"> </span>PL<span class="blank"> </span>D<span class="blank _12"> </span>o<span class="blank"> </span>ri<span class="blank _3"> </span>gi<span class="blank"> </span>na<span class="blank _0"> </span>col<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _12"> </span>y<span class="blank _0"> </span>´<span class="blank _5"></span><span class="ls8 ws79">acid<span class="blank _c"></span>o<span class="blank"> </span>fosfat<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls1c ws7a">\u0131dico<span class="blank _20"> </span>(P<span class="blank _1"></span>A)<span class="blank _c"></span>,<span class="blank"> </span>q<span class="blank _c"></span>ue<span class="blank _0"> </span>poste<span class="blank _1c"></span>riorme<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank"> </span>se<span class="blank"> </span>c<span class="blank _1c"></span>onvie<span class="blank _1c"></span>rten<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>fos<span class="blank _c"></span>forilc<span class="blank _c"></span>olina</span></span></div><div class="t m1 x18 h4 y89 ffb fs2 fc0 sc0 ls9">2</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf3" class="pf w0 h0" data-page-no="3"><div class="pc pc3 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x19 y8a w3 h12" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg3.png"><div class="t m1 x1a he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x1b hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x1c hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x1c hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x1c hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x1c hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x1c hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x1c hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x1c hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x1c hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x1c hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x1c hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x1c hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x1d h4 y51 ffb fs2 fc0 sc0 lsf ws58">(PCh<span class="blank"> </span>o<span class="blank"> </span>)<span class="blank _2"> </span>y<span class="blank _f"> </span>DAG<span class="blank _f"> </span>resp<span class="blank _3"> </span>ecti<span class="blank"> </span>vamente.</div><div class="t m1 x14 h4 y8b ffb fs2 fc0 sc0 ls31 ws46">Entre<span class="blank _9"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _9"> </span>di<span class="blank"> </span>versos<span class="blank _7"> </span>com<span class="blank _3"> </span>p<span class="blank"> </span>o<span class="blank"> </span>nentes<span class="blank _7"> </span>estru<span class="blank"> </span>ctu<span class="blank"> </span>ra<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _14"> </span>que<span class="blank _9"> </span>i<span class="blank _3"> </span>ntegran<span class="blank _9"> </span>l<span class="blank"> </span>a<span class="blank _7"> </span>casca<span class="blank"> </span>da<span class="blank _7"> </span>d<span class="blank"> </span>e<span class="blank _7"> </span>se\u02dc<span class="blank _5"></span>nal<span class="blank"> </span>es<span class="blank _7"> </span>i<span class="blank"> </span>ntracel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>res,<span class="blank _13"> </span>l<span class="blank _3"> </span>a</div><div class="t m1 x1d h13 y8c ffb fs2 fc0 sc0 ls2d ws39">proteina<span class="blank _4"> </span>p2-ra<span class="blank"> </span>s<span class="blank _4"> </span><span class="ls1e ws7b v0">o<span class="blank _3"> </span>cup<span class="blank _c"></span>a<span class="blank"> </span>un<span class="blank"> </span>lugar<span class="blank _2"> </span>de<span class="blank _c"></span>stac<span class="blank _1c"></span>ado.<span class="blank _17"> </span>La<span class="blank"> </span>e<span class="blank _c"></span>viden<span class="blank _c"></span>cia<span class="blank"> </span>m´<span class="blank _1b"></span><span class="ls10 ws7c">as<span class="blank"> </span>s´<span class="blank _1b"></span><span class="ls1c ws7d">olida<span class="blank"> </span>que<span class="blank"> </span>implic<span class="blank _1c"></span>a<span class="blank"> </span>a<span class="blank"> </span>es<span class="blank _1c"></span>ta<span class="blank _8"> </span>prote<span class="blank _1c"></span>i<span class="blank _3"> </span>n<span class="blank _c"></span>a<span class="blank _4"> </span>en<span class="blank"> </span>los</span></span></span></div><div class="t m1 x1d h4 y8d ffb fs2 fc0 sc0 lsf ws58">pro<span class="blank _3"> </span>ceso<span class="blank"> </span>s<span class="blank _2"> </span>de<span class="blank _2"> </span>regul<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1c ws7e">on<span class="blank"> </span>de<span class="blank _f"> </span>la<span class="blank _f"> </span>pr<span class="blank _c"></span>olifer<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls2d ws39">on<span class="blank _12"> </span>celul<span class="blank"> </span>ar<span class="blank _f"> </span>i<span class="blank"> </span>nduci<span class="blank"> </span>da<span class="blank _f"> </span>po<span class="blank"> </span>r<span class="blank _2"> </span>factores<span class="blank _f"> </span>de<span class="blank _f"> </span>crecimiento<span class="blank _f"> </span>proviene<span class="blank _f"> </span>del<span class="blank _f"> </span>hec<span class="blank _c"></span>ho</span></span></div><div class="t m1 x1d h4 y8e ffb fs2 fc0 sc0 ls31 ws7f">de<span class="blank _4"> </span>que<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>mi<span class="blank"> </span>croi<span class="blank"> </span>nyecci´<span class="blank _5"></span><span class="ls10 ws80">on<span class="blank _4"> </span>de<span class="blank _c"></span>l<span class="blank _4"> </span>an<span class="blank _c"></span>ticu<span class="blank _c"></span>er<span class="blank _c"></span>po<span class="blank _4"> </span>mono<span class="blank"> </span>clonal<span class="blank _2"> </span>Y-13-259,<span class="blank _2"> </span>que<span class="blank _2"> </span>act´<span class="blank _1b"></span><span class="ls2f ws16">ua<span class="blank _4"> </span>con<span class="blank _c"></span>tra<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>proteina<span class="blank _4"> </span>p21<span class="blank"> </span>-<span class="blank"> </span>ras</span></span></div><div class="t m1 x1e h4 y8f ffb fs2 fc0 sc0 ls34 ws54">,e<span class="blank _b"></span>s</div><div class="t m1 x1d h4 y90 ffb fs2 fc0 sc0 lsc ws38">cap<span class="blank"> </span>a<span class="blank"> </span>z<span class="blank _2"> </span>de<span class="blank _f"> </span>bl<span class="blank"> </span>o<span class="blank _3"> </span>q<span class="blank"> </span>u<span class="blank"> </span>ea<span class="blank _3"> </span>r<span class="blank _f"> </span>la<span class="blank _f"> </span>a<span class="blank"> </span>cci<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls8 ws81">on<span class="blank _f"> </span>mitog<span class="blank _1c"></span>´<span class="blank _6"></span>enic<span class="blank _1c"></span>a<span class="blank _12"> </span>del<span class="blank _f"> </span>s<span class="blank _c"></span>uer<span class="blank _c"></span>o<span class="blank _f"> </span>(Mulcah<span class="blank _1c"></span>y<span class="blank _1"></span>,<span class="blank _f"> </span>L.S.<span class="blank _12"> </span>et<span class="blank _12"> </span>al.<span class="blank"> </span>1985.<span class="blank"> </span>Natur<span class="blank _c"></span>e<span class="blank _f"> </span>313:<span class="blank"> </span>241-243.)<span class="blank _c"></span>.<span class="blank _2"> </span>Asi-</span></div><div class="t m1 x1d h14 y91 ffb fs2 fc0 sc0 ls31 ws46">mi<span class="blank"> </span>sm<span class="blank _3"> </span>o,<span class="blank _f"> </span>el<span class="blank _2"> </span>a<span class="blank"> </span>nti<span class="blank"> </span>cuerp<span class="blank _3"> </span>o<span class="blank _4"> </span>Y13<span class="blank"> </span>-<span class="blank"> </span>2<span class="blank"> </span>5<span class="blank"> </span>9<span class="blank _2"> </span>es<span class="blank _2"> </span>capa<span class="blank"> </span>z<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>revertir<span class="blank _4"> </span>la<span class="blank _2"> </span>tran<span class="blank"> </span>sf<span class="blank"> </span>o<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls2f ws16">o<span class="blank"> </span>n<span class="blank _2"> </span>inducida<span class="blank _2"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _2"> </span>ras<span class="blank _2"> </span><span class="ls10 ws3d v0">y<span class="blank"> </span>otros<span class="blank"> </span>oncoge<span class="blank _1c"></span>nes</span></span></div><div class="t m1 x1d h4 y92 ffb fs2 fc0 sc0 ls1e ws82">(Smit<span class="blank _c"></span>h,<span class="blank _12"> </span>M.R.<span class="blank _f"> </span>et<span class="blank _f"> </span>al.<span class="blank"> </span>1986.<span class="blank"> </span>Nat<span class="blank _c"></span>ure<span class="blank _f"> </span>320:<span class="blank"> </span>540-543).<span class="blank"> </span>P<span class="blank _c"></span>ues<span class="blank _1c"></span>to<span class="blank _2"> </span>que<span class="blank _f"> </span>e<span class="blank _c"></span>sta<span class="blank _f"> </span>inhibic<span class="blank _c"></span>i´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _12"> </span>no<span class="blank _2"> </span>se<span class="blank _f"> </span>consig<span class="blank"> </span>ue<span class="blank _f"> </span>con<span class="blank _2"> </span>todos<span class="blank _2"> </span>los</span></div><div class="t m1 x1d h4 y93 ffb fs2 fc0 sc0 ls14 ws40">oncogenes<span class="blank _2"> </span>ensay<span class="blank _1c"></span>a<span class="blank"> </span>dos,<span class="blank _4"> </span>puede<span class="blank _2"> </span>ser<span class="blank _4"> </span>consec<span class="blank _c"></span>uencia<span class="blank _4"> </span>de<span class="blank _4"> </span>que,<span class="blank _2"> </span>aquell<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>que<span class="blank _2"> </span>escapan<span class="blank _4"> </span>a<span class="blank _2"> </span>la<span class="blank _4"> </span>inhibi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls10 ws5b">on<span class="blank _2"> </span>por<span class="blank _2"> </span>Y13-259,</span></div><div class="t m1 x1d h15 y94 ffb fs2 fc0 sc0 lsf ws58">se<span class="blank _f"> </span>en<span class="blank"> </span>cu<span class="blank"> </span>entran<span class="blank _4"> </span>en<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>mi<span class="blank"> </span>sm<span class="blank"> </span>a<span class="blank _2"> </span>casca<span class="blank"> </span>da<span class="blank _2"> </span>d<span class="blank"> </span>etr´<span class="blank _5"></span><span class="ls10 ws83">as<span class="blank _2"> </span>de<span class="blank"> </span>ras<span class="blank"> </span><span class="ls8 ws4b v0">o<span class="blank _f"> </span>que<span class="blank _2"> </span>ocupan<span class="blank _f"> </span>rut<span class="blank _c"></span>as<span class="blank _f"> </span>alter<span class="blank _1c"></span>nativ<span class="blank _1c"></span>as.</span></span></div><div class="t m1 x14 h4 y95 ffb fs2 fc0 sc0 ls2d ws39">Existe<span class="blank _2"> </span>abundante<span class="blank _2"> </span>i<span class="blank"> </span>nf<span class="blank"> </span>orm<span class="blank"> </span>a<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls1e ws84">on<span class="blank"> </span>que<span class="blank _2"> </span>e<span class="blank _c"></span>stab<span class="blank _c"></span>lec<span class="blank _c"></span>e<span class="blank _4"> </span>una<span class="blank _2"> </span>c<span class="blank _c"></span>lara<span class="blank _f"> </span>conexi´<span class="blank _1b"></span><span class="lsf ws58">on<span class="blank _2"> </span>entre<span class="blank _4"> </span>f<span class="blank"> </span>a<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _4"> </span>de<span class="blank _2"> </span>creci<span class="blank _3"> </span>mi<span class="blank _3"> </span>ento,<span class="blank _4"> </span>m<span class="blank _3"> </span>eta-</span></span></div><div class="t m1 x1d h4 y96 ffb fs2 fc0 sc0 ls1b ws44">bolismo<span class="blank _20"> </span>fosfolip<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls8 ws85">\u0131dico<span class="blank"> </span>y<span class="blank"> </span>oncoge<span class="blank _c"></span>nes<span class="blank _1c"></span>.<span class="blank _9"> </span>As<span class="blank _d"></span>´<span class="blank _b"></span><span class="lsb ws5a">\u0131,<span class="blank _f"> </span>en<span class="blank"> </span>c<span class="blank _1"></span>´<span class="blank _5"></span><span class="ls10 ws86">elulas<span class="blank"> </span>trans<span class="blank _c"></span>formadas<span class="blank"> </span>por<span class="blank"> </span><span class="ffe ls9 ws30">r<span class="blank _c"></span>as,<span class="blank"> </span>src,<span class="blank"> </span>sis<span class="blank"> </span>y<span class="blank"> </span>f<span class="blank _3"> </span>ms<span class="ffb ls8 ws87">,<span class="blank _12"> </span>los<span class="blank"> </span>niv<span class="blank _c"></span>ele<span class="blank _c"></span>s<span class="blank _12"> </span>basale<span class="blank _1c"></span>s</span></span></span></span></span></div><div class="t m1 x1d h4 y97 ffb fs2 fc0 sc0 ls1c ws88">de<span class="blank _f"> </span>difere<span class="blank _1c"></span>nt<span class="blank _c"></span>es<span class="blank _2"> </span>metabolitos<span class="blank _f"> </span>fosfolip<span class="blank _d"></span>´<span class="blank _b"></span>\u0131dicos<span class="blank _12"> </span>es<span class="blank _c"></span>t´<span class="blank _1b"></span><span class="ls1e ws89">a,<span class="blank _4"> </span>de<span class="blank"> </span>forma<span class="blank _f"> </span>cons<span class="blank _c"></span>titu<span class="blank _c"></span>tiv<span class="blank _1c"></span>a,<span class="blank"> </span>por<span class="blank"> </span>en<span class="blank _c"></span>cima<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>los<span class="blank _f"> </span>que<span class="blank"> </span>pre<span class="blank _c"></span>se<span class="blank _c"></span>nt<span class="blank _c"></span>an<span class="blank _4"> </span>las</span></div><div class="t m1 x1d h4 y98 ffb fs2 fc0 sc0 ls36 ws6f">c´<span class="blank _6"></span><span class="ls1e ws1b">elulas<span class="blank"> </span>normale<span class="blank _c"></span>s<span class="blank"> </span>(<span class="blank _c"></span>W<span class="blank _1c"></span>olfman,<span class="blank _f"> </span>A.<span class="blank"> </span>y<span class="blank _4"> </span>Mac<span class="blank _c"></span>ara,<span class="blank"> </span>I.G.<span class="blank"> </span>N<span class="blank _c"></span>ature<span class="blank"> </span>325:<span class="blank _7"> </span>359-361;<span class="blank"> </span>W<span class="blank _1c"></span>olfman,<span class="blank _f"> </span>A.<span class="blank"> </span>et<span class="blank"> </span>al.<span class="blank _14"> </span>1987.<span class="blank _14"> </span>J<span class="blank _c"></span>.<span class="blank _4"> </span>Biol.</span></div><div class="t m1 x1d h4 y99 ffb fs2 fc0 sc0 ls10 ws8a">Chem.<span class="blank _16"> </span>262:<span class="blank _14"> </span>16546-16552;<span class="blank"> </span>Lac<span class="blank _c"></span>al,<span class="blank _4"> </span>J.C.<span class="blank"> </span>et<span class="blank"> </span>al.<span class="blank _17"> </span>1987.<span class="blank _17"> </span>Nat<span class="blank _c"></span>ure<span class="blank _c"></span>:<span class="blank _14"> </span>330:<span class="blank _16"> </span>269-272;<span class="blank"> </span>Fle<span class="blank _c"></span>isc<span class="blank _1c"></span>hman,<span class="blank"> </span>L.<span class="blank"> </span>et<span class="blank _8"> </span>al.<span class="blank _16"> </span>1994.</div><div class="t m1 x1d h4 y9a ffb fs2 fc0 sc0 ls1e ws1c">Sc<span class="blank _c"></span>ienc<span class="blank _c"></span>e<span class="blank"> </span>231:<span class="blank _13"> </span>407-410).<span class="blank _14"> </span>P<span class="blank _1c"></span>or<span class="blank"> </span>otra<span class="blank"> </span>p<span class="blank _c"></span>arte<span class="blank _c"></span>,<span class="blank _4"> </span>la<span class="blank"> </span>PI3K<span class="blank"> </span>ha<span class="blank"> </span>s<span class="blank _1c"></span>i<span class="blank _3"> </span>do<span class="blank"> </span>id<span class="blank _c"></span>en<span class="blank _1c"></span>ti\ufb01cad<span class="blank _c"></span>a<span class="blank"> </span>como<span class="blank _2"> </span>un<span class="blank"> </span>s<span class="blank _c"></span>ubs<span class="blank _c"></span>trat<span class="blank _c"></span>o<span class="blank _4"> </span>frec<span class="blank _c"></span>uen<span class="blank _1c"></span>te<span class="blank _4"> </span>de<span class="blank"> </span>la</div><div class="t m1 x1d h16 y9b ffb fs2 fc0 sc0 ls2d ws39">proteina<span class="blank _f"> </span>R<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span><span class="ls1e ws82 v0">(Rodrigue<span class="blank _c"></span>z-V<span class="blank _c"></span>iciana,<span class="blank _12"> </span>P<span class="blank _1"></span>.<span class="blank _f"> </span>et<span class="blank _f"> </span>al.<span class="blank"> </span>Natur<span class="blank _c"></span>e<span class="blank _2"> </span>370:<span class="blank"> </span>527-532).<span class="blank _2"> </span>Estos<span class="blank _f"> </span>res<span class="blank _c"></span>ultados<span class="blank _f"> </span>s<span class="blank _c"></span>ugier<span class="blank _c"></span>en<span class="blank _2"> </span>la<span class="blank _f"> </span>e<span class="blank _c"></span>xist<span class="blank _c"></span>enc<span class="blank _1c"></span>ia</span></div><div class="t m1 x1d h4 y9c ffb fs2 fc0 sc0 ls2d ws39">de<span class="blank _f"> </span>di<span class="blank"> </span>f<span class="blank"> </span>eren<span class="blank _c"></span>tes<span class="blank _2"> </span>ni<span class="blank"> </span>veles<span class="blank _2"> </span>de<span class="blank _f"> </span>regula<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls8 ws50">on<span class="blank _2"> </span>de<span class="blank _1c"></span>l<span class="blank _4"> </span>met<span class="blank _c"></span>abolismo<span class="blank _f"> </span>de<span class="blank _f"> </span>fosfol<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls1c ws63">\u0131pidos<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _2"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls10 ws5b">elulas<span class="blank _2"> </span>tr<span class="blank _c"></span>ansfor<span class="blank _c"></span>madas<span class="blank _f"> </span>p<span class="blank"> </span>or<span class="blank _f"> </span>oncoge-</span></span></span></div><div class="t m1 x1d h4 y9d ffb fs2 fc0 sc0 ls14 ws8b">nes;<span class="blank _9"> </span>de<span class="blank"> </span>aqu<span class="blank _d"></span>´<span class="blank _e"></span><span class="lsf ws28">\u0131<span class="blank _4"> </span>la<span class="blank _8"> </span>i<span class="blank"> </span>m<span class="blank"> </span>p<span class="blank _3"> </span>o<span class="blank"> </span>rta<span class="blank"> </span>nci<span class="blank"> </span>a<span class="blank _8"> </span>del<span class="blank _9"> </span>cono<span class="blank _3"> </span>ci<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank"> </span>ento<span class="blank _4"> </span>d<span class="blank"> </span>e<span class="blank _8"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _8"> </span>fa<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _9"> </span>que<span class="blank _9"> </span>intervi<span class="blank"> </span>enen<span class="blank _9"> </span>en<span class="blank _8"> </span>l<span class="blank"> </span>a<span class="blank _8"> </span>reg<span class="blank"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws8c">on<span class="blank"> </span>de<span class="blank _8"> </span>es<span class="blank _c"></span>tas</span></span></div><div class="t m1 x1d h4 y9e ffb fs2 fc0 sc0 ls32 ws49">rutas<span class="blank _2"> </span>metab´<span class="blank _5"></span><span class="ls8 ws56">olicas<span class="blank"> </span>en<span class="blank _f"> </span>la<span class="blank _f"> </span>trans<span class="blank _c"></span>formac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 ws3b">on<span class="blank"> </span>celular.</span></span></div><div class="t m1 x14 h4 y9f ffb fs2 fc0 sc0 ls2d ws39">En<span class="blank _12"> </span>estudios<span class="blank _f"> </span>ante<span class="blank _c"></span>rio<span class="blank"> </span>res<span class="blank _12"> </span>de<span class="blank _12"> </span>a<span class="blank"> </span>l<span class="blank"> </span>guno<span class="blank"> </span>s<span class="blank _12"> </span>inve<span class="blank _c"></span>stigado<span class="blank"> </span>res<span class="blank _12"> </span>de<span class="blank _f"> </span>es<span class="blank _c"></span>ta<span class="blank _f"> </span>paten<span class="blank _c"></span>te<span class="blank _f"> </span>se<span class="blank _0"> </span>h<span class="blank"> </span>a<span class="blank _f"> </span>observ<span class="blank _1c"></span>ado<span class="blank _12"> </span>que,<span class="blank _f"> </span>en<span class="blank _12"> </span>c´<span class="blank _1b"></span><span class="ls10 ws86">elulas<span class="blank"> </span>trans<span class="blank _c"></span>-</span></div><div class="t m1 x1d h17 ya0 ffb fs2 fc0 sc0 ls10 ws5b">formadas<span class="blank _0"> </span>p<span class="blank"> </span>or<span class="blank _f"> </span>el<span class="blank _f"> </span>oncog<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls31 ws46">en<span class="blank _2"> </span>ras<span class="ls1c ws8d v0">,<span class="blank _f"> </span>los<span class="blank"> </span>nive<span class="blank _1c"></span>les<span class="blank _f"> </span>de<span class="blank"> </span>DA<span class="blank _1c"></span>G<span class="blank _f"> </span>y<span class="blank _12"> </span>fosforilc<span class="blank _c"></span>olina<span class="blank"> </span>(P<span class="blank _c"></span>Cho)<span class="blank"> </span>est<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls1e ws80">an<span class="blank _f"> </span>aumen<span class="blank _1c"></span>tados<span class="blank _12"> </span>res<span class="blank _c"></span>pect<span class="blank _c"></span>o<span class="blank _2"> </span>a<span class="blank _f"> </span>los</span></span></span></div><div class="t m1 x1d h4 ya1 ffb fs2 fc0 sc0 ls14 ws40">niveles<span class="blank _0"> </span>de<span class="blank _f"> </span>c´<span class="blank _5"></span><span class="ls2d ws39">elulas<span class="blank _f"> </span>normal<span class="blank"> </span>es,<span class="blank _f"> </span>a<span class="blank _12"> </span>p<span class="blank _3"> </span>esar<span class="blank _f"> </span>de<span class="blank _f"> </span>que<span class="blank _f"> </span>los<span class="blank _12"> </span>ni<span class="blank"> </span>veles<span class="blank _12"> </span>basal<span class="blank"> </span>es<span class="blank _12"> </span>de<span class="blank _f"> </span>i<span class="blank"> </span>nosi<span class="blank"> </span>tol<span class="blank"> </span>es<span class="blank _f"> </span>fosfatos<span class="blank _f"> </span>(IPs)<span class="blank _f"> </span>son<span class="blank _12"> </span>compa<span class="blank"> </span>rabl<span class="blank"> </span>es</span></div><div class="t m1 x1d h4 ya2 ffb fs2 fc0 sc0 ls38 ws8e">al<span class="blank _a"></span>o<span class="blank _a"></span>s<span class="blank _c"></span>d<span class="blank _a"></span>el<span class="blank _a"></span>a<span class="blank _a"></span>sc<span class="blank _b"></span>´<span class="blank _1d"></span><span class="ls1e ws22">e<span class="blank _c"></span>lulas<span class="blank"> </span>normale<span class="blank _1c"></span>s<span class="blank"> </span>(Lacal,<span class="blank"> </span>J.C<span class="blank"> </span>et<span class="blank"> </span>al.<span class="blank _16"> </span>1987,<span class="blank"> </span>Natur<span class="blank _c"></span>e<span class="blank"> </span>330:<span class="blank _14"> </span>269-272)<span class="blank _c"></span>.<span class="blank _14"> </span>La<span class="blank _4"> </span>produc<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="ls10 ws52">on<span class="blank"> </span>de<span class="blank _4"> </span>DA<span class="blank _1c"></span>G<span class="blank"> </span>y</span></span></div><div class="t m1 x1d h4 ya3 ffb fs2 fc0 sc0 ls2d ws39">PCho<span class="blank _12"> </span>proviene<span class="blank _12"> </span>de<span class="blank _f"> </span>la<span class="blank _12"> </span>acti<span class="blank"> </span>v<span class="blank _c"></span>aci´<span class="blank _5"></span><span class="ls14 ws8f">on<span class="blank"> </span>de<span class="blank _f"> </span>una<span class="blank _12"> </span>PC-PLD<span class="blank _f"> </span>que<span class="blank _12"> </span>genera<span class="blank _f"> </span>´<span class="blank _1b"></span><span class="ls8 ws79">acido<span class="blank"> </span>fos<span class="blank _c"></span>fat<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1c ws88">\u0131dico<span class="blank _20"> </span>(P<span class="blank _1"></span>A)<span class="blank _12"> </span>y<span class="blank _12"> </span>colina,<span class="blank _0"> </span>que<span class="blank _0"> </span>p<span class="blank"> </span>oste<span class="blank _c"></span>rior<span class="blank _c"></span>-</span></span></span></div><div class="t m1 x1d h4 ya4 ffb fs2 fc0 sc0 ls10 ws83">men<span class="blank _1c"></span>te<span class="blank"> </span>se<span class="blank"> </span>c<span class="blank _c"></span>on<span class="blank _c"></span>viert<span class="blank _c"></span>en<span class="blank"> </span>en<span class="blank"> </span>DA<span class="blank _1c"></span>G<span class="blank"> </span>y<span class="blank"> </span>PCho<span class="blank"> </span>por<span class="blank _2"> </span>acc<span class="blank _1c"></span>i<span class="blank _3"> </span>´<span class="blank _1b"></span><span class="ls1c ws64">on<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank"> </span>P<span class="blank _1"></span>A-hidr<span class="blank _c"></span>olasa<span class="blank"> </span>y<span class="blank"> </span>la<span class="blank"> </span>c<span class="blank _1c"></span>olina<span class="blank"> </span>quinas<span class="blank _c"></span>a,<span class="blank"> </span>re<span class="blank _c"></span>spec<span class="blank _1c"></span>tiv<span class="blank _1c"></span>amen<span class="blank _1c"></span>te</span></div><div class="t m1 x1d h4 ya5 ffb fs2 fc0 sc0 ls10 ws2b">(Car<span class="blank _c"></span>ner<span class="blank _c"></span>o,<span class="blank _2"> </span>A.,<span class="blank"> </span>Cuad<span class="blank _c"></span>rado,<span class="blank"> </span>A.,<span class="blank"> </span>d<span class="blank _c"></span>el<span class="blank"> </span>Pe<span class="blank _1c"></span>so,<span class="blank _2"> </span>L.<span class="blank"> </span>y<span class="blank"> </span>Lacal,<span class="blank"> </span>J<span class="blank _c"></span>.C.<span class="blank"> </span>1994.<span class="blank _8"> </span>Onc<span class="blank _c"></span>ogene<span class="blank"> </span>9:1387-1395).</div><div class="t m1 x14 h4 ya6 ffb fs2 fc0 sc0 ls8 ws90">Es<span class="blank _c"></span>tas<span class="blank"> </span>c<span class="blank _1c"></span>onclus<span class="blank _c"></span>iones<span class="blank"> </span>se<span class="blank _20"> </span>basan<span class="blank"> </span>en<span class="blank"> </span>la<span class="blank _20"> </span>obse<span class="blank _c"></span>rv<span class="blank _1"></span>aci´<span class="blank _1b"></span><span class="ls18 ws91">on<span class="blank _12"> </span>de<span class="blank"> </span>que<span class="blank"> </span>en<span class="blank"> </span>c´<span class="blank _1b"></span><span class="lsf ws58">el<span class="blank _3"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _0"> </span>esti<span class="blank _3"> </span>mul<span class="blank"> </span>a<span class="blank"> </span>da<span class="blank"> </span>s<span class="blank _12"> </span>co<span class="blank"> </span>n<span class="blank _12"> </span>su<span class="blank"> </span>ero<span class="blank _f"> </span>o<span class="blank _12"> </span>fa<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _12"> </span>d<span class="blank"> </span>e<span class="blank _12"> </span>cre-</span></span></div><div class="t m1 x1d h4 ya7 ffb fs2 fc0 sc0 ls2d ws39">cimi<span class="blank"> </span>ento<span class="blank _f"> </span>indivi<span class="blank"> </span>dua<span class="blank"> </span>l<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _0"> </span>se<span class="blank _2"> </span>produce<span class="blank _2"> </span>una<span class="blank _2"> </span>subida<span class="blank _2"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>os<span class="blank _f"> </span>ni<span class="blank"> </span>veles<span class="blank _f"> </span>intracelulares<span class="blank _2"> </span>de<span class="blank _2"> </span>fosforil<span class="blank"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _f"> </span>(PCho).<span class="blank _8"> </span>A</div><div class="t m1 x1d h4 ya8 ffb fs2 fc0 sc0 lsc ws21">ti<span class="blank"> </span>emp<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _12"> </span>p<span class="blank"> </span>eq<span class="blank"> </span>ue<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="lsf ws58">no<span class="blank"> </span>s,<span class="blank _2"> </span>co<span class="blank"> </span>nta<span class="blank"> </span>do<span class="blank"> </span>s<span class="blank _2"> </span>desde<span class="blank _2"> </span>el<span class="blank _f"> </span>i<span class="blank"> </span>ni<span class="blank _3"> </span>cio<span class="blank _f"> </span>del<span class="blank _2"> </span>est<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls2f ws16">\u0131<span class="blank"> </span>mul<span class="blank"> </span>o,<span class="blank _f"> </span>(m<span class="blank"> </span>enos<span class="blank _f"> </span>de<span class="blank _f"> </span>5<span class="blank _f"> </span>m<span class="blank"> </span>i<span class="blank"> </span>nutos)<span class="blank _12"> </span>se<span class="blank _2"> </span>produce<span class="blank _2"> </span>un<span class="blank _f"> </span>incremen<span class="blank _c"></span>to</span></span></div><div class="t m1 x1d h4 ya9 ffb fs2 fc0 sc0 ls10 ws5b">de<span class="blank _2"> </span>PCho<span class="blank _2"> </span>tr<span class="blank _c"></span>ansitor<span class="blank _c"></span>io,<span class="blank _4"> </span>y<span class="blank _2"> </span>a<span class="blank _4"> </span>tiempos<span class="blank _2"> </span>largos<span class="blank _2"> </span>(m´<span class="blank _1b"></span><span class="ls8 ws1b">as<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>4<span class="blank"> </span>horas<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank"> </span>e<span class="blank _c"></span>st<span class="blank _c"></span>imulac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls2f ws49">on)<span class="blank _2"> </span>se<span class="blank _4"> </span>pro<span class="blank"> </span>duce<span class="blank _4"> </span>un<span class="blank _4"> </span>i<span class="blank"> </span>ncremento</span></span></div><div class="t m1 x1d h4 yaa ffb fs2 fc0 sc0 lsc ws57">mayor<span class="blank _2"> </span>de<span class="blank _4"> </span>aproxi<span class="blank _3"> </span>ma<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _f"> </span>2<span class="blank"> </span>-<span class="blank"> </span>3<span class="blank _4"> </span>veces<span class="blank _2"> </span>(<span class="blank"> </span>Ji<span class="blank"> </span>m´<span class="blank _6"></span><span class="lsf ws58">en<span class="blank"> </span>ez,<span class="blank _4"> </span>B.<span class="blank _3"> </span>,<span class="blank _2"> </span>del<span class="blank _4"> </span>Peso,<span class="blank _4"> </span>L.,<span class="blank _4"> </span>Mo<span class="blank"> </span>nta<span class="blank"> </span>ner,<span class="blank _4"> </span>S.<span class="blank"> </span>,<span class="blank _4"> </span>Esteve,<span class="blank _4"> </span>P<span class="blank _1"></span>.<span class="blank _2"> </span>y<span class="blank _4"> </span>La<span class="blank"> </span>ca<span class="blank"> </span>l<span class="blank"> </span>,<span class="blank _2"> </span>J.<span class="blank _3"> </span>C.</span></div><div class="t m1 x1d h4 yab ffb fs2 fc0 sc0 ls10 ws92">1995:<span class="blank _13"> </span>J.<span class="blank"> </span>Ce<span class="blank _c"></span>ll.<span class="blank _16"> </span>Bioc<span class="blank _c"></span>hem.<span class="blank _14"> </span>57:<span class="blank _14"> </span>141-149).<span class="blank _14"> </span>En<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _5"></span>elulas<span class="blank"> </span>trans<span class="blank _1c"></span>f<span class="blank _3"> </span>or<span class="blank _c"></span>madas<span class="blank _2"> </span>p<span class="blank _3"> </span>or<span class="blank"> </span>dife<span class="blank _c"></span>ren<span class="blank _1c"></span>tes<span class="blank"> </span>on<span class="blank _c"></span>coge<span class="blank _c"></span>nes<span class="blank _c"></span>,<span class="blank _8"> </span>tambi<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsf ws93">en<span class="blank"> </span>se</span></div><div class="t m1 x1d h4 yac ffb fs2 fc0 sc0 lsf ws58">apreci<span class="blank _3"> </span>a<span class="blank _f"> </span>q<span class="blank"> </span>u<span class="blank"> </span>e<span class="blank _f"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>n<span class="blank"> </span>i<span class="blank"> </span>vel<span class="blank"> </span>es<span class="blank _f"> </span>de<span class="blank _f"> </span>PC<span class="blank"> </span>h<span class="blank"> </span>o<span class="blank _2"> </span>est´<span class="blank _5"></span>an<span class="blank _2"> </span>i<span class="blank"> </span>ncrem<span class="blank"> </span>enta<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>de<span class="blank _f"> </span>fo<span class="blank"> </span>r<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank _f"> </span>con<span class="blank"> </span>sti<span class="blank _3"> </span>tut<span class="blank"> </span>i<span class="blank"> </span>va.<span class="blank _8"> </span>La<span class="blank _2"> </span>pro<span class="blank"> </span>d<span class="blank"> </span>u<span class="blank"> </span>cci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls2d ws3d">on<span class="blank"> </span>de<span class="blank _2"> </span>PCho<span class="blank"> </span>tras</span></div><div class="t m1 x1d h4 yad ffb fs2 fc0 sc0 ls1b ws94">la<span class="blank"> </span>es<span class="blank _1c"></span>timulac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls8 ws95">on<span class="blank"> </span>mitog<span class="blank _1c"></span>´<span class="blank _6"></span>en<span class="blank _c"></span>ica<span class="blank"> </span>o<span class="blank _2"> </span>tr<span class="blank _c"></span>ansfor<span class="blank _c"></span>maci´<span class="blank _1b"></span><span class="ls14 ws40">on<span class="blank _f"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _2"> </span>oncogenes<span class="blank _f"> </span>es<span class="blank _2"> </span>debida<span class="blank _2"> </span>a<span class="blank _f"> </span>la<span class="blank _f"> </span>activi<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _f"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _f"> </span>q<span class="blank"> </span>ui<span class="blank"> </span>nasa,<span class="blank _f"> </span>pues</span></span></div><div class="t m1 x1d h4 yae ffb fs2 fc0 sc0 ls1c ws96">se<span class="blank"> </span>c<span class="blank _c"></span>ons<span class="blank _c"></span>igue<span class="blank"> </span>su<span class="blank"> </span>total<span class="blank"> </span>d<span class="blank _c"></span>es<span class="blank _c"></span>aparic<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls8 ws82">on<span class="blank"> </span>med<span class="blank _c"></span>iant<span class="blank _c"></span>e<span class="blank"> </span>la<span class="blank"> </span>acci´<span class="blank _1b"></span><span class="ls9 ws5b">on<span class="blank _8"> </span>de<span class="blank _8"> </span>un<span class="blank _9"> </span>inhibidor<span class="blank _8"> </span>de<span class="blank _8"> </span>esta<span class="blank _9"> </span>e<span class="blank _c"></span>nzima,<span class="blank _7"> </span>el<span class="blank _4"> </span>hemicol<span class="blank"> </span>i<span class="blank"> </span>ni<span class="blank"> </span>o-3</span></span></div><div class="t m1 x1d h4 yaf ffb fs2 fc0 sc0 ls2d ws8b">(HC-3),<span class="blank"> </span>an´<span class="blank _5"></span><span class="ls10 ws97">alogo<span class="blank"> </span>e<span class="blank _c"></span>str<span class="blank _1c"></span>uctur<span class="blank _c"></span>al<span class="blank _8"> </span>de<span class="blank"> </span>la<span class="blank"> </span>colin<span class="blank _c"></span>a<span class="blank"> </span>(Carn<span class="blank _c"></span>ero,<span class="blank"> </span>A.,<span class="blank"> </span>Cuadr<span class="blank _c"></span>ado,<span class="blank"> </span>A.,<span class="blank"> </span>de<span class="blank _c"></span>l<span class="blank"> </span>P<span class="blank _1c"></span>eso,<span class="blank _9"> </span>L.<span class="blank _2"> </span>y<span class="blank"> </span>Lacal,<span class="blank"> </span>J.C.<span class="blank"> </span>1994.</span></div><div class="t m1 x1d h4 yb0 ffb fs2 fc0 sc0 ls10 ws56">Onc<span class="blank _1c"></span>ogene<span class="blank _2"> </span>9:<span class="blank _9"> </span>1387-1395);<span class="blank"> </span>J<span class="blank _c"></span>im´<span class="blank _5"></span><span class="ls1e ws74">e<span class="blank _c"></span>nez<span class="blank _c"></span>,<span class="blank"> </span>B.,<span class="blank"> </span>de<span class="blank _1c"></span>l<span class="blank _4"> </span>P<span class="blank _1c"></span>eso,<span class="blank"> </span>L.,<span class="blank"> </span>M<span class="blank _c"></span>on<span class="blank _c"></span>tane<span class="blank _c"></span>r,<span class="blank"> </span>S.,<span class="blank _f"> </span>E<span class="blank _c"></span>ste<span class="blank _c"></span>v<span class="blank _c"></span>e,<span class="blank _2"> </span>P<span class="blank _1c"></span>.<span class="blank _f"> </span>y<span class="blank"> </span>Lacal,<span class="blank"> </span>J<span class="blank _1c"></span>.<span class="blank _3"> </span>C.<span class="blank _f"> </span>1995:<span class="blank _8"> </span>J.<span class="blank"> </span>Cell.</span></div><div class="t m1 x1d h4 yb1 ffb fs2 fc0 sc0 ls1e ws1b">Bioc<span class="blank _c"></span>hem.<span class="blank _7"> </span>57:<span class="blank _13"> </span>141-149;<span class="blank _f"> </span>Cuadr<span class="blank _c"></span>ado,<span class="blank"> </span>A.,<span class="blank"> </span>Car<span class="blank _c"></span>ner<span class="blank _c"></span>o,<span class="blank _4"> </span>A.,<span class="blank"> </span>Dol\ufb01,<span class="blank _f"> </span>F.,<span class="blank"> </span>Jim´<span class="blank _1b"></span><span class="lse ws68">en<span class="blank _c"></span>ez,<span class="blank"> </span>B.<span class="blank"> </span>y<span class="blank"> </span>L<span class="blank _c"></span>acal<span class="blank"> </span>J.C.<span class="blank"> </span>1993.<span class="blank _7"> </span>Onc<span class="blank _c"></span>ogene</span></div><div class="t m1 x1d h4 yb2 ffb fs2 fc0 sc0 ls8 ws98">8:<span class="blank _14"> </span>2959-2968).<span class="blank _17"> </span>El<span class="blank"> </span>inhib<span class="blank _c"></span>idor<span class="blank"> </span>de<span class="blank _2"> </span>colina<span class="blank"> </span>qu<span class="blank _c"></span>inasa<span class="blank"> </span>n<span class="blank _c"></span>o<span class="blank"> </span>solo<span class="blank"> </span>bloque<span class="blank _c"></span>a<span class="blank"> </span>totalme<span class="blank _1c"></span>nte<span class="blank _2"> </span>la<span class="blank"> </span>producc<span class="blank _1c"></span>i<span class="blank _3"> </span>´<span class="blank _1b"></span>on<span class="blank"> </span>de<span class="blank"> </span>fosfor<span class="blank _c"></span>ilco-</div><div class="t m1 x1d h4 yb3 ffb fs2 fc0 sc0 ls2d ws39">li<span class="blank"> </span>na<span class="blank _f"> </span>inducida<span class="blank _2"> </span>por<span class="blank _2"> </span>factores<span class="blank _f"> </span>de<span class="blank _2"> </span>cre<span class="blank _c"></span>cimi<span class="blank"> </span>ento<span class="blank _2"> </span>y<span class="blank _f"> </span>suero<span class="blank _2"> </span>o<span class="blank _f"> </span>c´<span class="blank _5"></span><span class="ls10 ws5b">elulas<span class="blank _f"> </span>tran<span class="blank _c"></span>sformad<span class="blank _c"></span>as<span class="blank _f"> </span>por<span class="blank _f"> </span>oncogene<span class="blank _1c"></span>s,<span class="blank _2"> </span>sino<span class="blank _12"> </span>que<span class="blank _f"> </span>i<span class="blank"> </span>nhibe</span></div><div class="t m1 x1d h4 yb4 ffb fs2 fc0 sc0 ls1a ws99">dr´<span class="blank _5"></span><span class="ls1c ws9a">as<span class="blank _c"></span>ticame<span class="blank _1c"></span>nt<span class="blank _c"></span>e<span class="blank _f"> </span>la<span class="blank"> </span>prolife<span class="blank _c"></span>rac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 ws3b">on<span class="blank"> </span>celular<span class="blank _c"></span>,<span class="blank"> </span>tant<span class="blank _c"></span>o<span class="blank"> </span>en<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls2f ws16">elul<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>norma<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _f"> </span>como<span class="blank _2"> </span>en<span class="blank _12"> </span>tra<span class="blank"> </span>nsfo<span class="blank"> </span>rm<span class="blank"> </span>ada<span class="blank"> </span>s.<span class="blank _9"> </span>Esta<span class="blank _f"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10">on</span></span></span></span></div><div class="t m1 x1d h4 yb5 ffb fs2 fc0 sc0 ls31 ws9b">se<span class="blank"> </span>revi<span class="blank _3"> </span>erte<span class="blank"> </span>cu<span class="blank _3"> </span>ando<span class="blank"> </span>se<span class="blank"> </span>a<span class="blank _3"> </span>\u02dc<span class="blank _1b"></span><span class="ls1c ws9c">nade<span class="blank _4"> </span>fosforilc<span class="blank _1c"></span>olina<span class="blank"> </span>a<span class="blank _4"> </span>las<span class="blank _4"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsc ws48">el<span class="blank"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>o<span class="blank _9"> </span>medi<span class="blank"> </span>a<span class="blank"> </span>nte<span class="blank _8"> </span>la<span class="blank _9"> </span>adi<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws8c">on<span class="blank"> </span>de<span class="blank _8"> </span>sue<span class="blank _1c"></span>ro,<span class="blank _9"> </span>refor<span class="blank _c"></span>z´<span class="blank _1b"></span><span class="ls14 ws8b">andose<span class="blank"> </span>el</span></span></span></span></div><div class="t m1 x1d h4 yb6 ffb fs2 fc0 sc0 ls14 ws40">concepto<span class="blank _4"> </span>de<span class="blank _2"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls10 ws5b">on<span class="blank _2"> </span>espec<span class="blank _d"></span>´<span class="blank _b"></span><span class="lsb ws27">\u0131\ufb01ca<span class="blank _4"> </span>a<span class="blank"> </span>tra<span class="blank _1c"></span>v´<span class="blank _1b"></span><span class="ls2d ws39">es<span class="blank _4"> </span>de<span class="blank _4"> </span>la<span class="blank _4"> </span>enzima<span class="blank _4"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _4"> </span>quinasa<span class="blank _4"> </span>(Carnero,<span class="blank _8"> </span>A.<span class="blank"> </span>,<span class="blank _4"> </span>Cuadrado,<span class="blank _8"> </span>A.,<span class="blank _4"> </span>del</span></span></span></div><div class="t m1 x1d h4 yb7 ffb fs2 fc0 sc0 ls10 ws2b">P<span class="blank _c"></span>es<span class="blank _c"></span>o,<span class="blank"> </span>L.<span class="blank"> </span>y<span class="blank"> </span>Lac<span class="blank _c"></span>al,<span class="blank"> </span>J.C.<span class="blank _12"> </span>1994.<span class="blank _8"> </span>Onc<span class="blank _c"></span>ogene<span class="blank"> </span>9:<span class="blank _8"> </span>1387-1395);<span class="blank _0"> </span>Jim´<span class="blank _5"></span><span class="lsf ws9d">enez,<span class="blank _2"> </span>B.<span class="blank _3"> </span>,<span class="blank"> </span>del<span class="blank"> </span>Peso,<span class="blank"> </span>L<span class="blank _3"> </span>.,<span class="blank"> </span>Mo<span class="blank _3"> </span>n<span class="blank _c"></span>ta<span class="blank _3"> </span>ner,<span class="blank"> </span>S.<span class="blank _3"> </span>,<span class="blank"> </span>Esteve,<span class="blank"> </span>P<span class="blank _1"></span>.</span></div><div class="t m1 x1d h4 yb8 ffb fs2 fc0 sc0 ls1e ws74">y<span class="blank"> </span>Lac<span class="blank _c"></span>al,<span class="blank"> </span>J.C.<span class="blank"> </span>1995:<span class="blank _9"> </span>J.<span class="blank"> </span>Cell.<span class="blank _9"> </span>Bio<span class="blank _3"> </span>c<span class="blank _1c"></span>hem.<span class="blank _7"> </span>57:<span class="blank _9"> </span>141-149;<span class="blank"> </span>Cuadr<span class="blank _c"></span>ado,<span class="blank"> </span>A.,<span class="blank"> </span>Carne<span class="blank _c"></span>ro,<span class="blank"> </span>A.,<span class="blank"> </span>Dol\ufb01,<span class="blank"> </span>F.,<span class="blank"> </span>Jim<span class="blank _1c"></span>´<span class="blank _5"></span><span class="lsc ws38">enez,<span class="blank _4"> </span>B.<span class="blank _4"> </span>y</span></div><div class="t m1 x1d h4 yb9 ffb fs2 fc0 sc0 ls10 ws2b">Lacal<span class="blank"> </span>J<span class="blank _c"></span>.C.<span class="blank"> </span>1993.<span class="blank _4"> </span>Oncoge<span class="blank _c"></span>ne<span class="blank"> </span>8:<span class="blank _9"> </span>2959-2968).</div><div class="t m1 x14 h4 yba ffb fs2 fc0 sc0 ls31 ws7f">Da<span class="blank"> </span>da<span class="blank _0"> </span>l<span class="blank"> </span>a<span class="blank _0"> </span>im<span class="blank"> </span>p<span class="blank _3"> </span>ort<span class="blank"> </span>a<span class="blank"> </span>nci<span class="blank"> </span>a<span class="blank _0"> </span>de<span class="blank _0"> </span>l<span class="blank"> </span>a<span class="blank _0"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _0"> </span>qu<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank"> </span>sa<span class="blank _12"> </span>en<span class="blank _0"> </span>el<span class="blank _12"> </span>sist<span class="blank"> </span>ema<span class="blank _12"> </span>de<span class="blank _0"> </span>tra<span class="blank"> </span>n<span class="blank"> </span>sducci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws5d">on<span class="blank _12"> </span>de<span class="blank"> </span>se\u02dc<span class="blank _11"></span><span class="ls1c ws9e">nales<span class="blank"> </span>mitog<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls8 ws9f">enic<span class="blank _c"></span>as,<span class="blank"> </span>tam<span class="blank _1c"></span>bi´<span class="blank _5"></span><span class="lsc">en</span></span></span></span></div><div class="t m1 x1d h4 ybb ffb fs2 fc0 sc0 ls14 ws40">se<span class="blank _4"> </span>ha<span class="blank _4"> </span>estudiado<span class="blank _8"> </span>el<span class="blank _4"> </span>p<span class="blank"> </span>o<span class="blank"> </span>sibl<span class="blank"> </span>e<span class="blank _8"> </span>pap<span class="blank"> </span>el<span class="blank _8"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>PCho,<span class="blank _8"> </span>pro<span class="blank _3"> </span>ducto<span class="blank _8"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _4"> </span>qui<span class="blank"> </span>nasa,<span class="blank _8"> </span>como<span class="blank _8"> </span>segundo<span class="blank _4"> </span>m<span class="blank"> </span>ensa<span class="blank _3"> </span>jero.</div><div class="t m1 x1d h4 ybc ffb fs2 fc0 sc0 ls31 ws46">Los<span class="blank _2"> </span>resul<span class="blank"> </span>t<span class="blank"> </span>a<span class="blank"> </span>do<span class="blank"> </span>s<span class="blank _4"> </span>demuestran<span class="blank _4"> </span>cl<span class="blank _3"> </span>ara<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _2"> </span>qu<span class="blank"> </span>e<span class="blank _2"> </span>l<span class="blank _3"> </span>a<span class="blank _f"> </span>PC<span class="blank"> </span>ho<span class="blank _4"> </span>es<span class="blank _2"> </span>necesa<span class="blank"> </span>ri<span class="blank"> </span>a<span class="blank _8"> </span>pa<span class="blank"> </span>ra<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>a<span class="blank"> </span>cti<span class="blank"> </span>v<span class="blank"> </span>i<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank _2"> </span>m<span class="blank"> </span>i<span class="blank"> </span>to<span class="blank"> </span>g´<span class="blank _6"></span><span class="lsc ws48">eni<span class="blank"> </span>ca<span class="blank _2"> </span>en<span class="blank _2"> </span>c´<span class="blank _5"></span>el<span class="blank"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>s</span></div><div class="t m1 x1d h4 ybd ffb fs2 fc0 sc0 ls2d ws39">NIH<span class="blank _f"> </span>3<span class="blank"> </span>T3<span class="blank _4"> </span>(Jim´<span class="blank _5"></span><span class="ls1e ws74">ene<span class="blank _c"></span>z,<span class="blank"> </span>B.,<span class="blank"> </span>de<span class="blank _c"></span>l<span class="blank"> </span>Pe<span class="blank _c"></span>so,<span class="blank"> </span>L.,<span class="blank"> </span>Mon<span class="blank _1c"></span>taner,<span class="blank"> </span>S.,<span class="blank"> </span>Es<span class="blank _1c"></span>tev<span class="blank _c"></span>e,<span class="blank"> </span>P<span class="blank _1"></span>.<span class="blank"> </span>y<span class="blank _2"> </span>Lacal,<span class="blank"> </span>J.C.<span class="blank"> </span>1995:<span class="blank _8"> </span>J.<span class="blank"> </span>Cell.<span class="blank _9"> </span>Bio<span class="blank _3"> </span>c<span class="blank _1c"></span>hem.<span class="blank _9"> </span>57:</span></div><div class="t m1 x1d h4 ybe ffb fs2 fc0 sc0 ls1e ws74">141-149).<span class="blank _4"> </span>En<span class="blank"> </span>pre<span class="blank _c"></span>se<span class="blank _c"></span>ncia<span class="blank"> </span>del<span class="blank"> </span>inhibid<span class="blank _c"></span>or<span class="blank _f"> </span>HC-3,<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>cr<span class="blank _c"></span>ec<span class="blank _c"></span>imien<span class="blank _1c"></span>to<span class="blank"> </span>celular<span class="blank _f"> </span>es<span class="blank _c"></span>t´<span class="blank _1b"></span><span class="ls39 wsa0">ad<span class="blank _a"></span>r<span class="blank _e"></span>´<span class="blank _21"></span><span class="ls14 ws40">asticamente<span class="blank _f"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>do<span class="blank _2"> </span>en<span class="blank _2"> </span>c<span class="blank _1c"></span>´<span class="blank _6"></span><span class="lsc ws48">elu<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s</span></span></span></div><div class="t m1 x1d h4 ybf ffb fs2 fc0 sc0 lsf ws58">esti<span class="blank"> </span>mul<span class="blank _3"> </span>ada<span class="blank"> </span>s<span class="blank _2"> </span>p<span class="blank _3"> </span>or<span class="blank _4"> </span>f<span class="blank"> </span>a<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _4"> </span>de<span class="blank _4"> </span>creci<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank _3"> </span>ento<span class="blank _4"> </span>com<span class="blank"> </span>o<span class="blank _4"> </span>PDG<span class="blank _3"> </span>F<span class="blank _2"> </span>o<span class="blank _4"> </span>FGF,<span class="blank _4"> </span>o<span class="blank _2"> </span>en<span class="blank _4"> </span>c´<span class="blank _5"></span><span class="ls10 ws5b">elulas<span class="blank _2"> </span>tran<span class="blank _c"></span>sformad<span class="blank _c"></span>as<span class="blank _2"> </span>p<span class="blank"> </span>or<span class="blank _2"> </span>oncoge<span class="blank _c"></span>nes</span></div><div class="t m1 x1d h18 yc0 ffb fs2 fc0 sc0 ls31 ws46">com<span class="blank"> </span>o<span class="blank _9"> </span>ras<span class="blank _7"> </span><span class="ls3a wsa1 v0">os<span class="blank _6"></span>i<span class="blank _b"></span>s<span class="blank _b"></span><span class="ls3b wsa2">.L<span class="blank _22"></span>a<span class="blank _e"></span>a<span class="blank _22"></span>d<span class="blank _22"></span>i<span class="blank _1e"></span>c<span class="blank _1d"></span>i<span class="blank _1e"></span>´<span class="blank _23"></span><span class="ls8 wsa3">on<span class="blank _8"> </span>de<span class="blank"> </span>ins<span class="blank _c"></span>ulina,<span class="blank"> </span>s<span class="blank _c"></span>in<span class="blank"> </span>e<span class="blank _c"></span>mbar<span class="blank _1c"></span>go,<span class="blank"> </span>revie<span class="blank _c"></span>rte<span class="blank"> </span>es<span class="blank _c"></span>te<span class="blank"> </span>efe<span class="blank _1c"></span>cto<span class="blank"> </span>(Jim<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsf ws28">enez,<span class="blank _13"> </span>B.<span class="blank"> </span>,<span class="blank _7"> </span>del<span class="blank _7"> </span>Peso,<span class="blank _7"> </span>L.<span class="blank"> </span>,</span></span></span></span></div><div class="t m1 x1d h4 yc1 ffb fs2 fc0 sc0 ls10 ws2b">Mon<span class="blank _1c"></span>taner,<span class="blank"> </span>S.,<span class="blank"> </span>Es<span class="blank _c"></span>tev<span class="blank _1c"></span>e,<span class="blank _4"> </span>P<span class="blank _1"></span>.<span class="blank"> </span>y<span class="blank"> </span>Lacal,<span class="blank"> </span>J.C.<span class="blank"> </span>1995:<span class="blank _9"> </span>J<span class="blank _c"></span>.<span class="blank _2"> </span>Cell.<span class="blank _8"> </span>Bio<span class="blank _3"> </span>c<span class="blank _1c"></span>hem.<span class="blank _9"> </span>57:<span class="blank _8"> </span>141-149;<span class="blank"> </span>Cuadrad<span class="blank _c"></span>o,<span class="blank"> </span>A.,<span class="blank"> </span>Carner<span class="blank _c"></span>o,<span class="blank _2"> </span>A.,</div><div class="t m1 x1d h4 yc2 ffb fs2 fc0 sc0 ls1b wsa4">Dol\ufb01,<span class="blank"> </span>F.,<span class="blank"> </span>Jim<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls10 ws56">enez<span class="blank _1c"></span>,<span class="blank _2"> </span>B<span class="blank _c"></span>.<span class="blank"> </span>y<span class="blank"> </span>Lacal<span class="blank"> </span>J<span class="blank _1c"></span>.<span class="blank _3"> </span>C.<span class="blank"> </span>1993.<span class="blank _2"> </span>Oncoge<span class="blank _c"></span>ne<span class="blank"> </span>8:<span class="blank _8"> </span>2959-2968).<span class="blank _2"> </span>Asimismo,<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>pre<span class="blank _1c"></span>senc<span class="blank _c"></span>ia<span class="blank _2"> </span>de<span class="blank"> </span>s<span class="blank _c"></span>uer<span class="blank _c"></span>o<span class="blank"> </span>no<span class="blank _f"> </span>se</span></div><div class="t m1 x1d h4 yc3 ffb fs2 fc0 sc0 ls2d ws39">observ<span class="blank _1c"></span>a<span class="blank _2"> </span>el<span class="blank _2"> </span>efec<span class="blank _c"></span>to<span class="blank _2"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>to<span class="blank"> </span>ri<span class="blank"> </span>o<span class="blank _f"> </span>de<span class="blank _f"> </span>HC-3<span class="blank"> </span>.<span class="blank _9"> </span>P<span class="blank _c"></span>or<span class="blank _2"> </span>tan<span class="blank _c"></span>to,<span class="blank _2"> </span>la<span class="blank _2"> </span>inhibi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _f"> </span>de<span class="blank _2"> </span>la<span class="blank _f"> </span>capacida<span class="blank"> </span>d<span class="blank _2"> </span>mito<span class="blank"> </span>g´<span class="blank _5"></span><span class="lsf ws58">eni<span class="blank _3"> </span>ca<span class="blank _f"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>fa<span class="blank"> </span>cto<span class="blank"> </span>res<span class="blank _2"> </span>d<span class="blank"> </span>e</span></span></div><div class="t m1 x1f h4 yc4 ffb fs2 fc0 sc0 ls9">3</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf4" class="pf w0 h0" data-page-no="4"><div class="pc pc4 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x20 yc5 w4 h19" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg4.png"><div class="t m1 x10 he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x0 hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x11 hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x11 hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x11 hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x11 hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x11 hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x11 hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x11 hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x11 hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x11 hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x11 hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x11 hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x14 h4 y51 ffb fs2 fc0 sc0 ls14 ws40">crec<span class="blank _c"></span>imi<span class="blank"> </span>ento<span class="blank _f"> </span>y<span class="blank _f"> </span>oncogenes<span class="blank _f"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _2"> </span>el<span class="blank _f"> </span>inhibi<span class="blank"> </span>do<span class="blank"> </span>r<span class="blank _12"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>coli<span class="blank"> </span>na<span class="blank _f"> </span>quina<span class="blank"> </span>sa,<span class="blank _2"> </span>HC-3,<span class="blank _12"> </span>no<span class="blank _2"> </span>es<span class="blank _f"> </span>debido<span class="blank _f"> </span>a<span class="blank _f"> </span>un<span class="blank _f"> </span>pro<span class="blank _3"> </span>ceso<span class="blank _f"> </span>de<span class="blank _f"> </span>toxici-</div><div class="t m1 x14 h4 yc6 ffb fs2 fc0 sc0 lsc ws38">da<span class="blank"> </span>d<span class="blank _2"> </span>cel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank _3"> </span>ar<span class="blank _4"> </span>inesp<span class="blank _3"> </span>ec<span class="blank _1"></span>´<span class="blank _a"></span><span class="lsb ws9d">\u0131\ufb01c<span class="blank _c"></span>a,<span class="blank _4"> </span>s<span class="blank _c"></span>ino<span class="blank _f"> </span>al<span class="blank"> </span>bloque<span class="blank _1c"></span>o<span class="blank"> </span>sele<span class="blank _1c"></span>ctiv<span class="blank _1c"></span>o<span class="blank"> </span>y<span class="blank"> </span>e<span class="blank _1c"></span>spec<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls2d ws39">\u0131<span class="blank"> </span>\ufb01co<span class="blank _8"> </span>de<span class="blank _2"> </span>la<span class="blank"> </span>s<span class="blank _2"> </span>rutas<span class="blank _2"> </span>i<span class="blank"> </span>ntracelulares<span class="blank _2"> </span>de<span class="blank _2"> </span>se\u02dc<span class="blank _1b"></span><span class="ls1b ws6c">naliz<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls10 ws72">on.</span></span></span></span></div><div class="t m1 x14 h4 yc7 ffb fs2 fc0 sc0 lsf ws28">Este<span class="blank _4"> </span>ef<span class="blank"> </span>ect<span class="blank"> </span>o<span class="blank _8"> </span>de<span class="blank _4"> </span>i<span class="blank"> </span>nh<span class="blank"> </span>i<span class="blank"> </span>bi<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1c wsa5">on<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank _4"> </span>prolife<span class="blank _1c"></span>raci´<span class="blank _1b"></span><span class="lsf ws28">on<span class="blank _4"> </span>celul<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _4"> </span>se<span class="blank _8"> </span>revi<span class="blank"> </span>erte<span class="blank _8"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _4"> </span>ad<span class="blank"> </span>i<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls2d ws4b">on<span class="blank _4"> </span>de<span class="blank _4"> </span>PCho,<span class="blank _4"> </span>remarc´<span class="blank _5"></span><span class="ls14 ws7b">andose<span class="blank"> </span>con</span></span></span></span></div><div class="t m1 x14 h4 yc8 ffb fs2 fc0 sc0 ls1b ws94">ello<span class="blank"> </span>la<span class="blank"> </span>e<span class="blank _1c"></span>spec<span class="blank _c"></span>i\ufb01cid<span class="blank _c"></span>ad<span class="blank _2"> </span>de<span class="blank _1c"></span>l<span class="blank _2"> </span>sis<span class="blank _c"></span>te<span class="blank _c"></span>ma.</div><div class="t m1 x13 h4 yc9 ffb fs2 fc0 sc0 ls2f ws16">En<span class="blank _4"> </span>resumen,<span class="blank _9"> </span>to<span class="blank _3"> </span>dos<span class="blank _9"> </span>e<span class="blank _c"></span>stos<span class="blank _8"> </span>resulta<span class="blank"> </span>do<span class="blank"> </span>s<span class="blank _8"> </span>previ<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _8"> </span>demuestra<span class="blank _8"> </span>una<span class="blank _8"> </span>al<span class="blank"> </span>ta<span class="blank _8"> </span>especi\ufb01ci<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _9"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _8"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls1c wsa5">on<span class="blank"> </span>de<span class="blank _4"> </span>la</span></div><div class="t m1 x14 h4 yca ffb fs2 fc0 sc0 ls1c ws3a">prolife<span class="blank _1c"></span>raci´<span class="blank _1b"></span><span class="ls14 ws40">on<span class="blank _12"> </span>celula<span class="blank"> </span>r<span class="blank _2"> </span>po<span class="blank"> </span>r<span class="blank _f"> </span>el<span class="blank _2"> </span>inhibi<span class="blank"> </span>do<span class="blank"> </span>r<span class="blank _f"> </span>de<span class="blank _f"> </span>la<span class="blank _f"> </span>colina<span class="blank _2"> </span>quinasa<span class="blank _f"> </span>HC-3.<span class="blank _8"> </span>La<span class="blank _2"> </span>colina<span class="blank _f"> </span>qui<span class="blank"> </span>na<span class="blank"> </span>sa<span class="blank _f"> </span>es,<span class="blank _2"> </span>po<span class="blank"> </span>r<span class="blank _f"> </span>tanto,<span class="blank _f"> </span>un<span class="blank _f"> </span>paso</span></div><div class="t m1 x14 h4 ycb ffb fs2 fc0 sc0 ls8 ws50">importan<span class="blank _1c"></span>te<span class="blank _f"> </span>en<span class="blank _f"> </span>la<span class="blank _2"> </span>re<span class="blank _1c"></span>gulaci´<span class="blank _1b"></span><span class="ls1c ws73">on<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank _2"> </span>pr<span class="blank _c"></span>olifer<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="lsf ws58">on<span class="blank _f"> </span>cel<span class="blank _3"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _2"> </span>y<span class="blank _1c"></span>,<span class="blank _2"> </span>como<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank"> </span>secuen<span class="blank"> </span>ci<span class="blank"> </span>a<span class="blank"> </span>,<span class="blank _8"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>estructu<span class="blank"> </span>ra<span class="blank"> </span>s<span class="blank _4"> </span>m<span class="blank"> </span>o<span class="blank"> </span>l<span class="blank"> </span>ecul<span class="blank _3"> </span>ares</span></span></div><div class="t m1 x14 h4 ycc ffb fs2 fc0 sc0 lsf ws58">de<span class="blank _2"> </span>HC-3<span class="blank _2"> </span>y<span class="blank _2"> </span>PCho<span class="blank _2"> </span>so<span class="blank"> </span>n<span class="blank _2"> </span>excel<span class="blank _3"> </span>entes<span class="blank _2"> </span>m<span class="blank _3"> </span>o<span class="blank"> </span>d<span class="blank"> </span>el<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>pa<span class="blank"> </span>ra<span class="blank _2"> </span>el<span class="blank _2"> </span>estudi<span class="blank _3"> </span>o<span class="blank _2"> </span>y<span class="blank _2"> </span>desarro<span class="blank"> </span>l<span class="blank"> </span>l<span class="blank _3"> </span>o<span class="blank _2"> </span>de<span class="blank _2"> </span>agentes<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank _2"> </span>a<span class="blank"> </span>cti<span class="blank _3"> </span>vi<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank _f"> </span>a<span class="blank"> </span>nti<span class="blank"> </span>tu<span class="blank"> </span>m<span class="blank"> </span>o<span class="blank"> </span>-</div><div class="t m1 x14 h4 ycd ffb fs2 fc0 sc0 ls30 wsa6">ral<span class="blank"> </span>.<span class="blank _8"> </span>El<span class="blank _f"> </span>di<span class="blank"> </span>se<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="lsf ws28">n<span class="blank"> </span>o<span class="blank _2"> </span>de<span class="blank _f"> </span>d<span class="blank"> </span>eri<span class="blank"> </span>v<span class="blank _c"></span>ad<span class="blank"> </span>os<span class="blank _2"> </span>que<span class="blank _f"> </span>af<span class="blank"> </span>ect<span class="blank"> </span>en<span class="blank _2"> </span>di<span class="blank"> </span>recta<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _f"> </span>a<span class="blank _2"> </span>la<span class="blank _f"> </span>a<span class="blank"> </span>cti<span class="blank"> </span>v<span class="blank"> </span>i<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _f"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _f"> </span>q<span class="blank"> </span>ui<span class="blank"> </span>na<span class="blank"> </span>sa<span class="blank _f"> </span>o<span class="blank _2"> </span>a<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>enzi<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank _f"> </span>acti<span class="blank"> </span>vada</span></div><div class="t m1 x14 h4 yce ffb fs2 fc0 sc0 ls8 ws45">por<span class="blank"> </span>fosforilc<span class="blank _c"></span>olina,<span class="blank"> </span>de<span class="blank"> </span>forma<span class="blank"> </span>individ<span class="blank _c"></span>ual<span class="blank"> </span>o<span class="blank"> </span>com<span class="blank _c"></span>binada,<span class="blank"> </span>p<span class="blank _c"></span>ue<span class="blank _c"></span>den<span class="blank _4"> </span>per<span class="blank _c"></span>mitir<span class="blank"> </span>desar<span class="blank _c"></span>rollar<span class="blank"> </span>te<span class="blank _1c"></span>rapias<span class="blank"> </span>antit<span class="blank _c"></span>umorale<span class="blank _1c"></span>s</div><div class="t m1 x14 h4 ycf ffb fs2 fc0 sc0 lsc ws57">efect<span class="blank"> </span>i<span class="blank"> </span>vas.</div><div class="t m1 x14 h4 yd0 ffb fs2 fc0 sc0 ls1c wsa7">3.1.-<span class="blank"> </span><span class="ffe ls30 wsa8">Conc<span class="blank _c"></span>epto<span class="blank _2"> </span>y<span class="blank _4"> </span>ensayos<span class="blank _4"> </span>metodol´<span class="blank _1b"></span><span class="ls6 wsa9">ogic<span class="blank _1c"></span>os<span class="blank"> </span>en<span class="blank"> </span>los<span class="blank"> </span>que<span class="blank"> </span>se<span class="blank"> </span>b<span class="blank _1c"></span>asa<span class="blank _4"> </span>la<span class="blank"> </span>so<span class="blank _c"></span>lici<span class="blank _3"> </span>tud<span class="blank _f"> </span>de<span class="blank"> </span>p<span class="blank _1c"></span>atente</span></span></div><div class="t m1 x13 h4 yd1 ffb fs2 fc0 sc0 ls1c ws9f">Los<span class="blank"> </span>e<span class="blank _c"></span>nsa<span class="blank _1c"></span>yos<span class="blank"> </span>que<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank _12"> </span>utiliz<span class="blank _1c"></span>ar´<span class="blank _5"></span><span class="ls8 wsaa">an<span class="blank"> </span>par<span class="blank _c"></span>a<span class="blank _0"> </span>el<span class="blank _12"> </span>cr<span class="blank _c"></span>iba<span class="blank _3"> </span>je<span class="blank _12"> </span>de<span class="blank"> </span>compu<span class="blank _c"></span>es<span class="blank _c"></span>tos<span class="blank _0"> </span>con<span class="blank _12"> </span>posible<span class="blank"> </span>activida<span class="blank _c"></span>d<span class="blank"> </span>an<span class="blank _c"></span>titumor<span class="blank _1c"></span>al<span class="blank"> </span>se<span class="blank _12"> </span>bas<span class="blank _c"></span>an</span></div><div class="t m1 x14 h4 yd2 ffb fs2 fc0 sc0 ls2d ws39">en<span class="blank _2"> </span>la<span class="blank _4"> </span>capacidad<span class="blank _2"> </span>de<span class="blank _4"> </span>los<span class="blank _2"> </span>mismo<span class="blank"> </span>s<span class="blank _2"> </span>pa<span class="blank"> </span>ra<span class="blank _4"> </span>inhibi<span class="blank"> </span>r<span class="blank _2"> </span>la<span class="blank _2"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _5"></span><span class="ls8 ws4c">on<span class="blank _2"> </span>de<span class="blank _2"> </span>fosfor<span class="blank _c"></span>ilcolin<span class="blank _c"></span>a<span class="blank"> </span>(P</span></div><div class="t m1 x21 h4 yd3 ffb fs2 fc0 sc0 ls10 ws77">Cho)<span class="blank"> </span>o<span class="blank"> </span>de<span class="blank"> </span>inte<span class="blank _1c"></span>rferir<span class="blank"> </span>con<span class="blank"> </span>la</div><div class="t m1 x14 h4 yd4 ffb fs2 fc0 sc0 ls1b ws6c">utiliz<span class="blank _1c"></span>aci´<span class="blank _1b"></span><span class="ls1c ws88">on<span class="blank _0"> </span>de<span class="blank _12"> </span>es<span class="blank _c"></span>te<span class="blank _f"> </span>met<span class="blank _c"></span>abolito<span class="blank _0"> </span>en<span class="blank _12"> </span>rut<span class="blank _c"></span>as<span class="blank _f"> </span>de<span class="blank _12"> </span>tran<span class="blank _c"></span>smis<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 ws3f">on<span class="blank"> </span>de<span class="blank _f"> </span>se\u02dc<span class="blank _11"></span><span class="ls1c ws61">nales<span class="blank"> </span>mitog<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls2d ws39">eni<span class="blank"> </span>cas,<span class="blank _12"> </span>i<span class="blank"> </span>ndep<span class="blank"> </span>endientes<span class="blank _f"> </span>de<span class="blank _f"> </span>las<span class="blank _12"> </span>ruta<span class="blank"> </span>s</span></span></span></span></div><div class="t m1 x14 h4 yd5 ffb fs2 fc0 sc0 ls14 wsab">de<span class="blank"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1c wsac">\u0131nte<span class="blank _1c"></span>sis<span class="blank _2"> </span>de<span class="blank _12"> </span>fosfat<span class="blank _c"></span>idilcolin<span class="blank _c"></span>a,<span class="blank"> </span>uno<span class="blank _f"> </span>de<span class="blank _f"> </span>los<span class="blank _f"> </span>l<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1b ws7a">\u0131pidos<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _f"> </span>mem<span class="blank _c"></span>br<span class="blank _c"></span>ana<span class="blank"> </span>m´<span class="blank _1b"></span><span class="ls14 wsad">as<span class="blank"> </span>a<span class="blank _3"> </span>bundan<span class="blank _c"></span>te<span class="blank"> </span>en<span class="blank _2"> </span>las<span class="blank"> </span>c´<span class="blank _5"></span><span class="lsf ws28">elu<span class="blank"> </span>l<span class="blank"> </span>as<span class="blank _f"> </span>eu<span class="blank"> </span>ca<span class="blank"> </span>ri<span class="blank"> </span>´<span class="blank _5"></span><span class="ls8 ws62">oticas<span class="blank _1c"></span>.</span></span></span></span></span></div><div class="t m1 x14 h4 yd6 ffb fs2 fc0 sc0 ls31 ws65">El<span class="blank _f"> </span>esq<span class="blank"> </span>u<span class="blank"> </span>em<span class="blank _3"> </span>a<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>s<span class="blank _d"></span>´<span class="blank _e"></span><span class="ls1c ws73">\u0131n<span class="blank _1c"></span>tes<span class="blank _c"></span>is<span class="blank _2"> </span>de<span class="blank"> </span>fos<span class="blank _c"></span>fatidilc<span class="blank _1c"></span>olina<span class="blank _12"> </span>(PC<span class="blank _c"></span>)<span class="blank"> </span>se<span class="blank"> </span>pued<span class="blank _c"></span>e<span class="blank _2"> </span>r<span class="blank _c"></span>es<span class="blank _c"></span>umir<span class="blank"> </span>en<span class="blank"> </span>la<span class="blank"> </span>siguie<span class="blank _1c"></span>nte<span class="blank"> </span>p<span class="blank _c"></span>roce<span class="blank _c"></span>so<span class="blank"> </span>biol´<span class="blank _5"></span><span class="ls8 ws62">ogico<span class="blank _c"></span>:</span></span></div><div class="t m1 x22 h4 yd7 ffb fs2 fc0 sc0 ls3c wsae">12<span class="blank _b"></span>3</div><div class="t m1 x23 h4 yd8 ffb fs2 fc0 sc0 lsb wsaf">co<span class="blank _c"></span>lina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _a"></span>\u2192<span class="blank"> </span><span class="ffb ls1c wsb1">fosforilc<span class="blank _1c"></span>olina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _e"></span>\u2192<span class="blank"> </span><span class="ffb lsb wsb2">CD<span class="blank _c"></span>P-c<span class="blank _1c"></span>olina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _a"></span>\u2192<span class="blank"> </span><span class="ffb ls1c ws3a">fosfatidilc<span class="blank _1c"></span>olina</span></span></span></span></span></span></div><div class="t m1 x24 h1a yd9 ffb fs2 fc0 sc0 ls2f ws44">(P<span class="ls36 wsb3 v0">ch<span class="blank"> </span>o<span class="blank"> </span>)<span class="blank _24"> </span>(<span class="blank"> </span>P<span class="blank"> </span>C<span class="blank"> </span>)</span></div><div class="t m1 x14 h4 yda ffb fs2 fc0 sc0 ls1c ws4f">dond<span class="blank _c"></span>e<span class="blank"> </span>1<span class="blank"> </span>cor<span class="blank _c"></span>re<span class="blank _c"></span>sponde<span class="blank"> </span>a<span class="blank"> </span>la<span class="blank"> </span>colina<span class="blank _f"> </span>qu<span class="blank _c"></span>inas<span class="blank _c"></span>a<span class="blank"> </span>(EC<span class="blank"> </span>2.7.1.32),<span class="blank _0"> </span>2<span class="blank _2"> </span>a<span class="blank"> </span>la<span class="blank"> </span>c<span class="blank _c"></span>itidilil-t<span class="blank _c"></span>rans<span class="blank _1c"></span>feras<span class="blank _c"></span>a<span class="blank"> </span>(<span class="blank _c"></span>EC<span class="blank"> </span>2.7.7.15),<span class="blank _12"> </span>y<span class="blank"> </span>3<span class="blank"> </span>a<span class="blank"> </span>la</div><div class="t m1 x14 h4 ydb ffb fs2 fc0 sc0 ls8 ws4c">colin<span class="blank _c"></span>o-fosfot<span class="blank _c"></span>rans<span class="blank _c"></span>fer<span class="blank _c"></span>asa<span class="blank"> </span>(<span class="blank _c"></span>EC<span class="blank"> </span>2.7.8.2).</div><div class="t m1 x13 h4 ydc ffb fs2 fc0 sc0 ls1c ws4f">La<span class="blank"> </span>ide<span class="blank _1c"></span>a<span class="blank"> </span>original<span class="blank _12"> </span>en<span class="blank"> </span>la<span class="blank"> </span>que<span class="blank _12"> </span>se<span class="blank"> </span>basa<span class="blank"> </span>la<span class="blank"> </span>s<span class="blank _c"></span>olicit<span class="blank _c"></span>ud<span class="blank _f"> </span>de<span class="blank"> </span>la<span class="blank _12"> </span>paten<span class="blank _1c"></span>te,<span class="blank"> </span>implica<span class="blank _0"> </span>que<span class="blank"> </span>la<span class="blank"> </span>P<span class="blank _c"></span>Cho<span class="blank"> </span>es<span class="blank"> </span>u<span class="blank _c"></span>tiliz<span class="blank _c"></span>ada<span class="blank _f"> </span>por<span class="blank"> </span>las</div><div class="t m1 x14 h4 ydd ffb fs2 fc0 sc0 ls36 ws6f">c´<span class="blank _6"></span><span class="ls2f ws16">el<span class="blank"> </span>ul<span class="blank"> </span>as<span class="blank _4"> </span>para<span class="blank _4"> </span>una<span class="blank _4"> </span>ruta<span class="blank _4"> </span>de<span class="blank _2"> </span>tra<span class="blank"> </span>nsmi<span class="blank"> </span>si<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 wsb4">on<span class="blank"> </span>de<span class="blank _4"> </span>se\u02dc<span class="blank _1b"></span><span class="ls1c ws9c">n<span class="blank _c"></span>ales<span class="blank _c"></span>,<span class="blank _4"> </span>alte<span class="blank _1c"></span>rnativ<span class="blank _1"></span>a<span class="blank"> </span>y<span class="blank _4"> </span>difer<span class="blank _c"></span>en<span class="blank _1c"></span>te<span class="blank _4"> </span>a<span class="blank"> </span>la<span class="blank"> </span>de<span class="blank"> </span>s<span class="blank _d"></span>´<span class="blank _b"></span><span class="lsf ws28">\u0131<span class="blank"> </span>ntesi<span class="blank"> </span>s<span class="blank _4"> </span>d<span class="blank"> </span>e<span class="blank _4"> </span>PC,<span class="blank _8"> </span>esenci<span class="blank"> </span>a<span class="blank"> </span>l</span></span></span></span></div><div class="t m1 x14 h4 yde ffb fs2 fc0 sc0 ls16 ws65">para<span class="blank _4"> </span>la<span class="blank _4"> </span>reg<span class="blank"> </span>ul<span class="blank _3"> </span>aci<span class="blank"> </span>´<span class="blank _5"></span><span class="lsf ws28">o<span class="blank"> </span>n<span class="blank _2"> </span>d<span class="blank"> </span>el<span class="blank _4"> </span>creci<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank"> </span>ento<span class="blank _4"> </span>cel<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>ar<span class="blank"> </span>.<span class="blank _16"> </span>Est<span class="blank"> </span>a<span class="blank _4"> </span>hi<span class="blank"> </span>p<span class="blank"> </span>´<span class="blank _5"></span><span class="ls14 ws40">otesis<span class="blank _4"> </span>ha<span class="blank _4"> </span>sido<span class="blank _4"> </span>publicada<span class="blank _2"> </span>(Ji<span class="blank"> </span>m´<span class="blank _5"></span><span class="lsf wsb5">enez,<span class="blank _9"> </span>B.,<span class="blank"> </span>del<span class="blank"> </span>Peso,<span class="blank"> </span>L<span class="blank _3"> </span>.,</span></span></span></div><div class="t m1 x14 h4 ydf ffb fs2 fc0 sc0 ls1e ws61">Mon<span class="blank _1c"></span>taner<span class="blank _c"></span>,<span class="blank _f"> </span>S.,<span class="blank"> </span>Est<span class="blank _c"></span>ev<span class="blank _1c"></span>e,<span class="blank _2"> </span>P<span class="blank _1"></span>.<span class="blank"> </span>y<span class="blank _f"> </span>Lacal,<span class="blank"> </span>J.C.<span class="blank"> </span>1995:<span class="blank _4"> </span>J.<span class="blank _f"> </span>Cell.<span class="blank _8"> </span>Bio<span class="blank _3"> </span>c<span class="blank _1c"></span>hem.<span class="blank _4"> </span>57:<span class="blank _8"> </span>141-149)<span class="blank"> </span>por<span class="blank"> </span>l<span class="blank _3"> </span>os<span class="blank"> </span>in<span class="blank _1c"></span>ve<span class="blank _c"></span>stigad<span class="blank _c"></span>ore<span class="blank _c"></span>s<span class="blank"> </span>solici-</div><div class="t m1 x14 h1b ye0 ffb fs2 fc0 sc0 ls2f ws49">tantes<span class="blank _c"></span>.<span class="blank _8"> </span>Por<span class="blank _12"> </span>´<span class="blank _1b"></span>ulti<span class="blank"> </span>m<span class="blank"> </span>o<span class="blank"> </span>,<span class="blank _12"> </span>hemos<span class="blank _0"> </span>demo<span class="blank"> </span>strado<span class="blank _12"> </span>ta<span class="blank"> </span>mbi´<span class="blank _5"></span><span class="lsc ws38">en<span class="blank _0"> </span>q<span class="blank _3"> </span>ue<span class="blank _12"> </span>l<span class="blank _3"> </span>as<span class="blank _0"> </span>c´<span class="blank _6"></span><span class="ls10 ws5b">elulas<span class="blank _0"> </span>tr<span class="blank _c"></span>ansfor<span class="blank _c"></span>madas<span class="blank _20"> </span>p<span class="blank"> </span>or<span class="blank _12"> </span>oncoge<span class="blank _c"></span>nes<span class="blank _0"> </span>ras<span class="blank _0"> </span><span class="lsc ws38 v0">presenta<span class="blank"> </span>n</span></span></span></div><div class="t m1 x14 h4 ye1 ffb fs2 fc0 sc0 lsb wsad">uno<span class="blank _c"></span>s<span class="blank"> </span>nie<span class="blank _c"></span>v<span class="blank _c"></span>ele<span class="blank _1c"></span>s<span class="blank _2"> </span>ele<span class="blank _c"></span>v<span class="blank _1c"></span>ados<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _2"> </span>P</div><div class="t m1 x25 h4 ye2 ffb fs2 fc0 sc0 ls1b ws2e">Cho<span class="blank"> </span>d<span class="blank _c"></span>eb<span class="blank _c"></span>ido<span class="blank"> </span>a<span class="blank"> </span>la<span class="blank _f"> </span>ac<span class="blank _c"></span>tiv<span class="blank _1"></span>aci´<span class="blank _1b"></span><span class="ls2d ws39">on<span class="blank _2"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>ruta<span class="blank _2"> </span>dependiente<span class="blank _2"> </span>de<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _2"> </span>qui<span class="blank"> </span>na<span class="blank"> </span>sa.<span class="blank _9"> </span>Este</span></div><div class="t m1 x14 h4 ye3 ffb fs2 fc0 sc0 ls8 ws2c">trab<span class="blank _c"></span>a<span class="blank _3"> </span>jo<span class="blank"> </span>ha<span class="blank"> </span>sido<span class="blank"> </span>p<span class="blank _c"></span>ublic<span class="blank _1c"></span>ado<span class="blank"> </span>rec<span class="blank _1c"></span>ien<span class="blank _c"></span>te<span class="blank _c"></span>men<span class="blank _1c"></span>te<span class="blank _2"> </span>(Cuadrad<span class="blank _c"></span>o,<span class="blank"> </span>A.,<span class="blank"> </span>Car<span class="blank _c"></span>ner<span class="blank _c"></span>o,<span class="blank"> </span>A.,<span class="blank"> </span>Dol\ufb01,<span class="blank"> </span>F<span class="blank _c"></span>.,<span class="blank"> </span>Jim<span class="blank _c"></span>´<span class="blank _1b"></span><span class="lsf ws38">en<span class="blank"> </span>ez,<span class="blank _4"> </span>B.<span class="blank _f"> </span>y<span class="blank _2"> </span>La<span class="blank"> </span>ca<span class="blank _3"> </span>l<span class="blank _f"> </span>J.<span class="blank _3"> </span>C.</span></div><div class="t m1 x14 h4 ye4 ffb fs2 fc0 sc0 ls1e wsb6">1993.<span class="blank _4"> </span>On<span class="blank _c"></span>coge<span class="blank _c"></span>ne<span class="blank"> </span>8:<span class="blank _8"> </span>2959-2968).<span class="blank _4"> </span>Bas<span class="blank _c"></span>ado<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>est<span class="blank _c"></span>os<span class="blank"> </span>des<span class="blank _c"></span>cu<span class="blank _c"></span>brimie<span class="blank _c"></span>n<span class="blank _c"></span>tos,<span class="blank"> </span>se<span class="blank"> </span>pu<span class="blank _c"></span>ede<span class="blank"> </span>c<span class="blank _1c"></span>oncluir<span class="blank _12"> </span>que<span class="blank"> </span>exis<span class="blank _c"></span>ten<span class="blank"> </span>al<span class="blank _12"> </span>menos</div><div class="t m1 x14 h4 ye5 ffb fs2 fc0 sc0 ls2d ws39">dos<span class="blank _4"> </span>alternativas<span class="blank _2"> </span>por<span class="blank _4"> </span>las<span class="blank _4"> </span>cuales<span class="blank _4"> </span>se<span class="blank _4"> </span>puede<span class="blank _4"> </span>inhibi<span class="blank"> </span>r<span class="blank _2"> </span>dr´<span class="blank _5"></span><span class="lsc ws57">a<span class="blank"> </span>st<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _8"> </span>y<span class="blank _4"> </span>esp<span class="blank"> </span>ec<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls1b ws18">\u0131\ufb01came<span class="blank _1c"></span>nt<span class="blank _c"></span>e<span class="blank _4"> </span>la<span class="blank"> </span>prolife<span class="blank _c"></span>rac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 wsb4">on<span class="blank"> </span>celular</span></span></span></div><div class="t m1 x14 h4 ye6 ffb fs2 fc0 sc0 ls14 wsb7">de<span class="blank"> </span>l<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls8 ws56">\u0131neas<span class="blank"> </span>tumorale<span class="blank _1c"></span>s<span class="blank"> </span>siguien<span class="blank _c"></span>do<span class="blank _f"> </span>cualquie<span class="blank _c"></span>ra<span class="blank"> </span>de<span class="blank _f"> </span>esta<span class="blank _c"></span>s<span class="blank _2"> </span>es<span class="blank _1c"></span>trate<span class="blank _c"></span>gias:</span></div><div class="t m1 x13 h1c ye7 ffb fs2 fc0 sc0 ls2d ws39">1)<span class="blank _2"> </span>inhibi<span class="blank"> </span>endo<span class="blank _f"> </span>di<span class="blank"> </span>rectamente<span class="blank _2"> </span>la<span class="blank _f"> </span>coli<span class="blank"> </span>na<span class="blank _2"> </span>quinasa,<span class="blank _f"> </span>responsabl<span class="blank"> </span>e<span class="blank _4"> </span>directa<span class="blank _2"> </span>de<span class="blank _f"> </span>la<span class="blank _2"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _1b"></span><span class="ls10 wsb8">on<span class="blank _2"> </span>de<span class="blank _f"> </span>P<span class="ls19 v0">Cho.</span></span></div><div class="t m1 x13 h4 ye8 ffb fs2 fc0 sc0 ls1c ws9c">2)<span class="blank"> </span>blo<span class="blank _3"> </span>qu<span class="blank _c"></span>ean<span class="blank _c"></span>do<span class="blank"> </span>la<span class="blank"> </span>utiliz<span class="blank _1c"></span>aci´<span class="blank _1b"></span>on<span class="blank"> </span>de<span class="blank _4"> </span>la<span class="blank"> </span>P</div><div class="t m1 x10 h4 ye9 ffb fs2 fc0 sc0 lsf ws58">Cho<span class="blank _8"> </span>di<span class="blank"> </span>recta<span class="blank"> </span>m<span class="blank _3"> </span>ente<span class="blank _4"> </span>si<span class="blank"> </span>n<span class="blank _4"> </span>a<span class="blank"> </span>f<span class="blank"> </span>ecta<span class="blank"> </span>r<span class="blank _4"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _4"> </span>ni<span class="blank _3"> </span>veles<span class="blank _4"> </span>no<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _4"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>con<span class="blank"> </span>cen-</div><div class="t m1 x14 h4 yea ffb fs2 fc0 sc0 ls32 ws49">traci´<span class="blank _5"></span><span class="ls10 ws3b">on<span class="blank"> </span>de<span class="blank _2"> </span>P</span></div><div class="t m1 x26 h4 yeb ffb fs2 fc0 sc0 ls19 wsb9">Cho<span class="blank"> </span>citos´<span class="blank _1b"></span><span class="ls8 ws50">olic<span class="blank _c"></span>a,<span class="blank _f"> </span>por<span class="blank _f"> </span>un(as<span class="blank _c"></span>)<span class="blank _2"> </span>en<span class="blank _c"></span>zima(<span class="blank _c"></span>s)<span class="blank _f"> </span>a<span class="blank"> </span>´<span class="blank _1b"></span><span class="ls2f ws16">un<span class="blank _2"> </span>sin<span class="blank _2"> </span>iden<span class="blank _c"></span>ti\ufb01car.</span></span></div><div class="t m1 x14 h4 yec ffb fs2 fc0 sc0 ls1c wsa7">3.2.-<span class="blank"> </span><span class="ffe ls1a wsba">Estrate<span class="blank _1c"></span>gia<span class="blank _2"> </span>de<span class="blank _2"> </span>inhi<span class="blank"> </span>bi<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls32 wsa8">on<span class="blank _2"> </span>de<span class="blank _2"> </span>la<span class="blank _4"> </span>activi<span class="blank"> </span>dad<span class="blank _2"> </span>de<span class="blank _4"> </span>la<span class="blank _2"> </span>c<span class="blank _c"></span>oli<span class="blank"> </span>na<span class="blank _2"> </span>qui<span class="blank"> </span>nasa</span></span></div><div class="t m1 x13 h1d yed ffb fs2 fc0 sc0 ls9 ws5b">La<span class="blank _12"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls2d ws39">on<span class="blank _12"> </span>de<span class="blank _f"> </span>la<span class="blank _12"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _5"></span><span class="ls10 wsbb">on<span class="blank _f"> </span>de<span class="blank _0"> </span>P<span class="blank"> </span><span class="ls14 ws40 v0">Cho<span class="blank _f"> </span>se<span class="blank _f"> </span>puede<span class="blank _12"> </span>conseguir<span class="blank _f"> </span>mediante<span class="blank _12"> </span>la<span class="blank _12"> </span>i<span class="blank"> </span>nhi<span class="blank"> </span>bi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="lsc ws48">o<span class="blank"> </span>n<span class="blank _12"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>enzi<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank _f"> </span>col<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>a</span></span></span></span></div><div class="t m1 x14 h4 y78 ffb fs2 fc0 sc0 lse wsbc">quinas<span class="blank _c"></span>a<span class="blank"> </span>(ChoK)<span class="blank _c"></span>.<span class="blank"> </span>Los<span class="blank"> </span>compu<span class="blank _c"></span>est<span class="blank _c"></span>os<span class="blank _12"> </span>que<span class="blank"> </span>se<span class="blank"> </span>han<span class="blank"> </span>sint<span class="blank _c"></span>etiz<span class="blank _1c"></span>ado<span class="blank _12"> </span>y<span class="blank"> </span>que<span class="blank"> </span>se<span class="blank"> </span>pret<span class="blank _c"></span>end<span class="blank _c"></span>en<span class="blank _f"> </span>pat<span class="blank _c"></span>en<span class="blank _1c"></span>tar,<span class="blank _12"> </span>son<span class="blank"> </span>inhibidore<span class="blank _c"></span>s<span class="blank"> </span>de<span class="blank"> </span>la</div><div class="t m1 x14 h4 yee ffb fs2 fc0 sc0 ls14 ws40">colina<span class="blank _12"> </span>q<span class="blank"> </span>ui<span class="blank"> </span>nasa.<span class="blank _8"> </span>Para<span class="blank _12"> </span>m<span class="blank"> </span>edir<span class="blank _f"> </span>su<span class="blank _f"> </span>actividad<span class="blank _12"> </span>se<span class="blank _f"> </span>han<span class="blank _12"> </span>empl<span class="blank"> </span>eado<span class="blank _f"> </span>tanto<span class="blank _12"> </span>sistemas<span class="blank _f"> </span><span class="ffe ls2d wsbd">ex<span class="blank _f"> </span>vi<span class="blank _3"> </span>vo<span class="blank"> </span><span class="ffb ws49">(en<span class="blank _f"> </span>tubo<span class="blank _f"> </span>d<span class="blank"> </span>e<span class="blank _12"> </span>ensay<span class="blank _c"></span>o,<span class="blank _2"> </span>libre</span></span></div><div class="t m1 x14 h4 yef ffb fs2 fc0 sc0 ls14 ws1c">de<span class="blank"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls1e ws70">elulas)<span class="blank"> </span>c<span class="blank _1c"></span>omo<span class="blank _4"> </span><span class="ffe ls10 wsbe">in<span class="blank _4"> </span>vitr<span class="blank _1c"></span>o<span class="blank"> </span><span class="ffb ls2f ws49">(en<span class="blank _4"> </span>c<span class="blank _1c"></span>´<span class="blank _6"></span>elul<span class="blank"> </span>as<span class="blank _4"> </span>vivas<span class="blank _f"> </span>intactas).<span class="blank _14"> </span>En<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>actualida<span class="blank"> </span>d<span class="blank _4"> </span>se<span class="blank _2"> </span>disp<span class="blank"> </span>o<span class="blank"> </span>nen<span class="blank _4"> </span>de<span class="blank _2"> </span>di<span class="blank"> </span>versos<span class="blank _2"> </span>m´<span class="blank _b"></span><span class="lsc ws38">eto<span class="blank _3"> </span>do<span class="blank _3"> </span>s</span></span></span></span></div><div class="t m1 x14 h4 yf0 ffb fs2 fc0 sc0 ls8 ws87">alte<span class="blank _c"></span>rnat<span class="blank _c"></span>iv<span class="blank _c"></span>os<span class="blank"> </span>y<span class="blank"> </span>\ufb01ables<span class="blank"> </span>p<span class="blank _c"></span>ara<span class="blank _12"> </span>la<span class="blank"> </span>det<span class="blank _c"></span>er<span class="blank _c"></span>minac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls14 ws40">o<span class="blank"> </span>n<span class="blank _f"> </span>de<span class="blank _12"> </span>la<span class="blank _0"> </span>a<span class="blank"> </span>ctivi<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _12"> </span>de<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _12"> </span>quinasa<span class="blank _12"> </span><span class="ffe ls2d wsbf">ex<span class="blank _f"> </span>vivo<span class="blank"> </span></span><span class="lsf ws28">o<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>determ<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10">on</span></span></span></div><div class="t m1 x14 h1e yf1 ffb fs2 fc0 sc0 lsc ws48">de<span class="blank _4"> </span>lo<span class="blank"> </span>s<span class="blank _4"> </span>nivel<span class="blank"> </span>es<span class="blank _2"> </span>i<span class="blank"> </span>ntra<span class="blank"> </span>cel<span class="blank"> </span>ul<span class="blank"> </span>a<span class="blank"> </span>res<span class="blank _4"> </span>de<span class="blank _4"> </span>P<span class="ls6 ws92 v0">Cho<span class="blank"> </span>(an´<span class="blank _5"></span><span class="ls1b wsbd">alisis<span class="blank"> </span><span class="ffe ls10 wsc0">in<span class="blank"> </span>vitr<span class="blank _1c"></span>o<span class="ffb ls2f ws16">).<span class="blank _13"> </span>A<span class="blank _2"> </span>continuaci´<span class="blank _1b"></span><span class="lsc ws57">o<span class="blank"> </span>n<span class="blank _4"> </span>se<span class="blank _4"> </span>deta<span class="blank"> </span>l<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank"> </span>,<span class="blank _4"> </span>com<span class="blank"> </span>o<span class="blank _4"> </span>ej<span class="blank"> </span>em<span class="blank"> </span>pl<span class="blank _3"> </span>os,<span class="blank _4"> </span>un</span></span></span></span></span></div><div class="t m1 x14 h4 yf2 ffb fs2 fc0 sc0 ls3d ws4b">m´<span class="blank _6"></span><span class="ls10 wsc1">etodo<span class="blank _f"> </span>para<span class="blank"> </span>c<span class="blank _1c"></span>ada<span class="blank"> </span>an´<span class="blank _1b"></span><span class="ls1b ws6c">alisis:</span></span></div><div class="t m1 x14 h4 yf3 ffb fs2 fc0 sc0 ls1c wsc2">3.2.1.-<span class="blank"> </span><span class="ffe ls2f ws6f">Ejemplo<span class="blank _4"> </span>del<span class="blank _2"> </span>ensayo<span class="blank _4"> </span>ex<span class="blank _2"> </span>vivo<span class="blank _2"> </span>de<span class="blank _2"> </span>i<span class="blank"> </span>nhibi<span class="blank"> </span>dores<span class="blank _2"> </span>de<span class="blank _2"> </span>la<span class="blank _2"> </span>c<span class="blank _1c"></span>oli<span class="blank"> </span>na<span class="blank _2"> </span>qui<span class="blank"> </span>nasa</span></div><div class="t m1 x13 h4 yf4 ffb fs2 fc0 sc0 ls1c ws76">En<span class="blank"> </span>n<span class="blank _1c"></span>uest<span class="blank _c"></span>ro<span class="blank _12"> </span>ensa<span class="blank _1c"></span>yo<span class="blank"> </span>utiliz<span class="blank _1c"></span>amos,<span class="blank"> </span>por<span class="blank"> </span>su<span class="blank _f"> </span>se<span class="blank _1c"></span>ncille<span class="blank _c"></span>z<span class="blank _f"> </span>y<span class="blank"> </span>ec<span class="blank _1c"></span>onom<span class="blank _1"></span>´<span class="blank _b"></span>\u0131a,<span class="blank"> </span>colina<span class="blank _0"> </span>quin<span class="blank _c"></span>asa<span class="blank"> </span>de<span class="blank"> </span>lev<span class="blank _1"></span>adur<span class="blank _c"></span>as<span class="blank"> </span>come<span class="blank _c"></span>rc<span class="blank _c"></span>ializad<span class="blank _c"></span>a</div><div class="t m1 x14 h4 yf5 ffb fs2 fc0 sc0 ls1c ws73">por<span class="blank"> </span>div<span class="blank _1c"></span>ers<span class="blank _1c"></span>as<span class="blank"> </span>\ufb01r<span class="blank _c"></span>mas.<span class="blank _8"> </span>Se<span class="blank"> </span>pu<span class="blank _c"></span>ede<span class="blank"> </span>u<span class="blank _c"></span>tiliz<span class="blank _c"></span>ar<span class="blank _12"> </span>tam<span class="blank _c"></span>bi<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls14 ws40">en<span class="blank _12"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _f"> </span>quinasa<span class="blank _f"> </span>de<span class="blank _f"> </span>c´<span class="blank _5"></span>elulas<span class="blank _f"> </span>de<span class="blank _f"> </span>m<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank _1"></span>´<span class="blank _a"></span>\u0131f<span class="blank"> </span>eros,<span class="blank _f"> </span>incluyendo<span class="blank _12"> </span>huma-</span></div><div class="t m1 x14 h4 yf6 ffb fs2 fc0 sc0 lsf ws28">nos.<span class="blank _9"> </span>El<span class="blank _2"> </span>pro<span class="blank _3"> </span>cedi<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank"> </span>ento<span class="blank _2"> </span>exp<span class="blank _3"> </span>eri<span class="blank"> </span>m<span class="blank"> </span>ental<span class="blank _2"> </span>es<span class="blank _4"> </span>como<span class="blank _2"> </span>se<span class="blank _2"> </span>descri<span class="blank"> </span>b<span class="blank _3"> </span>e<span class="blank _4"> </span>a<span class="blank _f"> </span>co<span class="blank"> </span>ntinua<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws72">on:</span></div><div class="t m1 x13 h4 yf7 ffb fs2 fc0 sc0 ls2f ws78">\u201c-<span class="blank"> </span>Se<span class="blank"> </span>pre<span class="blank _c"></span>para<span class="blank"> </span>e<span class="blank"> </span>tamp<span class="blank _3"> </span>´<span class="blank _1b"></span><span class="ls10 ws60">on<span class="blank"> </span>de<span class="blank"> </span>reac<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="ls1e wsc3">on<span class="blank _2"> </span>10X<span class="blank"> </span>(lM<span class="blank"> </span>T<span class="blank _1"></span>ris<span class="blank"> </span>pH<span class="blank _f"> </span>8,0,<span class="blank"> </span>100<span class="blank"> </span>mM<span class="blank"> </span>MgCl2<span class="blank"> </span>y<span class="blank _f"> </span>2<span class="blank _f"> </span>mM<span class="blank"> </span>(</span></span></div><div class="t m1 x27 h1f yf8 ff5 fs5 fc0 sc0 ls3e wsc4">14<span class="blank"> </span><span class="ffb fs2 lsb wsc5 v5">C)-<span class="blank _c"></span>met<span class="blank _c"></span>il-Colin<span class="blank _c"></span>a</span></div><div class="t m1 x14 h4 y86 ffb fs2 fc0 sc0 ls2f wsc6">(20<span class="blank"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls1e ws61">Ci/ml),<span class="blank"> </span>A<span class="blank _1"></span>TP<span class="blank _f"> </span>100<span class="blank _f"> </span>mM)</span></div><div class="t m1 x18 h4 yf9 ffb fs2 fc0 sc0 ls9">4</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf5" class="pf w0 h0" data-page-no="5"><div class="pc pc5 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x1d yfa w5 h20" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg5.png"><div class="t m1 x1a he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x1b hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x1c hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x1c hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x1c hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x1c hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x1c hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x1c hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x1c hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x1c hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x1c hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x1c hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x1c hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x14 h4 y51 ffb fs2 fc0 sc0 ls2f ws49">-<span class="blank _8"> </span>Se<span class="blank _9"> </span>prepara<span class="blank _9"> </span>una<span class="blank _8"> </span>sol<span class="blank"> </span>uci´<span class="blank _5"></span>on<span class="blank _9"> </span>de<span class="blank _4"> </span>col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _8"> </span>qui<span class="blank"> </span>na<span class="blank"> </span>sa<span class="blank _9"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>ev<span class="blank _c"></span>adura<span class="blank _9"> </span>(50<span class="blank _8"> </span>m<span class="blank"> </span>U/m<span class="blank"> </span>l<span class="blank"> </span>)<span class="blank _4"> </span>a<span class="blank _9"> </span>partir<span class="blank _8"> </span>de<span class="blank _9"> </span>una<span class="blank _8"> </span>prepara<span class="blank"> </span>ci´<span class="blank _b"></span><span class="ls10">on</span></div><div class="t m1 x1d h4 yc6 ffb fs2 fc0 sc0 ls1b wsc8">come<span class="blank _1c"></span>rcial<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _2"> </span>1U<span class="blank _c"></span>/ml.</div><div class="t m1 x14 h4 y8c ffb fs2 fc0 sc0 ls8 wsc9">-<span class="blank"> </span>Se<span class="blank"> </span>pre<span class="blank _1c"></span>paran<span class="blank _f"> </span>las<span class="blank"> </span>dis<span class="blank _c"></span>tin<span class="blank _1c"></span>tas<span class="blank"> </span>conc<span class="blank _1c"></span>en<span class="blank _c"></span>trac<span class="blank _1c"></span>iones<span class="blank"> </span>de<span class="blank _f"> </span>los<span class="blank"> </span>co<span class="blank _c"></span>mpue<span class="blank _c"></span>stos<span class="blank"> </span>a<span class="blank"> </span>analizar<span class="blank _c"></span>,<span class="blank"> </span>con<span class="blank"> </span>un<span class="blank _c"></span>a<span class="blank"> </span>conc<span class="blank _c"></span>en<span class="blank _1c"></span>trac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 ws5a">on<span class="blank _f"> </span>de<span class="blank"> </span>5X</span></div><div class="t m1 x1d h4 yfb ffb fs2 fc0 sc0 ls10 wsca">en<span class="blank"> </span>agua.</div><div class="t m1 x14 h4 yfc ffb fs2 fc0 sc0 lsc ws38">-<span class="blank _4"> </span>Se<span class="blank _4"> </span>m<span class="blank"> </span>ezcl<span class="blank _3"> </span>an<span class="blank _8"> </span>2<span class="blank"> </span>0<span class="blank _4"> </span>m<span class="blank"> </span>l<span class="blank _4"> </span>del<span class="blank _9"> </span>bu\ufb00er<span class="blank _8"> </span>de<span class="blank _4"> </span>reacci<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls10 wscb">on<span class="blank _4"> </span>+<span class="blank"> </span>10<span class="blank _4"> </span><span class="ffd ls9 wsc7">µ</span><span class="lsf ws58">l<span class="blank _4"> </span>d<span class="blank"> </span>el<span class="blank _8"> </span>com<span class="blank"> </span>p<span class="blank"> </span>uest<span class="blank"> </span>o<span class="blank _4"> </span>(o<span class="blank _8"> </span>ag<span class="blank"> </span>u<span class="blank"> </span>a<span class="blank _4"> </span>en<span class="blank _4"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _4"> </span>co<span class="blank"> </span>ntrol<span class="blank _3"> </span>es)<span class="blank _4"> </span>+<span class="blank _4"> </span>1<span class="blank"> </span>0<span class="blank _8"> </span><span class="ffd ls9 wsc7">µ<span class="ffb">l</span></span></span></span></div><div class="t m1 x1d h4 yfd ffb fs2 fc0 sc0 ls10 wscc">agua<span class="blank"> </span>+<span class="blank"> </span>10<span class="blank"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls14 ws40">l<span class="blank _2"> </span>colina<span class="blank _2"> </span>quinasa.</span></div><div class="t m1 x14 h21 yfe ffb fs2 fc0 sc0 ls14 ws40">-<span class="blank _2"> </span>Se<span class="blank _f"> </span>incuba<span class="blank _2"> </span>45<span class="blank _f"> </span>mi<span class="blank"> </span>n.<span class="blank _8"> </span>a<span class="blank _2"> </span>37<span class="blank"> </span><span class="ff8 fs5 ls3f v4">\u25e6</span><span class="ls6 v0">C.</span></div><div class="t m1 x14 h4 yff ffb fs2 fc0 sc0 lsf ws28">-<span class="blank _2"> </span>Se<span class="blank _2"> </span>detien<span class="blank"> </span>e<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>reacci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws43">on<span class="blank _2"> </span>a<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls14 ws40">nadiendo<span class="blank _f"> </span>1<span class="blank"> </span>0<span class="blank _f"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls8 wscd">l<span class="blank _2"> </span>EDT<span class="blank _1"></span>A<span class="blank"> </span>500<span class="blank _12"> </span>mM<span class="blank"> </span>y<span class="blank"> </span>se<span class="blank"> </span>man<span class="blank _c"></span>tie<span class="blank _c"></span>nen<span class="blank"> </span>las<span class="blank _12"> </span>mu<span class="blank _c"></span>es<span class="blank _c"></span>tras<span class="blank"> </span>en<span class="blank"> </span>h<span class="blank _c"></span>ielo.</span></span></span></div><div class="t m1 x14 h4 y100 ffb fs2 fc0 sc0 lsc ws38">-<span class="blank _9"> </span>Se<span class="blank _9"> </span>resu<span class="blank"> </span>el<span class="blank _3"> </span>ven<span class="blank _9"> </span>a<span class="blank"> </span>l<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls1c ws82">\u0131c<span class="blank _c"></span>uotas<span class="blank"> </span>e<span class="blank _1c"></span>quiv<span class="blank _1c"></span>alen<span class="blank _1c"></span>tes<span class="blank"> </span>(30<span class="blank"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls10 ws5b">l<span class="blank _9"> </span>de<span class="blank _8"> </span>cada<span class="blank _9"> </span>m<span class="blank _c"></span>ues<span class="blank _c"></span>tra)<span class="blank _8"> </span>por<span class="blank _9"> </span>cromat<span class="blank _c"></span>ograf<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls14 ws40">\u0131<span class="blank"> </span>a<span class="blank _8"> </span>en<span class="blank _9"> </span>capa<span class="blank _9"> </span>\ufb01na<span class="blank _9"> </span>uti-</span></span></span></div><div class="t m1 x1d h4 y101 ffb fs2 fc0 sc0 ls14 ws40">lizando<span class="blank _13"> </span>placas<span class="blank _7"> </span>de<span class="blank _14"> </span>gel<span class="blank _7"> </span>de<span class="blank _14"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls8 wsce">\u0131lice<span class="blank"> </span>como<span class="blank"> </span>s<span class="blank _c"></span>oporte<span class="blank"> </span>y<span class="blank _13"> </span>como<span class="blank"> </span>fase<span class="blank"> </span>m´<span class="blank _1b"></span>ovil<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank _13"> </span>tamp´<span class="blank _1b"></span><span class="ls1e wscf">on<span class="blank"> </span>siguien<span class="blank _1c"></span>te:<span class="blank _25"> </span>0,9%<span class="blank"> </span>clor<span class="blank _c"></span>uro</span></span></div><div class="t m1 x1d h4 y102 ffb fs2 fc0 sc0 ls31 ws80">s´<span class="blank _5"></span><span class="ls1b ws6c">odic<span class="blank _c"></span>o:met<span class="blank _c"></span>anol:h<span class="blank _c"></span>idr´<span class="blank _1b"></span><span class="ls8 ws98">oxido<span class="blank"> </span>a<span class="blank _c"></span>m´<span class="blank _1b"></span>onico<span class="blank _9"> </span>(50:70:1;<span class="blank _7"> </span>v:v:v).<span class="blank _26"> </span>Se<span class="blank _9"> </span>res<span class="blank _c"></span>ue<span class="blank _c"></span>lv<span class="blank _c"></span>en<span class="blank _7"> </span>en<span class="blank _7"> </span>par<span class="blank _c"></span>alelo<span class="blank _8"> </span>est<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls2f ws16">anda<span class="blank"> </span>res<span class="blank _14"> </span>sin<span class="blank _c"></span>t´<span class="blank _5"></span><span class="lsc ws38">eti<span class="blank"> </span>co<span class="blank _3"> </span>s<span class="blank _7"> </span>de</span></span></span></span></div><div class="t m1 x1d h4 y103 ffb fs2 fc0 sc0 ls1c ws9a">colin<span class="blank _c"></span>a<span class="blank"> </span>y<span class="blank _f"> </span>fosforilc<span class="blank _c"></span>olina<span class="blank"> </span>rad<span class="blank _c"></span>iact<span class="blank _c"></span>iv<span class="blank _c"></span>os<span class="blank"> </span>como<span class="blank"> </span>indica<span class="blank _c"></span>dore<span class="blank _1c"></span>s.</div><div class="t m1 x14 h22 y104 ffb fs2 fc0 sc0 lsf ws58">-<span class="blank _2"> </span>S<span class="blank"> </span>e<span class="blank _4"> </span>i<span class="blank"> </span>denti<span class="blank"> </span>\ufb01ca<span class="blank"> </span>n<span class="blank _4"> </span>la<span class="blank"> </span>s<span class="blank _4"> </span>man<span class="blank"> </span>chas<span class="blank _2"> </span>r<span class="blank"> </span>a<span class="blank"> </span>di<span class="blank _3"> </span>acti<span class="blank _3"> </span>v<span class="blank _c"></span>as<span class="blank _2"> </span>co<span class="blank"> </span>rresp<span class="blank _3"> </span>o<span class="blank"> </span>nd<span class="blank"> </span>i<span class="blank"> </span>entes<span class="blank _9"> </span>a<span class="blank _2"> </span>col<span class="blank _3"> </span>in<span class="blank"> </span>a<span class="blank _2"> </span>y<span class="blank _4"> </span>P<span class="ls10 wsb4 v0">Cho<span class="blank"> </span>y<span class="blank _4"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>cuan<span class="blank _c"></span>ti\ufb01c<span class="blank _c"></span>an<span class="blank"> </span>median<span class="blank _1c"></span>te</span></div><div class="t m1 x1d h4 y9c ffb fs2 fc0 sc0 lsb wsd0">la<span class="blank"> </span>t<span class="blank _1c"></span>´<span class="blank _6"></span><span class="lsc ws48">ecni<span class="blank"> </span>ca<span class="blank _4"> </span>de<span class="blank _2"> </span>cen<span class="blank _c"></span>tel<span class="blank"> </span>l<span class="blank"> </span>eo<span class="blank _2"> </span>l<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls2f ws16">\u0131quido<span class="blank _f"> </span>(se<span class="blank _2"> </span>raspan<span class="blank _f"> </span>la<span class="blank"> </span>s<span class="blank _2"> </span>manchas<span class="blank _f"> </span>correspo<span class="blank"> </span>d<span class="blank"> </span>i<span class="blank"> </span>ente<span class="blank _c"></span>s<span class="blank _4"> </span>tras<span class="blank _f"> </span>exp<span class="blank _3"> </span>osici<span class="blank"> </span>´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _2"> </span>de<span class="blank _f"> </span>un<span class="blank _2"> </span>\ufb01lm<span class="blank _f"> </span>sens<span class="blank _c"></span>ibl<span class="blank"> </span>e</span></span></span></div><div class="t m1 x1d h4 y9d ffb fs2 fc0 sc0 ls1c ws4f">a<span class="blank"> </span>r<span class="blank _1c"></span>adiactiv<span class="blank _c"></span>idad)<span class="blank _12"> </span>o<span class="blank"> </span>median<span class="blank _1c"></span>te<span class="blank _f"> </span>un<span class="blank _f"> </span>sis<span class="blank _1c"></span>tema<span class="blank"> </span>e<span class="blank _c"></span>lec<span class="blank _c"></span>tr<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls8 wsd1">onico<span class="blank"> </span>aut<span class="blank _c"></span>om´<span class="blank _1b"></span><span class="ls1c ws64">atico<span class="blank"> </span>c<span class="blank _c"></span>on<span class="blank _1c"></span>ve<span class="blank _c"></span>ncion<span class="blank _c"></span>al.</span></span></div><div class="t m1 x14 h4 y105 ffb fs2 fc0 sc0 ls2d ws39">-<span class="blank _2"> </span>El<span class="blank _f"> </span>efecto<span class="blank _2"> </span>de<span class="blank _2"> </span>cada<span class="blank _2"> </span>compuesto<span class="blank _f"> </span>ana<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>zado<span class="blank _2"> </span>sobre<span class="blank _2"> </span>la<span class="blank _f"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _1b"></span><span class="ls10 ws83">on<span class="blank _2"> </span>de<span class="blank"> </span>P</span></div><div class="t m1 x28 h4 y106 ffb fs2 fc0 sc0 ls2d ws39">Cho<span class="blank _2"> </span>se<span class="blank _2"> </span>det<span class="blank _c"></span>ermina<span class="blank _2"> </span>medi<span class="blank"> </span>ante<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>no<span class="blank"> </span>r-</div><div class="t m1 x1d h4 y107 ffb fs2 fc0 sc0 ls1c ws3a">malizac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls8 wsd2">on<span class="blank _12"> </span>de<span class="blank"> </span>los<span class="blank"> </span>v<span class="blank _1"></span>alores<span class="blank _12"> </span>de<span class="blank _2"> </span>rad<span class="blank _c"></span>iactivid<span class="blank _c"></span>ad<span class="blank _12"> </span>de<span class="blank"> </span>es<span class="blank _c"></span>te<span class="blank"> </span>metabolito<span class="blank"> </span>fr<span class="blank _c"></span>en<span class="blank _1c"></span>te<span class="blank"> </span>a<span class="blank"> </span>los<span class="blank"> </span>niv<span class="blank _1c"></span>eles<span class="blank"> </span>de<span class="blank"> </span>r<span class="blank _c"></span>adiac<span class="blank _c"></span>tividad<span class="blank _0"> </span>totales</span></div><div class="t m1 x1d h4 y108 ffb fs2 fc0 sc0 ls1b ws94">(c<span class="blank _c"></span>olina<span class="blank"> </span>+<span class="blank"> </span>P</div><div class="t m1 x29 h4 y109 ffb fs2 fc0 sc0 ls43 wsd3">Cho<span class="blank"> </span>)<span class="blank _2"> </span>en<span class="blank _2"> </span>ca<span class="blank"> </span>da<span class="blank _2"> </span>mu<span class="blank"> </span>estr<span class="blank"> </span>a<span class="blank"> </span>\u201d<span class="blank"> </span>.</div><div class="t m1 x1d h4 y10a ffb fs2 fc0 sc0 ls1c wsc2">3.2.2.-<span class="blank"> </span><span class="ffe ls2f ws6f">Ejemplo<span class="blank _4"> </span>del<span class="blank _2"> </span>ensayo<span class="blank _4"> </span>in<span class="blank _f"> </span>vi<span class="blank"> </span>t<span class="blank"> </span>ro<span class="blank _2"> </span>de<span class="blank _2"> </span>inhibidores<span class="blank _f"> </span>de<span class="blank _2"> </span>l<span class="blank _3"> </span>a<span class="blank _2"> </span>c<span class="blank _1c"></span>oli<span class="blank"> </span>na<span class="blank _2"> </span>qui<span class="blank"> </span>nasa</span></div><div class="t m1 x14 h4 y10b ffb fs2 fc0 sc0 ls8 wsd4">En<span class="blank"> </span>n<span class="blank _1c"></span>ues<span class="blank _c"></span>tro<span class="blank _8"> </span>ens<span class="blank _c"></span>ay<span class="blank _1c"></span>o<span class="blank"> </span>se<span class="blank"> </span>han<span class="blank"> </span>utiliz<span class="blank _c"></span>ado<span class="blank _2"> </span>tant<span class="blank _c"></span>o<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _6"></span><span class="ls2f ws16">elula<span class="blank"> </span>s<span class="blank _8"> </span>de<span class="blank _8"> </span>rat´<span class="blank _5"></span><span class="ls8 wsd5">on<span class="blank _8"> </span>como<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls14 ws40">elul<span class="blank"> </span>as<span class="blank _9"> </span>h<span class="blank _1c"></span>um<span class="blank"> </span>a<span class="blank"> </span>nas<span class="blank _8"> </span>disp<span class="blank"> </span>o<span class="blank"> </span>ni<span class="blank"> </span>bl<span class="blank"> </span>es<span class="blank _4"> </span>como</span></span></span></div><div class="t m1 x1d h4 y10c ffb fs2 fc0 sc0 ls1c ws61">cu<span class="blank _c"></span>ltiv<span class="blank _1c"></span>os<span class="blank"> </span>inmortaliz<span class="blank _c"></span>ados<span class="blank _c"></span>:</div><div class="t m1 x14 h4 y10d ffb fs2 fc0 sc0 ls2d ws49">\u201c-<span class="blank _2"> </span>Se<span class="blank _2"> </span>si<span class="blank"> </span>embran<span class="blank _2"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span>el<span class="blank"> </span>ul<span class="blank"> </span>as<span class="blank _2"> </span>de<span class="blank _2"> </span>ra<span class="blank"> </span>t´<span class="blank _5"></span><span class="ls10 ws3d">on<span class="blank _2"> </span>o<span class="blank _2"> </span>h<span class="blank _c"></span>umanas<span class="blank"> </span>en<span class="blank _2"> </span>placas<span class="blank"> </span>de<span class="blank _2"> </span>pl´<span class="blank _1b"></span><span class="ls8 wsd1">astic<span class="blank _1c"></span>o<span class="blank"> </span>de<span class="blank"> </span>6<span class="blank"> </span>po<span class="blank _3"> </span>cillos<span class="blank _f"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>el<span class="blank"> </span>medio<span class="blank _f"> </span>ade<span class="blank _c"></span>cuad<span class="blank _c"></span>o</span></span></div><div class="t m1 x1d h4 y10e ffb fs2 fc0 sc0 lsf ws58">(DM<span class="blank"> </span>EM<span class="blank _2"> </span>o<span class="blank _f"> </span>equ<span class="blank"> </span>i<span class="blank"> </span>valente<span class="blank _f"> </span>sup<span class="blank"> </span>l<span class="blank"> </span>em<span class="blank"> </span>enta<span class="blank"> </span>do<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank _2"> </span>10%<span class="blank _2"> </span>suero<span class="blank _2"> </span>fet<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank _2"> </span>o<span class="blank _f"> </span>de<span class="blank _f"> </span>t<span class="blank"> </span>ernera<span class="blank _4"> </span>reci´<span class="blank _6"></span><span class="ls2d ws39">en<span class="blank _2"> </span>nacida).<span class="blank _9"> </span>Se<span class="blank _f"> </span>a<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls1e ws84">naden<span class="blank"> </span>200.000</span></span></div><div class="t m1 x1d h4 y10f ffb fs2 fc0 sc0 ls36 ws6f">c´<span class="blank _6"></span><span class="ls8 ws50">elulas<span class="blank _12"> </span>por<span class="blank _12"> </span>p<span class="blank"> </span>o<span class="blank _3"> </span>cillo.<span class="blank _4"> </span>Se<span class="blank _0"> </span>hace<span class="blank _c"></span>n<span class="blank _f"> </span>cr<span class="blank _c"></span><span class="ls32 ws49">ecer<span class="blank _2"> </span>hasta<span class="blank _f"> </span>que<span class="blank _f"> </span>alca<span class="blank"> </span>nza<span class="blank"> </span>n<span class="blank _f"> </span>con\ufb02uencia<span class="blank _2"> </span>en<span class="blank _f"> </span>un<span class="blank _12"> </span>i<span class="blank _3"> </span>ncubador<span class="blank _f"> </span>con<span class="blank _f"> </span>5%<span class="blank _f"> </span>de<span class="blank _12"> </span>CO</span></span></div><div class="t m1 x2a h11 y110 ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls10 ws56 v3">,<span class="blank"> </span>95%</span></div><div class="t m1 x1d h23 y111 ffb fs2 fc0 sc0 ls8 ws61">aire<span class="blank"> </span>y<span class="blank"> </span>90%<span class="blank _2"> </span>h<span class="blank _1c"></span>umeda<span class="blank _c"></span>d,<span class="blank"> </span>a<span class="blank _2"> </span>37<span class="ff8 fs5 ls40 v4">\u25e6</span><span class="ls6 v0">C.</span></div><div class="t m1 x14 h4 y112 ffb fs2 fc0 sc0 ls2d ws39">-<span class="blank _12"> </span>No<span class="blank"> </span>rm<span class="blank"> </span>al<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _12"> </span>a<span class="blank _f"> </span>la<span class="blank"> </span>s<span class="blank _f"> </span>48<span class="blank _12"> </span>ho<span class="blank"> </span>ras<span class="blank _f"> </span>se<span class="blank _2"> </span>alcanza<span class="blank _f"> </span>la<span class="blank _12"> </span>con\ufb02uencia<span class="blank"> </span>.<span class="blank _9"> </span>En<span class="blank _f"> </span>este<span class="blank _f"> </span>pun<span class="blank _c"></span>to<span class="blank _f"> </span>se<span class="blank _f"> </span>lav<span class="blank _1c"></span>a<span class="blank"> </span>n<span class="blank _12"> </span>la<span class="blank"> </span>s<span class="blank _f"> </span>pla<span class="blank"> </span>cas<span class="blank _f"> </span>con<span class="blank _f"> </span>tamp´<span class="blank _5"></span><span class="ls10">on</span></div><div class="t m1 x1d h4 y113 ffb fs2 fc0 sc0 ls2d ws4d">TD<span class="blank _9"> </span>(50<span class="blank _9"> </span>m<span class="blank"> </span>M<span class="blank _7"> </span>fosfa<span class="blank"> </span>to<span class="blank _9"> </span>s´<span class="blank _5"></span><span class="ls1e wsd6">odico,<span class="blank"> </span>150<span class="blank"> </span>mM<span class="blank _9"> </span>clorur<span class="blank _c"></span>o<span class="blank _9"> </span>s´<span class="blank _1b"></span><span class="ls8 wsd7">odico,<span class="blank"> </span>5<span class="blank"> </span>mM<span class="blank _9"> </span>c<span class="blank _c"></span>lorur<span class="blank _c"></span>o<span class="blank"> </span>pot´<span class="blank _1b"></span>asico,<span class="blank"> </span>pH<span class="blank"> </span>7,4)<span class="blank _4"> </span>y<span class="blank"> </span>se<span class="blank"> </span>a\u02dc<span class="blank _1b"></span><span class="ls14 wsd8">naden<span class="blank"> </span>2</span></span></span></div><div class="t m1 x1d h4 y114 ffb fs2 fc0 sc0 ls1c ws7d">ml/po<span class="blank _3"> </span>c<span class="blank _c"></span>illo<span class="blank _f"> </span>de<span class="blank"> </span>med<span class="blank _c"></span>io<span class="blank"> </span>DM<span class="blank _c"></span>EM<span class="blank"> </span>s<span class="blank _c"></span>uple<span class="blank _c"></span>men<span class="blank _1c"></span>tado<span class="blank"> </span>c<span class="blank _1c"></span>on<span class="blank"> </span>0.5%<span class="blank _2"> </span>de<span class="blank"> </span>s<span class="blank _c"></span>uer<span class="blank _1c"></span>o<span class="blank"> </span>de<span class="blank"> </span>tern<span class="blank _c"></span>er<span class="blank _c"></span>a.<span class="blank _16"> </span>Se<span class="blank _2"> </span>a\u02dc<span class="blank _1b"></span>nade<span class="blank _2"> </span>a<span class="blank"> </span>c<span class="blank _c"></span>ada<span class="blank"> </span>po<span class="blank _3"> </span>c<span class="blank _c"></span>illo<span class="blank _f"> </span>una</div><div class="t m1 x1d h4 y115 ffb fs2 fc0 sc0 ls8 wsd9">can<span class="blank _1c"></span>tidad<span class="blank _2"> </span>c<span class="blank _c"></span>re<span class="blank _c"></span>cie<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _8"> </span>de<span class="blank _2"> </span>los<span class="blank"> </span>c<span class="blank _c"></span>ompue<span class="blank _c"></span>st<span class="blank _c"></span>os<span class="blank"> </span>a<span class="blank"> </span>analiz<span class="blank _c"></span>ar,<span class="blank _2"> </span>dis<span class="blank _c"></span>uelt<span class="blank _c"></span>as<span class="blank"> </span>en<span class="blank"> </span>el<span class="blank _2"> </span>mismo<span class="blank _2"> </span>med<span class="blank _c"></span>io,<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>forma<span class="blank _2"> </span>que<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>cons<span class="blank _1c"></span>i<span class="blank _3"> </span>ga</div><div class="t m1 x1d h4 y116 ffb fs2 fc0 sc0 lse ws2c">una<span class="blank"> </span>c<span class="blank _c"></span>urv<span class="blank _1c"></span>a<span class="blank"> </span>cr<span class="blank _c"></span>ecie<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _2"> </span>que<span class="blank _12"> </span>abarque<span class="blank"> </span>un<span class="blank"> </span>r<span class="blank _c"></span>ango<span class="blank"> </span>de<span class="blank _12"> </span>al<span class="blank"> </span>m<span class="blank _3"> </span>e<span class="blank _c"></span>nos<span class="blank"> </span>1000<span class="blank _12"> </span>v<span class="blank _c"></span><span class="lsc ws57">eces<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>co<span class="blank"> </span>n<span class="blank"> </span>centraci<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls1e wsda">on<span class="blank _2"> </span>me<span class="blank _c"></span>nor<span class="blank"> </span>e<span class="blank _c"></span>mplead<span class="blank _c"></span>a,<span class="blank"> </span>que</span></span></div><div class="t m1 x1d h4 y117 ffb fs2 fc0 sc0 ls15 ws6b">estar´<span class="blank _5"></span><span class="ls8 wsdb">a<span class="blank"> </span>en<span class="blank"> </span>tor<span class="blank _c"></span>no<span class="blank"> </span>a<span class="blank"> </span>0,1<span class="blank _f"> </span>mic<span class="blank _c"></span>romolar<span class="blank _0"> </span>(<span class="ffd ls9 wsc7">µ</span><span class="ls2d ws39">M).<span class="blank _2"> </span>Se<span class="blank _2"> </span>incuba<span class="blank _f"> </span>dura<span class="blank"> </span>nte<span class="blank _f"> </span>una<span class="blank _2"> </span>hora<span class="blank _2"> </span>en<span class="blank _f"> </span>condi<span class="blank"> </span>cio<span class="blank"> </span>nes<span class="blank _2"> </span>es<span class="blank _c"></span>t´<span class="blank _1b"></span>a<span class="blank"> </span>nda<span class="blank"> </span>rd.</span></span></div><div class="t m1 x14 h4 y118 ffb fs2 fc0 sc0 ls44 wsdc">-S<span class="blank _a"></span>e<span class="blank"> </span>a<span class="blank _19"></span>\u02dc<span class="blank _21"></span><span class="ls14 wsdd">nade<span class="blank _c"></span>n<span class="blank _4"> </span>0,<span class="blank"> </span>5<span class="blank"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls1c ws88">Ci/po<span class="blank _3"> </span>cillo<span class="blank _f"> </span>de<span class="blank _2"> </span>(</span></span></div><div class="t m1 x2b h1f y119 ff5 fs5 fc0 sc0 ls3e wsde">14<span class="ffb fs2 ls2d ws39 v5">C)<span class="blank _4"> </span>metil-<span class="blank"> </span>coli<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _2"> </span>como<span class="blank _4"> </span>prec<span class="blank _c"></span>ursor<span class="blank _4"> </span>ra<span class="blank"> </span>di<span class="blank"> </span>acti<span class="blank"> </span>vo.<span class="blank _13"> </span>Se<span class="blank _4"> </span>incuban<span class="blank _4"> </span>en<span class="blank _4"> </span>condi-</span></div><div class="t m1 x1d h10 y11a ffb fs2 fc0 sc0 lsc ws38">cio<span class="blank _3"> </span>nes<span class="blank _2"> </span>est´<span class="blank _5"></span><span class="ls14 wsb7">andar<span class="blank _2"> </span>de<span class="blank"> </span>CO<span class="ff5 fs5 ls41 v6">2</span><span class="ls10 ws59 v0">y<span class="blank _2"> </span>h<span class="blank _1c"></span>umedad<span class="blank"> </span>duran<span class="blank _1c"></span>te<span class="blank _2"> </span>12-14<span class="blank"> </span>horas<span class="blank _c"></span>.</span></span></div><div class="t m1 x14 h4 y11b ffb fs2 fc0 sc0 ls45 wsdf">-S<span class="blank _b"></span>el<span class="blank _a"></span>a<span class="blank _a"></span>v<span class="blank _b"></span>a<span class="blank _b"></span>nl<span class="blank _b"></span>a<span class="blank _a"></span>sc<span class="blank _b"></span>´<span class="blank _21"></span><span class="lsc ws57">el<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _4"> </span>co<span class="blank"> </span>n<span class="blank _4"> </span>ta<span class="blank"> </span>m<span class="blank"> </span>p<span class="blank"> </span>´<span class="blank _5"></span><span class="ls30 ws43">o<span class="blank"> </span>n<span class="blank _4"> </span>TD<span class="blank _8"> </span>y<span class="blank _4"> </span>se<span class="blank _2"> </span>p<span class="blank"> </span>ro<span class="blank _3"> </span>cesan<span class="blank _9"> </span>para<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>determi<span class="blank"> </span>na<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _4"> </span>del<span class="blank _4"> </span>con<span class="blank _c"></span>tenido<span class="blank _8"> </span>celular<span class="blank _4"> </span>en</span></span></span></div><div class="t m1 x1d h13 y11c ffb fs2 fc0 sc0 ls9 wse0">P<span class="ls1f ws58 v0">Cho.<span class="blank _13"> </span>Se<span class="blank _2"> </span>a<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls1b ws18">nade<span class="blank _f"> </span>1<span class="blank"> </span>ml/p<span class="blank _3"> </span>ocillo<span class="blank _f"> </span>de<span class="blank"> </span>u<span class="blank _c"></span>na<span class="blank"> </span>so<span class="blank _c"></span>luci´<span class="blank _1b"></span><span class="ls10 wsb4">on<span class="blank"> </span>ac<span class="blank _c"></span>uosa<span class="blank"> </span>de<span class="blank"> </span>´<span class="blank _1b"></span><span class="ls1e wse1">acido<span class="blank"> </span>tr<span class="blank _c"></span>icloroac<span class="blank _1"></span>´<span class="blank _6"></span><span class="lsc ws57">eti<span class="blank"> </span>co<span class="blank _4"> </span>(TC<span class="blank"> </span>A)<span class="blank _4"> </span>a<span class="blank"> </span>l<span class="blank _4"> </span>16%<span class="blank _3"> </span>.<span class="blank _14"> </span>Se<span class="blank _2"> </span>dej<span class="blank"> </span>a<span class="blank _4"> </span>1</span></span></span></span></span></div><div class="t m1 x1d h23 y11d ffb fs2 fc0 sc0 ls31 ws46">hora<span class="blank _2"> </span>en<span class="blank _2"> </span>c´<span class="blank _1b"></span><span class="ls1e wse2">amara<span class="blank"> </span>fr<span class="blank _d"></span>´<span class="blank _a"></span><span class="lsb wsd0">\u0131a<span class="blank"> </span>(4<span class="ff8 fs5 ls40 v4">\u25e6</span><span class="ls1c ws4d v0">C).<span class="blank _f"> </span>Es<span class="blank _c"></span>te<span class="blank _f"> </span>proces<span class="blank _1c"></span>amien<span class="blank _c"></span>to<span class="blank _f"> </span>\ufb01ja<span class="blank _f"> </span>las<span class="blank _f"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls8 ws56">elulas<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _2"> </span>los<span class="blank"> </span>p<span class="blank _3"> </span>ocillos<span class="blank"> </span>y<span class="blank _f"> </span>extr<span class="blank _c"></span>ae<span class="blank _f"> </span>el<span class="blank _f"> </span>material<span class="blank"> </span>solu<span class="blank _c"></span>ble</span></span></span></span></div><div class="t m1 x1d h10 y11e ffb fs2 fc0 sc0 lsc ws57">en<span class="blank _2"> </span>el<span class="blank _2"> </span>TCA<span class="blank"> </span>,<span class="blank _2"> </span>conteni<span class="blank"> </span>en<span class="blank"> </span>do<span class="blank _4"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>m<span class="blank"> </span>et<span class="blank"> </span>a<span class="blank"> </span>b<span class="blank _3"> </span>ol<span class="blank _3"> </span>it<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>co<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank _3"> </span>na<span class="blank _2"> </span>y<span class="blank _2"> </span>P<span class="ls19 v0">Cho.</span></div><div class="t m1 x14 h4 y11f ffb fs2 fc0 sc0 ls1e wsc0">-<span class="blank"> </span>Se<span class="blank"> </span>r<span class="blank _c"></span>ec<span class="blank _c"></span>ogen<span class="blank"> </span>los<span class="blank"> </span>so<span class="blank _c"></span>bre<span class="blank _c"></span>nadan<span class="blank _1c"></span>tes<span class="blank"> </span>en<span class="blank"> </span>tubos<span class="blank"> </span>de<span class="blank"> </span>15<span class="blank"> </span>ml<span class="blank"> </span>r<span class="blank _1c"></span>esist<span class="blank _c"></span>en<span class="blank _1c"></span>tes<span class="blank _9"> </span>a<span class="blank"> </span>disolv<span class="blank _1c"></span>en<span class="blank _c"></span>te<span class="blank _c"></span>s<span class="blank"> </span>org´<span class="blank _1b"></span><span class="ls8 wse3">anicos<span class="blank _1c"></span>.<span class="blank _15"> </span>Se<span class="blank _4"> </span>lav<span class="blank _1c"></span>an<span class="blank"> </span>los</span></div><div class="t m1 x1d h4 y120 ffb fs2 fc0 sc0 ls1e wse4">po<span class="blank _3"> </span>cillos<span class="blank _12"> </span>con<span class="blank"> </span>1<span class="blank"> </span>ml<span class="blank"> </span>de<span class="blank"> </span>TCA<span class="blank"> </span>al<span class="blank"> </span>16%<span class="blank"> </span>y<span class="blank"> </span>se<span class="blank"> </span>m<span class="lsf ws58">ezcl<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>muestra<span class="blank"> </span>s<span class="blank _4"> </span>anterio<span class="blank"> </span>res.</span></div><div class="t m1 x14 h4 y121 ffb fs2 fc0 sc0 ls46 wse5">-L<span class="blank _e"></span>a<span class="blank _e"></span>sc<span class="blank _a"></span>´<span class="blank _22"></span><span class="ls1c wsd2">elu<span class="blank _c"></span>las<span class="blank"> </span>\ufb01jadas<span class="blank"> </span>por<span class="blank _2"> </span>e<span class="blank _c"></span>l<span class="blank _2"> </span>TCA<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _2"> </span>los<span class="blank"> </span>p<span class="blank _3"> </span>ocillos<span class="blank _12"> </span>se<span class="blank"> </span>disue<span class="blank _c"></span>lv<span class="blank _c"></span>en<span class="blank"> </span>en<span class="blank"> </span>0,5<span class="blank"> </span>ml<span class="blank"> </span>de<span class="blank _2"> </span>hid<span class="blank _c"></span>r´<span class="blank _1b"></span><span class="ls8 ws4c">oxido<span class="blank"> </span>s´<span class="blank _1b"></span><span class="ls1c ws64">adic<span class="blank _1c"></span>o<span class="blank _2"> </span>0,5<span class="blank"> </span>N<span class="blank"> </span>y<span class="blank _2"> </span>se</span></span></span></div><div class="t m1 x1d h4 y122 ffb fs2 fc0 sc0 ls2d ws39">determina<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>radiactivi<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _f"> </span>incorp<span class="blank"> </span>o<span class="blank"> </span>rada<span class="blank _2"> </span>en<span class="blank _12"> </span>el<span class="blank _2"> </span>ma<span class="blank"> </span>terial<span class="blank _f"> </span>i<span class="blank"> </span>nsol<span class="blank"> </span>ubl<span class="blank"> </span>e<span class="blank _12"> </span>en<span class="blank _2"> </span>TCA<span class="blank _f"> </span>(fundam<span class="blank"> </span>entalmente<span class="blank _12"> </span>f<span class="blank"> </span>osfa<span class="blank"> </span>ti<span class="blank"> </span>di<span class="blank"> </span>l<span class="blank"> </span>co-</div><div class="t m1 x1d h4 y123 ffb fs2 fc0 sc0 ls1c ws88">lina)<span class="blank _12"> </span>por<span class="blank _f"> </span>m´<span class="blank _5"></span><span class="lsc ws38">eto<span class="blank _3"> </span>do<span class="blank"> </span>s<span class="blank _4"> </span>est´<span class="blank _5"></span><span class="lsf ws58">an<span class="blank"> </span>da<span class="blank"> </span>res<span class="blank _4"> </span>medi<span class="blank"> </span>a<span class="blank"> </span>nte<span class="blank _2"> </span>conta<span class="blank _27"> </span>je<span class="blank _2"> </span>centell<span class="blank"> </span>eo<span class="blank _4"> </span>l<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls14 ws40">\u0131qui<span class="blank"> </span>do<span class="blank _f"> </span>en<span class="blank _f"> </span>un<span class="blank _2"> </span>contador<span class="blank _f"> </span>de<span class="blank _2"> </span>emisiones<span class="blank _f"> </span><span class="ffd ls42">\u03b2</span><span class="ls9">.</span></span></span></span></div><div class="t m1 x14 h4 y124 ffb fs2 fc0 sc0 ls10 wsa6">-<span class="blank _8"> </span>Los<span class="blank _8"> </span>ext<span class="blank _c"></span>ract<span class="blank _c"></span>os<span class="blank _9"> </span>de<span class="blank _4"> </span>TCA<span class="blank _9"> </span>se<span class="blank _8"> </span>lav<span class="blank _1c"></span>an<span class="blank _2"> </span>con<span class="blank _9"> </span>cu<span class="blank _c"></span>atro<span class="blank _4"> </span>vol´<span class="blank _1b"></span><span class="lsc ws38">um<span class="blank _3"> </span>enes<span class="blank _9"> </span>de<span class="blank _8"> </span>´<span class="blank _6"></span><span class="lsf ws58">eter<span class="blank _7"> </span>satu<span class="blank"> </span>ra<span class="blank"> </span>do<span class="blank _9"> </span>en<span class="blank _9"> </span>a<span class="blank"> </span>g<span class="blank"> </span>ua<span class="blank"> </span>.<span class="blank _28"> </span>Al<span class="blank _9"> </span>mezcl<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _9"> </span>l<span class="blank _3"> </span>as</span></span></div><div class="t m1 x1d h4 y125 ffb fs2 fc0 sc0 ls43 wsd3">muestr<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>con<span class="blank _4"> </span>el<span class="blank _4"> </span>´<span class="blank _6"></span><span class="ls1e ws77">ete<span class="blank _c"></span>r,<span class="blank _8"> </span>se<span class="blank _4"> </span>forman<span class="blank"> </span>d<span class="blank _c"></span>os<span class="blank _4"> </span>fase<span class="blank _c"></span>s.<span class="blank _14"> </span>Se<span class="blank _4"> </span>agitan<span class="blank"> </span>en<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls15 ws6b">erg<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>m<span class="blank _3"> </span>ente<span class="blank _4"> </span>y<span class="blank _4"> </span>se<span class="blank _8"> </span>asp<span class="blank"> </span>i<span class="blank"> </span>ra<span class="blank _4"> </span>l<span class="blank _3"> </span>a<span class="blank _2"> </span>f<span class="blank"> </span>a<span class="blank"> </span>se<span class="blank _8"> </span>sup<span class="blank _3"> </span>erio<span class="blank"> </span>r,<span class="blank _9"> </span>que<span class="blank _4"> </span>se</span></span></div><div class="t m1 x1d h4 y126 ffb fs2 fc0 sc0 lsf ws8c">deshecha.<span class="blank _7"> </span>Se<span class="blank"> </span>repite<span class="blank"> </span>el<span class="blank"> </span>p<span class="blank _3"> </span>ro<span class="blank _3"> </span>ceso<span class="blank"> </span>tres<span class="blank"> </span>veces<span class="blank"> </span>m´<span class="blank _5"></span><span class="ls10 ws72">as.</span></div><div class="t m1 x1f h4 y127 ffb fs2 fc0 sc0 ls9">5</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf6" class="pf w0 h0" data-page-no="6"><div class="pc pc6 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x14 y128 w6 h24" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg6.png"><div class="t m1 x10 he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x0 hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x11 hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x11 hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x11 hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x11 hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x11 hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x11 hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x11 hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x11 hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x11 hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x11 hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x11 hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x13 h4 y51 ffb fs2 fc0 sc0 ls8 ws56">-<span class="blank"> </span>Las<span class="blank"> </span>mue<span class="blank _1c"></span>stras<span class="blank"> </span>se<span class="blank _f"> </span>neut<span class="blank _c"></span>raliz<span class="blank _c"></span>an<span class="blank"> </span>con<span class="blank"> </span>50<span class="blank _f"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls48 wse6">ld<span class="blank _19"></span>e<span class="blank _c"></span>t<span class="blank _e"></span>a<span class="blank _19"></span>m<span class="blank _e"></span>p<span class="blank _19"></span>´<span class="blank _1d"></span><span class="ls8 ws6d">on<span class="blank"> </span>T<span class="blank _1c"></span>ris<span class="blank"> </span>B<span class="blank _c"></span>ase<span class="blank"> </span>(pH<span class="blank"> </span>10)<span class="blank"> </span>y<span class="blank"> </span>se<span class="blank _f"> </span>agitan<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsf ws58">ergi<span class="blank"> </span>ca<span class="blank"> </span>m<span class="blank _3"> </span>ente<span class="blank _2"> </span>par<span class="blank"> </span>a</span></span></span></div><div class="t m1 x14 h4 yc6 ffb fs2 fc0 sc0 ls1c wse7">unifor<span class="blank _c"></span>mizar<span class="blank"> </span>la<span class="blank _f"> </span>solu<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="ls10 ws72">on.</span></div><div class="t m1 x13 h4 y8c ffb fs2 fc0 sc0 ls1c ws88">-<span class="blank _f"> </span>Se<span class="blank _f"> </span>tr<span class="blank _c"></span>ans<span class="blank _c"></span>\ufb01e<span class="blank _c"></span>re<span class="blank _c"></span>n<span class="blank _4"> </span>las<span class="blank _12"> </span>mue<span class="blank _1c"></span>stras<span class="blank _f"> </span>a<span class="blank _f"> </span>t<span class="blank _c"></span>ubos<span class="blank _f"> </span>eppen<span class="blank _c"></span>dorf<span class="blank _2"> </span>o<span class="blank _12"> </span>similare<span class="blank _c"></span>s<span class="blank _f"> </span>de<span class="blank _f"> </span>1.5<span class="blank _12"> </span>ml<span class="blank _f"> </span>y<span class="blank _f"> </span>se<span class="blank _f"> </span>se<span class="blank _c"></span>can<span class="blank _f"> </span>med<span class="blank _c"></span>ian<span class="blank _c"></span>te<span class="blank _12"> </span>lio\ufb01lizac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10">on</span></div><div class="t m1 x14 h4 yfb ffb fs2 fc0 sc0 lsf ws28">en<span class="blank _2"> </span>un<span class="blank _2"> </span>sistem<span class="blank"> </span>a<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>cen<span class="blank _c"></span>tri<span class="blank"> </span>f<span class="blank"> </span>ug<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws2b">on<span class="blank"> </span>al<span class="blank"> </span>v<span class="blank _c"></span>ac<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1c">\u0131o.</span></span></div><div class="t m1 x13 h4 yfc ffb fs2 fc0 sc0 lsc ws38">-<span class="blank _2"> </span>S<span class="blank"> </span>e<span class="blank _8"> </span>resu<span class="blank"> </span>sp<span class="blank _3"> </span>end<span class="blank"> </span>en<span class="blank _9"> </span>la<span class="blank _3"> </span>s<span class="blank _2"> </span>muestr<span class="blank"> </span>a<span class="blank _3"> </span>s<span class="blank _4"> </span>en<span class="blank _4"> </span>0<span class="blank"> </span>,<span class="blank _3"> </span>1<span class="blank _2"> </span>m<span class="blank _3"> </span>l<span class="blank _4"> </span>de<span class="blank _4"> </span>ag<span class="blank"> </span>u<span class="blank"> </span>a<span class="blank _4"> </span>desti<span class="blank _3"> </span>la<span class="blank _3"> </span>da<span class="blank _4"> </span>y<span class="blank _4"> </span>se<span class="blank _4"> </span>resuel<span class="blank"> </span>ven<span class="blank _8"> </span>al<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls1c ws88">\u0131c<span class="blank _c"></span>uotas<span class="blank _f"> </span>equ<span class="blank _c"></span>iv<span class="blank _1c"></span>alen<span class="blank _1c"></span>tes<span class="blank _2"> </span>por</span></div><div class="t m1 x14 h4 yfd ffb fs2 fc0 sc0 ls10 ws72">cr<span class="blank _c"></span>omatograf<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls8 ws1b">\u0131a<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _4"> </span>capa<span class="blank"> </span>\ufb01n<span class="blank _c"></span>a<span class="blank"> </span>utilizand<span class="blank _c"></span>o<span class="blank"> </span>plac<span class="blank _c"></span>as<span class="blank"> </span>de<span class="blank"> </span>ge<span class="blank _c"></span>l<span class="blank _4"> </span>de<span class="blank"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span>\u0131lice<span class="blank"> </span>c<span class="blank _c"></span>omo<span class="blank"> </span>soporte<span class="blank"> </span>y<span class="blank"> </span>como<span class="blank"> </span>fase<span class="blank"> </span>m´<span class="blank _1b"></span><span class="ls1e ws74">ovil<span class="blank"> </span>0,9%<span class="blank"> </span>clo-</span></span></div><div class="t m1 x14 h4 y129 ffb fs2 fc0 sc0 ls30 wsa9">ruro<span class="blank"> </span>s´<span class="blank _5"></span><span class="ls1b ws6c">odic<span class="blank _c"></span>o:met<span class="blank _c"></span>anol:h<span class="blank _c"></span>idr´<span class="blank _1b"></span><span class="ls8 wse8">oxid<span class="blank _c"></span>o<span class="blank"> </span>am´<span class="blank _1b"></span><span class="ls1c ws4f">onico<span class="blank _f"> </span>(<span class="blank _c"></span>50:70:1).<span class="blank _9"> </span>Al<span class="blank"> </span>mis<span class="blank _c"></span>mo<span class="blank"> </span>tie<span class="blank _c"></span>mpo,<span class="blank _2"> </span>se<span class="blank"> </span>res<span class="blank _c"></span>ue<span class="blank _c"></span>lv<span class="blank _c"></span>en<span class="blank _2"> </span>en<span class="blank"> </span>para<span class="blank _c"></span>lelo<span class="blank"> </span>e<span class="blank _c"></span>st<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls2f ws44">a<span class="blank _3"> </span>ndares</span></span></span></span></div><div class="t m1 x14 h4 y12a ffb fs2 fc0 sc0 ls31 ws7f">sint´<span class="blank _5"></span><span class="ls1c ws64">etic<span class="blank _1c"></span>os<span class="blank _2"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>colina<span class="blank"> </span>y<span class="blank"> </span>fosfocolin<span class="blank _c"></span>a<span class="blank"> </span>r<span class="blank _c"></span>adiac<span class="blank _c"></span>tiv<span class="blank _c"></span>os<span class="blank"> </span>como<span class="blank"> </span>in<span class="blank _c"></span>dicad<span class="blank _c"></span>ore<span class="blank _1c"></span>s.</span></div><div class="t m1 x13 h25 y12b ffb fs2 fc0 sc0 lsf ws58">-<span class="blank _2"> </span>S<span class="blank"> </span>e<span class="blank _4"> </span>i<span class="blank"> </span>denti<span class="blank"> </span>\ufb01ca<span class="blank"> </span>n<span class="blank _4"> </span>la<span class="blank"> </span>s<span class="blank _4"> </span>man<span class="blank"> </span>chas<span class="blank _2"> </span>r<span class="blank"> </span>a<span class="blank"> </span>di<span class="blank _3"> </span>acti<span class="blank _3"> </span>v<span class="blank _c"></span>as<span class="blank _2"> </span>co<span class="blank"> </span>rresp<span class="blank _3"> </span>o<span class="blank"> </span>nd<span class="blank"> </span>i<span class="blank"> </span>entes<span class="blank _9"> </span>a<span class="blank _2"> </span>col<span class="blank _3"> </span>in<span class="blank"> </span>a<span class="blank _2"> </span>y<span class="blank _4"> </span>P<span class="ls10 wsb4 v0">Cho<span class="blank"> </span>y<span class="blank _4"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>cuan<span class="blank _c"></span>ti\ufb01c<span class="blank _c"></span>an<span class="blank"> </span>median<span class="blank _1c"></span>te</span></div><div class="t m1 x14 h4 y12c ffb fs2 fc0 sc0 lsc ws48">centell<span class="blank"> </span>eo<span class="blank _2"> </span>l<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls2f ws49">\u0131quido<span class="blank _2"> </span>(se<span class="blank _f"> </span>ra<span class="blank"> </span>span<span class="blank _2"> </span>las<span class="blank _2"> </span>manchas<span class="blank _f"> </span>corresp<span class="blank"> </span>o<span class="blank _3"> </span>di<span class="blank"> </span>entes<span class="blank _4"> </span>tras<span class="blank _f"> </span>exp<span class="blank"> </span>o<span class="blank"> </span>si<span class="blank"> </span>ci´<span class="blank _5"></span>on<span class="blank _4"> </span>de<span class="blank _f"> </span>un<span class="blank _2"> </span>\ufb01l<span class="blank"> </span>m<span class="blank _2"> </span>se<span class="blank _c"></span>nsible<span class="blank _2"> </span>a<span class="blank _2"> </span>radi<span class="blank"> </span>a<span class="blank"> </span>ctivi<span class="blank"> </span>-</span></div><div class="t m1 x14 h4 y12d ffb fs2 fc0 sc0 ls2f ws16">dad)<span class="blank _f"> </span>o<span class="blank _2"> </span>sistemas<span class="blank _2"> </span>el<span class="blank"> </span>ectr´<span class="blank _1b"></span><span class="ls8 wse9">onicos<span class="blank"> </span>auto<span class="blank _c"></span>m´<span class="blank _1b"></span><span class="lsc ws57">a<span class="blank"> </span>t<span class="blank"> </span>i<span class="blank"> </span>co<span class="blank"> </span>s<span class="blank _f"> </span>co<span class="blank"> </span>nvenci<span class="blank"> </span>o<span class="blank"> </span>na<span class="blank"> </span>l<span class="blank _3"> </span>es<span class="blank _2"> </span>(di<span class="blank"> </span>recta<span class="blank"> </span>m<span class="blank _3"> </span>ente).</span></span></div><div class="t m1 x13 h26 y12e ffb fs2 fc0 sc0 ls2d ws39">-<span class="blank _2"> </span>El<span class="blank _f"> </span>efecto<span class="blank _2"> </span>de<span class="blank _2"> </span>cada<span class="blank _2"> </span>compuesto<span class="blank _f"> </span>ana<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>zado<span class="blank _2"> </span>sobre<span class="blank _2"> </span>la<span class="blank _f"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _1b"></span><span class="ls10 wsea">on<span class="blank _2"> </span>de<span class="blank _f"> </span>P<span class="blank"> </span><span class="ls2d ws39 v0">Cho<span class="blank _2"> </span>se<span class="blank _f"> </span>determina<span class="blank _2"> </span>m<span class="blank"> </span>ediante<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>nor-</span></span></div><div class="t m1 x14 h4 y12f ffb fs2 fc0 sc0 ls1c ws3a">malizac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls8 ws50">on<span class="blank _4"> </span>de<span class="blank _4"> </span>los<span class="blank _4"> </span>v<span class="blank _c"></span>alore<span class="blank _c"></span>s<span class="blank _8"> </span>de<span class="blank _8"> </span>radiac<span class="blank _c"></span>tividad<span class="blank _4"> </span>inc<span class="blank _c"></span>orporad<span class="blank _c"></span>os<span class="blank _8"> </span>en<span class="blank _8"> </span>el<span class="blank _8"> </span>metabolito<span class="blank _4"> </span>(c<span class="blank _c"></span>olina<span class="blank _4"> </span>o<span class="blank _8"> </span>P</span></div><div class="t m1 x27 h4 yd3 ffb fs2 fc0 sc0 lse wseb">Cho)<span class="blank"> </span>fre<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank _3"> </span>os</div><div class="t m1 x14 h4 yd4 ffb fs2 fc0 sc0 ls8 wsb6">niv<span class="blank _c"></span>ele<span class="blank _1c"></span>s<span class="blank"> </span>de<span class="blank"> </span>radiac<span class="blank _c"></span>tividad<span class="blank _12"> </span>incor<span class="blank _c"></span>porados<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>el<span class="blank"> </span>mater<span class="blank _c"></span>ial<span class="blank"> </span>insolu<span class="blank _c"></span>ble\u201d.</div><div class="t m1 x14 h4 y130 ffb fs2 fc0 sc0 ls1c wsec">3.3.-<span class="blank"> </span><span class="ffe ls1a wsba">Estrate<span class="blank _1c"></span>gia<span class="blank _12"> </span>de<span class="blank _f"> </span>inhibici<span class="blank"> </span>´<span class="blank _5"></span><span class="ls32 wsa8">on<span class="blank _f"> </span>de<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>util<span class="blank _3"> </span>izaci<span class="blank"> </span>´<span class="blank _5"></span>on<span class="blank _12"> </span>de<span class="blank _f"> </span>la<span class="blank _f"> </span>fosfor<span class="blank"> </span>i<span class="blank"> </span>l<span class="blank"> </span>colina<span class="blank _12"> </span>c<span class="blank _1c"></span>omo<span class="blank _f"> </span>se<span class="blank _1c"></span>gundo<span class="blank _f"> </span>m<span class="blank"> </span>ensaj<span class="blank"> </span>e<span class="blank"> </span>ro<span class="blank _12"> </span>de<span class="blank _f"> </span>pr<span class="blank _1c"></span>ol<span class="blank"> </span>i<span class="blank"> </span>f<span class="blank"> </span>eraci´<span class="blank _1b"></span>on</span></span></div><div class="t m1 x14 h4 y131 ffe fs2 fc0 sc0 ls1c ws40">c<span class="blank _1c"></span>elula<span class="blank _1c"></span>r</div><div class="t m1 x13 h4 y132 ffb fs2 fc0 sc0 ls1c ws7a">El<span class="blank"> </span>ens<span class="blank _1c"></span>ay<span class="blank _1c"></span>o<span class="blank _f"> </span>de<span class="blank"> </span>ac<span class="blank _c"></span>tividad<span class="blank"> </span>s<span class="blank _c"></span>obre<span class="blank"> </span>la<span class="blank"> </span>posible<span class="blank"> </span>u<span class="blank _c"></span>tiliz<span class="blank _c"></span>aci´<span class="blank _1b"></span>on<span class="blank"> </span>de<span class="blank"> </span>la<span class="blank"> </span>P</div><div class="t m1 x2c h4 y106 ffb fs2 fc0 sc0 ls10 ws86">Cho<span class="blank"> </span>en<span class="blank"> </span>rutas<span class="blank"> </span>alte<span class="blank _c"></span>rnativ<span class="blank _1"></span>as<span class="blank"> </span>a<span class="blank"> </span>la<span class="blank"> </span>s<span class="blank _1"></span>´<span class="blank _b"></span><span class="lsb wsa4">\u0131n<span class="blank _c"></span>te<span class="blank _c"></span>sis<span class="blank"> </span>de<span class="blank"> </span>PC</span></div><div class="t m1 x14 h4 y107 ffb fs2 fc0 sc0 ls14 wsab">se<span class="blank"> </span>deduc<span class="blank _c"></span>e<span class="blank _f"> </span>del<span class="blank _2"> </span>an´<span class="blank _1b"></span><span class="ls1c ws88">alisis<span class="blank _12"> </span>de<span class="blank _12"> </span>la<span class="blank _f"> </span>inc<span class="blank _1c"></span>orporaci´<span class="blank _1b"></span><span class="ls8 wsc9">on<span class="blank"> </span>de<span class="blank"> </span>colina<span class="blank"> </span>radiac<span class="blank _1c"></span>tiv<span class="blank _1c"></span>a<span class="blank _f"> </span>en<span class="blank"> </span>los<span class="blank"> </span>difer<span class="blank _c"></span>en<span class="blank _1c"></span>tes<span class="blank _f"> </span>in<span class="blank _1c"></span>terme<span class="blank _1c"></span>diarios<span class="blank"> </span>de<span class="blank _c"></span>l<span class="blank _f"> </span>proces<span class="blank _1c"></span>o</span></span></div><div class="t m1 x14 h4 y108 ffb fs2 fc0 sc0 ls14 ws40">biol<span class="blank"> </span>´<span class="blank _5"></span><span class="ls8 wse8">ogico<span class="blank"> </span>de<span class="blank"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls31 ws7f">\u0131<span class="blank"> </span>ntesis:</span></span></div><div class="t m1 x22 h4 y133 ffb fs2 fc0 sc0 ls3c wsae">12<span class="blank _b"></span>3</div><div class="t m1 x23 h4 y134 ffb fs2 fc0 sc0 lsb wsaf">co<span class="blank _c"></span>lina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _a"></span>\u2192<span class="blank"> </span><span class="ffb ls1c wsb1">fosforilc<span class="blank _1c"></span>olina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _e"></span>\u2192<span class="blank"> </span><span class="ffb lsb wsb2">CD<span class="blank _c"></span>P-c<span class="blank _1c"></span>olina<span class="blank"> </span><span class="fff ls9 wsb0">\u2212<span class="blank _a"></span>\u2192<span class="blank"> </span><span class="ffb ls1c ws3a">fosfatidilc<span class="blank _1c"></span>olina</span></span></span></span></span></span></div><div class="t m1 x24 h27 y135 ffb fs2 fc0 sc0 ls2f ws44">(P<span class="ls36 wsb3 v0">ch<span class="blank"> </span>o<span class="blank"> </span>)<span class="blank _24"> </span>(<span class="blank"> </span>P<span class="blank"> </span>C<span class="blank"> </span>)</span></div><div class="t m1 x14 h4 y136 ffb fs2 fc0 sc0 ls8 ws4c">dond<span class="blank _c"></span>e<span class="blank"> </span>1<span class="blank"> </span>corr<span class="blank _c"></span>es<span class="blank _1c"></span>p<span class="blank _3"> </span>onde<span class="blank"> </span>a<span class="blank _2"> </span>la<span class="blank _12"> </span>colina<span class="blank"> </span>qu<span class="blank _c"></span>inasa.<span class="blank _4"> </span>(E<span class="blank _c"></span>C<span class="blank"> </span>2.7.1.32),<span class="blank _12"> </span>2<span class="blank"> </span>a<span class="blank"> </span>la<span class="blank"> </span>citidilil-<span class="blank _c"></span>tran<span class="blank _c"></span>sfe<span class="blank _c"></span>ras<span class="blank _c"></span>a<span class="blank"> </span>(<span class="blank _c"></span>EC<span class="blank"> </span>2.7.7.15),<span class="blank _0"> </span>y<span class="blank"> </span>3<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank _3"> </span>a</div><div class="t m1 x14 h4 y137 ffb fs2 fc0 sc0 ls8 ws4c">colin<span class="blank _c"></span>o-fosfot<span class="blank _c"></span>rans<span class="blank _c"></span>fer<span class="blank _c"></span>asa<span class="blank _12"> </span>(E<span class="blank _c"></span>C<span class="blank"> </span>2.7.8.2).<span class="blank _2"> </span>En<span class="blank _2"> </span>c<span class="blank _c"></span>ondic<span class="blank _1c"></span>i<span class="blank _3"> </span>one<span class="blank _1c"></span>s<span class="blank"> </span>en<span class="blank"> </span>las<span class="blank"> </span>qu<span class="blank _c"></span>e<span class="blank"> </span>no<span class="blank"> </span>se<span class="blank"> </span>afec<span class="blank _1c"></span>ta<span class="blank"> </span>signi\ufb01c<span class="blank _1c"></span>ativ<span class="blank _1c"></span>amen<span class="blank _1c"></span>te<span class="blank"> </span>a<span class="blank"> </span>la<span class="blank"> </span>c<span class="blank _1c"></span>olina</div><div class="t m1 x14 h4 y138 ffb fs2 fc0 sc0 ls19 ws16">quinasa<span class="blank _4"> </span>p<span class="blank"> </span>ero<span class="blank _9"> </span>s<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls1c wsed">\u0131<span class="blank _9"> </span>a<span class="blank"> </span>la<span class="blank"> </span>pr<span class="blank _c"></span>olifer<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls8 wsd4">on<span class="blank"> </span>ce<span class="blank _1c"></span>lular,<span class="blank _9"> </span>sin<span class="blank"> </span>afec<span class="blank _c"></span>tar<span class="blank _8"> </span>a<span class="blank _9"> </span>la<span class="blank"> </span>cit<span class="blank _c"></span>idilil-t<span class="blank _c"></span>rans<span class="blank _c"></span>fer<span class="blank _c"></span>asa,<span class="blank"> </span>se<span class="blank"> </span>est<span class="blank _c"></span>ar<span class="blank _d"></span>´<span class="blank _a"></span><span class="lsf ws28">\u0131<span class="blank"> </span>a<span class="blank _7"> </span>ejerci<span class="blank"> </span>en<span class="blank"> </span>do<span class="blank _9"> </span>u<span class="blank"> </span>n</span></span></span></div><div class="t m1 x14 h4 y139 ffb fs2 fc0 sc0 ls1c ws64">efe<span class="blank _1c"></span>cto<span class="blank"> </span>inh<span class="blank _c"></span>ibidor<span class="blank _0"> </span>sobre<span class="blank"> </span>la<span class="blank _12"> </span>utiliz<span class="blank _1c"></span>aci´<span class="blank _1b"></span>on<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>la<span class="blank"> </span>P</div><div class="t m1 x12 h4 ye2 ffb fs2 fc0 sc0 ls6 ws80">Cho<span class="blank _f"> </span>en<span class="blank _f"> </span>rutas<span class="blank _12"> </span>m<span class="blank"> </span>i<span class="blank"> </span>tog´<span class="blank _5"></span><span class="ls8 ws24">enic<span class="blank _1c"></span>as,<span class="blank _f"> </span>c<span class="blank _c"></span>omo<span class="blank _f"> </span>se<span class="blank _f"> </span>ha<span class="blank _12"> </span>de<span class="blank _c"></span>sc<span class="blank _c"></span>rito<span class="blank _f"> </span>en<span class="blank _f"> </span>los<span class="blank _12"> </span>trab<span class="blank _c"></span>a<span class="blank"> </span>jos</span></div><div class="t m1 x14 h4 ye3 ffb fs2 fc0 sc0 ls2d ws39">previam<span class="blank"> </span>ente<span class="blank _2"> </span>publi<span class="blank"> </span>cados<span class="blank _2"> </span>p<span class="blank _3"> </span>or<span class="blank _4"> </span>alg<span class="blank"> </span>uno<span class="blank _2"> </span>de<span class="blank _4"> </span>los<span class="blank _4"> </span>inv<span class="blank _c"></span>en<span class="blank _c"></span>tores<span class="blank _4"> </span>(Carnero,<span class="blank _4"> </span>A.,<span class="blank _4"> </span>Cuadrado,<span class="blank _4"> </span>A.<span class="blank"> </span>,<span class="blank _4"> </span>del<span class="blank _4"> </span>P<span class="blank _c"></span>eso,<span class="blank _4"> </span>L.<span class="blank _2"> </span>y<span class="blank _4"> </span>Lacal,</div><div class="t m1 x14 h4 ye4 ffb fs2 fc0 sc0 ls10 ws8a">J.C.<span class="blank"> </span>1994.<span class="blank _16"> </span>Onc<span class="blank _c"></span>ogene<span class="blank"> </span>9:<span class="blank _14"> </span>1387-1395);<span class="blank"> </span>Jim´<span class="blank _1b"></span><span class="lsf ws58">enez,<span class="blank _9"> </span>B.<span class="blank"> </span>,<span class="blank _9"> </span>del<span class="blank _4"> </span>Peso,<span class="blank _9"> </span>L.<span class="blank"> </span>,<span class="blank _8"> </span>M<span class="blank"> </span>o<span class="blank"> </span>ntan<span class="blank"> </span>er,<span class="blank _8"> </span>S<span class="blank"> </span>.<span class="blank"> </span>,<span class="blank _9"> </span>Esteve,<span class="blank _9"> </span>P<span class="blank _1"></span>.<span class="blank _8"> </span>y<span class="blank _4"> </span>La<span class="blank"> </span>ca<span class="blank"> </span>l<span class="blank _3"> </span>,<span class="blank _8"> </span>J.<span class="blank"> </span>C<span class="blank"> </span>.</span></div><div class="t m1 x14 h4 ye5 ffb fs2 fc0 sc0 ls1e ws63">1995:<span class="blank _4"> </span>J.<span class="blank"> </span>Cell.<span class="blank _4"> </span>Bioch<span class="blank _c"></span>em.<span class="blank _4"> </span>57:<span class="blank _4"> </span>141149;<span class="blank"> </span>Cuadrado,<span class="blank"> </span>A.,<span class="blank"> </span>Carne<span class="blank _1c"></span>ro,<span class="blank _f"> </span>A.,<span class="blank _f"> </span>Dol\ufb01,<span class="blank"> </span>F<span class="blank _c"></span>.,<span class="blank"> </span>Jim´<span class="blank _1b"></span><span class="lse wsee">ene<span class="blank _1c"></span>z,<span class="blank"> </span>B.<span class="blank"> </span>y<span class="blank _12"> </span>Lacal<span class="blank _0"> </span>J.C.<span class="blank"> </span>1993.</span></div><div class="t m1 x14 h4 ye6 ffb fs2 fc0 sc0 lse ws47">Onc<span class="blank _1c"></span>ogene<span class="blank"> </span>8:<span class="blank _4"> </span>2959-2968).</div><div class="t m1 x14 h4 ye7 ffb fs2 fc0 sc0 ls1c wsef">3.3.1.-<span class="blank"> </span><span class="ffe ls2f ws6f">Ejemplo<span class="blank _2"> </span>de<span class="blank _2"> </span>ensayo<span class="blank _2"> </span>del<span class="blank _f"> </span>p<span class="blank _1c"></span>o<span class="blank _c"></span>der<span class="blank _2"> </span>antagonista<span class="blank _2"> </span>de<span class="blank _2"> </span>los<span class="blank _f"> </span>f´<span class="blank _5"></span><span class="ls1a wsba">armaco<span class="blank _c"></span>s<span class="blank _2"> </span>sobr<span class="blank _c"></span>e<span class="blank _f"> </span>la<span class="blank _2"> </span>activi<span class="blank"> </span>dad<span class="blank _2"> </span>mit<span class="blank"> </span>o<span class="blank _c"></span>g´<span class="blank _1b"></span><span class="ls8 wsf0">enic<span class="blank _1"></span>a<span class="blank"> </span>de<span class="blank"> </span>fosforil-</span></span></span></div><div class="t m1 x14 h4 y13a ffe fs2 fc0 sc0 ls30 ws14">c<span class="blank _1c"></span>ol<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _4"> </span>(PCho)</div><div class="t m1 x13 h4 y13b ffb fs2 fc0 sc0 lsf ws28">La<span class="blank"> </span>s<span class="blank _4"> </span>co<span class="blank"> </span>n<span class="blank"> </span>di<span class="blank"> </span>ci<span class="blank"> </span>o<span class="blank"> </span>nes<span class="blank _8"> </span>del<span class="blank _9"> </span>ensay<span class="blank _c"></span>o<span class="blank _8"> </span>so<span class="blank"> </span>n<span class="blank _8"> </span>sim<span class="blank"> </span>i<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>res<span class="blank _4"> </span>a<span class="blank _8"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>descri<span class="blank"> </span>ta<span class="blank"> </span>s<span class="blank _8"> </span>en<span class="blank _8"> </span>el<span class="blank _9"> </span>ensayo<span class="blank _4"> </span>de<span class="blank _9"> </span>coli<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _4"> </span>qui<span class="blank"> </span>n<span class="blank"> </span>asa<span class="blank _9"> </span><span class="ffe ls10 wsf1">in<span class="blank"> </span>vitr<span class="blank _1c"></span>o<span class="ffb ls47 wsf2">:e<span class="blank _1a"></span>n</span></span></div><div class="t m1 x14 h4 y13c ffb fs2 fc0 sc0 ls8 wsf3">n<span class="blank _c"></span>ue<span class="blank _c"></span>str<span class="blank _c"></span>o<span class="blank"> </span>ensa<span class="blank _1c"></span>yo<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>han<span class="blank"> </span>ut<span class="blank _c"></span>ilizado<span class="blank _4"> </span>tan<span class="blank _1c"></span>to<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls2f ws16">el<span class="blank"> </span>ul<span class="blank"> </span>as<span class="blank _9"> </span>de<span class="blank _8"> </span>rat´<span class="blank _5"></span><span class="ls8 ws4e">on<span class="blank"> </span>como<span class="blank"> </span>c<span class="blank _1c"></span>´<span class="blank _6"></span><span class="ls14 ws40">elulas<span class="blank _9"> </span>h<span class="blank _1c"></span>um<span class="blank"> </span>a<span class="blank"> </span>nas<span class="blank _9"> </span>disponi<span class="blank"> </span>bl<span class="blank"> </span>es<span class="blank _8"> </span>m<span class="blank"> </span>ediante<span class="blank _8"> </span>el</span></span></span></div><div class="t m1 x14 h4 y13d ffb fs2 fc0 sc0 ls3d ws4b">m´<span class="blank _6"></span><span class="lsf ws58">eto<span class="blank _3"> </span>do<span class="blank _2"> </span>de<span class="blank _2"> </span>cul<span class="blank"> </span>t<span class="blank"> </span>i<span class="blank"> </span>vos<span class="blank _f"> </span>i<span class="blank _3"> </span>nm<span class="blank"> </span>o<span class="blank"> </span>rt<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>za<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>s.<span class="blank _8"> </span>E<span class="blank"> </span>l<span class="blank _2"> </span>proto<span class="blank _3"> </span>co<span class="blank"> </span>l<span class="blank _3"> </span>o<span class="blank _2"> </span>es<span class="blank _2"> </span>como<span class="blank _2"> </span>si<span class="blank"> </span>g<span class="blank"> </span>u<span class="blank"> </span>e:</span></div><div class="t m1 x13 h4 y13e ffb fs2 fc0 sc0 ls2d ws49">\u201c-<span class="blank _2"> </span>Se<span class="blank _2"> </span>si<span class="blank"> </span>embran<span class="blank _2"> </span>c<span class="blank _c"></span>´<span class="blank _5"></span>el<span class="blank"> </span>ul<span class="blank"> </span>as<span class="blank _2"> </span>de<span class="blank _2"> </span>ra<span class="blank"> </span>t´<span class="blank _5"></span><span class="ls10 ws3d">on<span class="blank _2"> </span>o<span class="blank _2"> </span>h<span class="blank _c"></span>umanas<span class="blank"> </span>en<span class="blank _2"> </span>placas<span class="blank"> </span>de<span class="blank _2"> </span>pl´<span class="blank _1b"></span><span class="ls8 wsd1">astic<span class="blank _1c"></span>o<span class="blank"> </span>de<span class="blank"> </span>6<span class="blank"> </span>po<span class="blank _3"> </span>cillos<span class="blank _f"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>el<span class="blank"> </span>medio<span class="blank _f"> </span>ade<span class="blank _c"></span>cuad<span class="blank _c"></span>o</span></span></div><div class="t m1 x14 h4 y13f ffb fs2 fc0 sc0 lsf ws58">(DM<span class="blank"> </span>EM<span class="blank _2"> </span>o<span class="blank _f"> </span>equ<span class="blank"> </span>i<span class="blank"> </span>valente<span class="blank _f"> </span>sup<span class="blank"> </span>l<span class="blank"> </span>em<span class="blank"> </span>enta<span class="blank"> </span>do<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank _2"> </span>10%<span class="blank _2"> </span>suero<span class="blank _2"> </span>fet<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank _2"> </span>o<span class="blank _f"> </span>de<span class="blank _f"> </span>t<span class="blank"> </span>ernera<span class="blank _4"> </span>reci´<span class="blank _6"></span><span class="ls2d ws39">en<span class="blank _2"> </span>nacida<span class="blank"> </span>).<span class="blank _8"> </span>Se<span class="blank _2"> </span>a\u02dc<span class="blank _1b"></span><span class="ls1e ws84">naden<span class="blank"> </span>200.000</span></span></div><div class="t m1 x14 h4 y140 ffb fs2 fc0 sc0 ls36 ws6f">c´<span class="blank _6"></span><span class="ls8 ws50">elulas<span class="blank _12"> </span>por<span class="blank _12"> </span>p<span class="blank"> </span>o<span class="blank _3"> </span>cillo.<span class="blank _4"> </span>Se<span class="blank _0"> </span>hace<span class="blank _c"></span>n<span class="blank _f"> </span>cr<span class="blank _c"></span><span class="ls32 ws49">ecer<span class="blank _2"> </span>hasta<span class="blank _f"> </span>que<span class="blank _f"> </span>alca<span class="blank"> </span>nza<span class="blank"> </span>n<span class="blank _f"> </span>con\ufb02uencia<span class="blank _2"> </span>en<span class="blank _f"> </span>un<span class="blank _12"> </span>i<span class="blank _3"> </span>ncubador<span class="blank _f"> </span>con<span class="blank _f"> </span>5%<span class="blank _f"> </span>de<span class="blank _12"> </span>CO</span></span></div><div class="t m1 x1e h11 y141 ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls10 ws56 v3">,<span class="blank"> </span>95%</span></div><div class="t m1 x14 h10 y142 ffb fs2 fc0 sc0 ls8 ws61">aire<span class="blank"> </span>y<span class="blank"> </span>90%<span class="blank _2"> </span>h<span class="blank _1c"></span>umeda<span class="blank _c"></span>d,<span class="blank"> </span>a<span class="blank _2"> </span>37<span class="ff8 fs5 ls40 v4">\u25e6</span><span class="ls6 v0">C.</span></div><div class="t m1 x13 h4 y143 ffb fs2 fc0 sc0 ls2d ws39">-<span class="blank _12"> </span>No<span class="blank"> </span>rm<span class="blank"> </span>al<span class="blank"> </span>m<span class="blank"> </span>ente<span class="blank _12"> </span>a<span class="blank _f"> </span>la<span class="blank"> </span>s<span class="blank _f"> </span>48<span class="blank _12"> </span>ho<span class="blank"> </span>ras<span class="blank _f"> </span>se<span class="blank _2"> </span>alcanza<span class="blank _f"> </span>la<span class="blank _12"> </span>con\ufb02uencia<span class="blank"> </span>.<span class="blank _9"> </span>En<span class="blank _f"> </span>este<span class="blank _f"> </span>pun<span class="blank _c"></span>to<span class="blank _f"> </span>se<span class="blank _f"> </span>lav<span class="blank _1c"></span>a<span class="blank"> </span>n<span class="blank _12"> </span>la<span class="blank"> </span>s<span class="blank _f"> </span>pla<span class="blank"> </span>cas<span class="blank _f"> </span>con<span class="blank _f"> </span>tamp´<span class="blank _5"></span><span class="ls10">on</span></div><div class="t m1 x14 h4 y144 ffb fs2 fc0 sc0 ls2d ws4d">TD<span class="blank _9"> </span>(50<span class="blank _9"> </span>m<span class="blank"> </span>M<span class="blank _7"> </span>fosfa<span class="blank"> </span>to<span class="blank _9"> </span>s´<span class="blank _5"></span><span class="ls1e wsd6">odico,<span class="blank"> </span>150<span class="blank"> </span>mM<span class="blank _9"> </span>clorur<span class="blank _c"></span>o<span class="blank _9"> </span>s´<span class="blank _1b"></span><span class="ls8 wsd7">odico,<span class="blank"> </span>5<span class="blank"> </span>mM<span class="blank _9"> </span>c<span class="blank _c"></span>lorur<span class="blank _c"></span>o<span class="blank"> </span>pot´<span class="blank _1b"></span>asico,<span class="blank"> </span>pH<span class="blank"> </span>7,4)<span class="blank _8"> </span>y<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>a<span class="blank _3"> </span>\u02dc<span class="blank _1b"></span><span class="ls14 wsd8">naden<span class="blank"> </span>2</span></span></span></div><div class="t m1 x14 h4 y145 ffb fs2 fc0 sc0 ls1c ws7d">ml/po<span class="blank _3"> </span>c<span class="blank _c"></span>illo<span class="blank _f"> </span>de<span class="blank"> </span>med<span class="blank _c"></span>io<span class="blank"> </span>DM<span class="blank _c"></span>EM<span class="blank"> </span>s<span class="blank _c"></span>uple<span class="blank _c"></span>men<span class="blank _1c"></span>tado<span class="blank"> </span>c<span class="blank _1c"></span>on<span class="blank"> </span>0.5%<span class="blank _2"> </span>de<span class="blank"> </span>su<span class="blank _c"></span>er<span class="blank _c"></span>o<span class="blank"> </span>de<span class="blank"> </span>te<span class="blank _c"></span>rn<span class="blank _c"></span>er<span class="blank _c"></span>a.<span class="blank _16"> </span>Se<span class="blank _2"> </span>a\u02dc<span class="blank _1b"></span>nade<span class="blank _2"> </span>a<span class="blank"> </span>cad<span class="blank _c"></span>a<span class="blank"> </span>po<span class="blank _3"> </span>c<span class="blank _c"></span>illo<span class="blank"> </span>u<span class="blank _c"></span>na</div><div class="t m1 x14 h4 y146 ffb fs2 fc0 sc0 ls8 wsd9">can<span class="blank _1c"></span>tidad<span class="blank _2"> </span>c<span class="blank _c"></span>re<span class="blank _c"></span>cie<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _8"> </span>de<span class="blank _2"> </span>los<span class="blank"> </span>c<span class="blank _c"></span>ompue<span class="blank _c"></span>st<span class="blank _c"></span>os<span class="blank"> </span>a<span class="blank"> </span>analiz<span class="blank _c"></span>ar,<span class="blank"> </span>dis<span class="blank _1c"></span>ueltas<span class="blank _2"> </span>en<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>mismo<span class="blank _2"> </span>me<span class="blank _c"></span>dio,<span class="blank _2"> </span>de<span class="blank"> </span>forma<span class="blank _2"> </span>que<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>con<span class="blank _c"></span>siga</div><div class="t m1 x14 h4 y147 ffb fs2 fc0 sc0 lse ws45">una<span class="blank"> </span>c<span class="blank _c"></span>urv<span class="blank _1c"></span>a<span class="blank"> </span>cr<span class="blank _c"></span>ecie<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _4"> </span>que<span class="blank"> </span>abarqu<span class="blank _c"></span>e<span class="blank"> </span>un<span class="blank"> </span>rango<span class="blank"> </span>de<span class="blank"> </span>al<span class="blank _f"> </span>menos<span class="blank"> </span>1000<span class="blank"> </span>v<span class="blank _1c"></span><span class="lsc ws57">eces<span class="blank _4"> </span>la<span class="blank _2"> </span>co<span class="blank"> </span>ncentra<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _6"></span><span class="ls14 ws4d">on<span class="blank _2"> </span>m<span class="blank"> </span>enor<span class="blank _2"> </span>empl<span class="blank"> </span>eda,<span class="blank _2"> </span>que</span></span></div><div class="t m1 x14 h4 y148 ffb fs2 fc0 sc0 ls15 ws6b">estar´<span class="blank _5"></span><span class="ls8 ws4c">a<span class="blank _2"> </span>en<span class="blank"> </span>torno<span class="blank"> </span>a<span class="blank"> </span>0,1<span class="blank"> </span>micr<span class="blank _c"></span>omolar<span class="blank _12"> </span>(<span class="ffd ls9 wsc7">µ</span><span class="ls2d ws39">M).<span class="blank _2"> </span>Se<span class="blank _f"> </span>i<span class="blank"> </span>ncuba<span class="blank _2"> </span>durante<span class="blank _f"> </span>una<span class="blank _2"> </span>hora<span class="blank _2"> </span>en<span class="blank _f"> </span>condici<span class="blank"> </span>ones<span class="blank _2"> </span>es<span class="blank _c"></span>t´<span class="blank _5"></span>andard.</span></span></div><div class="t m1 x13 h4 y149 ffb fs2 fc0 sc0 ls44 wsdc">-S<span class="blank _a"></span>e<span class="blank"> </span>a<span class="blank _19"></span>\u02dc<span class="blank _21"></span><span class="ls14 wsdd">nade<span class="blank _c"></span>n<span class="blank _4"> </span>0,<span class="blank"> </span>5<span class="blank"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls1c ws88">Ci/po<span class="blank _3"> </span>cillo<span class="blank _f"> </span>de<span class="blank _2"> </span>(</span></span></div><div class="t m1 x2d h1f y14a ff5 fs5 fc0 sc0 ls3e wsde">14<span class="ffb fs2 ls2d ws39 v5">C)<span class="blank _4"> </span>m<span class="blank"> </span>etil<span class="blank"> </span>-col<span class="blank"> </span>i<span class="blank"> </span>na<span class="blank _2"> </span>como<span class="blank _2"> </span>precursor<span class="blank _8"> </span>radi<span class="blank"> </span>a<span class="blank"> </span>ctivo.<span class="blank _13"> </span>Se<span class="blank _2"> </span>i<span class="blank"> </span>ncuban<span class="blank _4"> </span>en<span class="blank _4"> </span>condi-</span></div><div class="t m1 x14 h10 y14b ffb fs2 fc0 sc0 lsc ws38">cio<span class="blank _3"> </span>nes<span class="blank _2"> </span>est´<span class="blank _5"></span><span class="ls14 wsb7">andar<span class="blank _2"> </span>de<span class="blank"> </span>CO<span class="ff5 fs5 ls41 v6">2</span><span class="ls10 ws59 v0">y<span class="blank _2"> </span>h<span class="blank _1c"></span>umedad<span class="blank"> </span>duran<span class="blank _1c"></span>te<span class="blank _2"> </span>12-14<span class="blank"> </span>horas<span class="blank _c"></span>.</span></span></div><div class="t m1 x13 h4 y14c ffb fs2 fc0 sc0 ls45 wsdf">-S<span class="blank _b"></span>el<span class="blank _a"></span>a<span class="blank _a"></span>v<span class="blank _b"></span>a<span class="blank _b"></span>nl<span class="blank _b"></span>a<span class="blank _a"></span>sc<span class="blank _b"></span>´<span class="blank _21"></span><span class="lsc ws57">el<span class="blank"> </span>u<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _4"> </span>co<span class="blank"> </span>n<span class="blank _4"> </span>ta<span class="blank"> </span>m<span class="blank"> </span>p<span class="blank"> </span>´<span class="blank _5"></span><span class="ls30 ws43">o<span class="blank"> </span>n<span class="blank _4"> </span>TD<span class="blank _8"> </span>y<span class="blank _4"> </span>se<span class="blank _4"> </span>pro<span class="blank _3"> </span>cesan<span class="blank _8"> </span>para<span class="blank _8"> </span>la<span class="blank _4"> </span>determi<span class="blank"> </span>na<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _4"> </span>del<span class="blank _4"> </span>contenido<span class="blank _4"> </span>ce<span class="blank _c"></span>lul<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _4"> </span>en</span></span></span></div><div class="t m1 x14 h28 y14d ffb fs2 fc0 sc0 ls9 wse0">P<span class="ls1f ws58 v0">Cho.<span class="blank _4"> </span>Se<span class="blank _f"> </span>a<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls1b ws76">nad<span class="blank _c"></span>e<span class="blank"> </span>1<span class="blank _12"> </span>ml/p<span class="blank _3"> </span>ocillo<span class="blank _0"> </span>de<span class="blank"> </span>u<span class="blank _c"></span>na<span class="blank"> </span>solu<span class="blank _c"></span>ci´<span class="blank _1b"></span><span class="ls10 ws60">on<span class="blank"> </span>acuos<span class="blank _1c"></span>a<span class="blank _f"> </span>de<span class="blank"> </span>´<span class="blank _1b"></span><span class="ls1e ws42">acido<span class="blank"> </span>tric<span class="blank _1c"></span>l<span class="blank _3"> </span>or<span class="blank _c"></span>oac<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls10 wsc9">etic<span class="blank _1c"></span>o<span class="blank _2"> </span>(<span class="blank _c"></span>TCA)<span class="blank"> </span>al<span class="blank"> </span>16%.<span class="blank _8"> </span>Se<span class="blank"> </span>man<span class="blank _c"></span>tiene</span></span></span></span></span></div><div class="t m1 x18 h4 y14e ffb fs2 fc0 sc0 ls9">6</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf7" class="pf w0 h0" data-page-no="7"><div class="pc pc7 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x2e y14f w7 h29" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg7.png"><div class="t m1 x1a he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x1b hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x1c hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x1c hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x1c hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x1c hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x1c hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x1c hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x1c hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x1c hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x1c hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x1c hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x1c hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x1d h4 y51 ffb fs2 fc0 sc0 ls38 wsf4">1h<span class="blank _b"></span>o<span class="blank _a"></span>r<span class="blank _a"></span>a<span class="blank"> </span>e<span class="blank _a"></span>nc<span class="blank _a"></span>´<span class="blank _21"></span><span class="ls1e ws1c">amara<span class="blank"> </span>fr<span class="blank _d"></span>´<span class="blank _a"></span><span class="lsb ws27">\u0131a<span class="blank"> </span>(4<span class="ff8 fs5 ls40 v4">\u25e6</span><span class="ls1c ws4d">C<span class="blank _c"></span>).<span class="blank _4"> </span>Est<span class="blank _c"></span>e<span class="blank _4"> </span>proce<span class="blank _c"></span>samie<span class="blank _c"></span>n<span class="blank _c"></span>to<span class="blank _4"> </span>\ufb01ja<span class="blank _2"> </span>las<span class="blank _4"> </span>c´<span class="blank _1b"></span><span class="ls8 ws8a">elulas<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>los<span class="blank"> </span>pocillos<span class="blank"> </span>y<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank _8"> </span>ext<span class="blank _c"></span>rae<span class="blank"> </span>el<span class="blank"> </span>mat<span class="blank _c"></span>erial</span></span></span></span></div><div class="t m1 x1d h4 yc6 ffb fs2 fc0 sc0 ls1c ws88">solu<span class="blank _c"></span>ble<span class="blank _12"> </span>en<span class="blank _2"> </span>el<span class="blank _12"> </span>TCA,<span class="blank _f"> </span>con<span class="blank _c"></span>te<span class="blank _c"></span>nien<span class="blank _c"></span>do<span class="blank _f"> </span>los<span class="blank _f"> </span>metabolitos<span class="blank _12"> </span>colina<span class="blank _12"> </span>y<span class="blank _2"> </span>P</div><div class="t m1 x6 h4 y150 ffb fs2 fc0 sc0 ls19">Cho.</div><div class="t m1 x14 h4 y151 ffb fs2 fc0 sc0 ls1e wsc0">-<span class="blank"> </span>Se<span class="blank"> </span>r<span class="blank _c"></span>ec<span class="blank _c"></span>ogen<span class="blank"> </span>los<span class="blank"> </span>so<span class="blank _c"></span>bre<span class="blank _c"></span>nadan<span class="blank _1c"></span>tes<span class="blank"> </span>en<span class="blank"> </span>tubos<span class="blank"> </span>de<span class="blank"> </span>15<span class="blank"> </span>ml<span class="blank"> </span>r<span class="blank _1c"></span>esist<span class="blank _c"></span>en<span class="blank _1c"></span>tes<span class="blank _9"> </span>a<span class="blank"> </span>disolv<span class="blank _1c"></span>en<span class="blank _c"></span>te<span class="blank _c"></span>s<span class="blank"> </span>org´<span class="blank _1b"></span><span class="ls8 wse3">anicos<span class="blank _1c"></span>.<span class="blank _15"> </span>Se<span class="blank _4"> </span>lav<span class="blank _1c"></span>an<span class="blank"> </span>los</span></div><div class="t m1 x1d h4 y152 ffb fs2 fc0 sc0 ls1e wse4">po<span class="blank _3"> </span>cillos<span class="blank _12"> </span>con<span class="blank"> </span>1<span class="blank"> </span>ml<span class="blank"> </span>de<span class="blank"> </span>TCA<span class="blank"> </span>al<span class="blank"> </span>16%<span class="blank"> </span>y<span class="blank"> </span>se<span class="blank"> </span>m<span class="lsf ws58">ezcl<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank _2"> </span>co<span class="blank"> </span>n<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _2"> </span>muestra<span class="blank"> </span>s<span class="blank _4"> </span>anterio<span class="blank"> </span>res.</span></div><div class="t m1 x14 h4 y153 ffb fs2 fc0 sc0 ls46 wse5">-L<span class="blank _e"></span>a<span class="blank _e"></span>sc<span class="blank _a"></span>´<span class="blank _22"></span><span class="ls1c wsd2">elu<span class="blank _c"></span>las<span class="blank"> </span>\ufb01jadas<span class="blank"> </span>por<span class="blank _2"> </span>e<span class="blank _c"></span>l<span class="blank _2"> </span>TCA<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank _2"> </span>los<span class="blank"> </span>p<span class="blank _3"> </span>ocillos<span class="blank _12"> </span>se<span class="blank"> </span>disue<span class="blank _c"></span>lv<span class="blank _c"></span>en<span class="blank"> </span>en<span class="blank"> </span>0,5<span class="blank"> </span>ml<span class="blank"> </span>de<span class="blank _2"> </span>hid<span class="blank _c"></span>r´<span class="blank _1b"></span><span class="ls8 ws4c">oxido<span class="blank"> </span>s´<span class="blank _1b"></span><span class="ls1c ws64">odic<span class="blank _1c"></span>o<span class="blank _2"> </span>0,5<span class="blank"> </span>N<span class="blank"> </span>y<span class="blank _2"> </span>se</span></span></span></div><div class="t m1 x1d h4 y154 ffb fs2 fc0 sc0 ls2d ws39">determina<span class="blank _12"> </span>la<span class="blank _f"> </span>radiactivi<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank _12"> </span>incorp<span class="blank _3"> </span>orada<span class="blank _12"> </span>a<span class="blank"> </span>l<span class="blank _f"> </span>material<span class="blank _0"> </span>i<span class="blank"> </span>nso<span class="blank"> </span>l<span class="blank"> </span>ubl<span class="blank"> </span>e<span class="blank _12"> </span>en<span class="blank _12"> </span>TCA<span class="blank _f"> </span>(fundamentalmente<span class="blank _0"> </span>fosfa<span class="blank"> </span>ti<span class="blank"> </span>di<span class="blank"> </span>l<span class="blank"> </span>coli<span class="blank"> </span>n<span class="blank"> </span>a)</div><div class="t m1 x1d h4 y155 ffb fs2 fc0 sc0 ls37 wsf5">por<span class="blank"> </span>m<span class="blank _1c"></span>´<span class="blank _5"></span><span class="lsc ws38">eto<span class="blank _3"> </span>do<span class="blank"> </span>s<span class="blank _2"> </span>est´<span class="blank _5"></span><span class="lsf ws58">a<span class="blank"> </span>n<span class="blank"> </span>da<span class="blank"> </span>res<span class="blank _4"> </span>medi<span class="blank"> </span>a<span class="blank"> </span>nte<span class="blank _2"> </span>conta<span class="blank _3"> </span>j<span class="blank _3"> </span>e<span class="blank _2"> </span>con<span class="blank _2"> </span>cen<span class="blank _c"></span>tel<span class="blank"> </span>l<span class="blank"> </span>eo<span class="blank _4"> </span>l<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls14 ws40">\u0131<span class="blank"> </span>qui<span class="blank"> </span>do<span class="blank _f"> </span>en<span class="blank _f"> </span>un<span class="blank _2"> </span>cont<span class="blank _c"></span>ador<span class="blank _2"> </span>de<span class="blank _2"> </span>emisiones<span class="blank _2"> </span><span class="ffd ls42">\u03b2</span><span class="ls9">.</span></span></span></span></div><div class="t m1 x14 h4 y156 ffb fs2 fc0 sc0 ls10 wsa6">-<span class="blank _8"> </span>Los<span class="blank _8"> </span>ext<span class="blank _c"></span>ract<span class="blank _c"></span>os<span class="blank _9"> </span>de<span class="blank _4"> </span>TCA<span class="blank _9"> </span>se<span class="blank _8"> </span>lav<span class="blank _1c"></span>an<span class="blank _2"> </span>con<span class="blank _9"> </span>cu<span class="blank _c"></span>atro<span class="blank _4"> </span>vol´<span class="blank _1b"></span><span class="lsc ws38">um<span class="blank _3"> </span>enes<span class="blank _9"> </span>de<span class="blank _8"> </span>´<span class="blank _6"></span><span class="lsf ws58">eter<span class="blank _7"> </span>satu<span class="blank"> </span>ra<span class="blank"> </span>do<span class="blank _9"> </span>en<span class="blank _9"> </span>a<span class="blank"> </span>g<span class="blank"> </span>ua<span class="blank"> </span>.<span class="blank _28"> </span>Al<span class="blank _9"> </span>mezcl<span class="blank"> </span>a<span class="blank"> </span>r<span class="blank _9"> </span>l<span class="blank _3"> </span>as</span></span></div><div class="t m1 x1d h4 y157 ffb fs2 fc0 sc0 ls43 wsd3">muestr<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _8"> </span>con<span class="blank _4"> </span>el<span class="blank _4"> </span>´<span class="blank _6"></span><span class="ls1e ws77">ete<span class="blank _c"></span>r,<span class="blank _8"> </span>se<span class="blank _4"> </span>forman<span class="blank"> </span>d<span class="blank _c"></span>os<span class="blank _4"> </span>fase<span class="blank _c"></span>s.<span class="blank _14"> </span>Se<span class="blank _4"> </span>agitan<span class="blank"> </span>en<span class="blank _1c"></span>´<span class="blank _5"></span><span class="ls15 ws6b">erg<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>m<span class="blank _3"> </span>ente<span class="blank _4"> </span>y<span class="blank _4"> </span>se<span class="blank _8"> </span>asp<span class="blank"> </span>i<span class="blank"> </span>ra<span class="blank _4"> </span>l<span class="blank _3"> </span>a<span class="blank _2"> </span>f<span class="blank"> </span>a<span class="blank"> </span>se<span class="blank _8"> </span>sup<span class="blank _3"> </span>erio<span class="blank"> </span>r,<span class="blank _9"> </span>que<span class="blank _4"> </span>se</span></span></div><div class="t m1 x1d h4 y158 ffb fs2 fc0 sc0 lsf ws8c">deshecha.<span class="blank _7"> </span>Se<span class="blank"> </span>repite<span class="blank"> </span>el<span class="blank"> </span>p<span class="blank _3"> </span>ro<span class="blank _3"> </span>ceso<span class="blank"> </span>tres<span class="blank"> </span>veces<span class="blank"> </span>m´<span class="blank _5"></span><span class="ls10 ws72">as.</span></div><div class="t m1 x14 h4 y159 ffb fs2 fc0 sc0 ls8 ws56">-<span class="blank"> </span>Las<span class="blank"> </span>mue<span class="blank _1c"></span>stras<span class="blank"> </span>se<span class="blank _f"> </span>neut<span class="blank _c"></span>raliz<span class="blank _c"></span>an<span class="blank"> </span>con<span class="blank"> </span>50<span class="blank _f"> </span><span class="ffd ls9 wsc7">µ</span><span class="ls48 wse6">ld<span class="blank _19"></span>e<span class="blank _c"></span>t<span class="blank _e"></span>a<span class="blank _19"></span>m<span class="blank _e"></span>p<span class="blank _19"></span>´<span class="blank _1d"></span><span class="ls8 ws95">on<span class="blank _f"> </span>T<span class="blank _1"></span>ris<span class="blank"> </span>Base<span class="blank"> </span>(pH<span class="blank _f"> </span>10)<span class="blank _f"> </span>y<span class="blank _f"> </span>se<span class="blank _f"> </span>agitan<span class="blank"> </span>en<span class="blank _1c"></span>´<span class="blank _5"></span><span class="lsf ws58">erg<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>m<span class="blank _3"> </span>ente<span class="blank _f"> </span>p<span class="blank"> </span>a<span class="blank"> </span>ra</span></span></span></div><div class="t m1 x1d h4 y15a ffb fs2 fc0 sc0 ls1c wse7">unifor<span class="blank _c"></span>mizar<span class="blank"> </span>la<span class="blank"> </span>soluc<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls10 ws72">on.</span></div><div class="t m1 x14 h4 y15b ffb fs2 fc0 sc0 ls1c ws73">-<span class="blank"> </span>Se<span class="blank"> </span>t<span class="blank _c"></span>rans<span class="blank _1c"></span>\ufb01er<span class="blank _c"></span>en<span class="blank"> </span>las<span class="blank _2"> </span>m<span class="blank _c"></span>ue<span class="blank _c"></span>st<span class="blank _c"></span>ras<span class="blank"> </span>a<span class="blank"> </span>tu<span class="blank _c"></span>bos<span class="blank"> </span>eppen<span class="blank _c"></span>dorf<span class="blank"> </span>o<span class="blank"> </span>similare<span class="blank _1c"></span>s<span class="blank"> </span>de<span class="blank"> </span>1.5<span class="blank _12"> </span>ml<span class="blank"> </span>y<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>se<span class="blank _c"></span>can<span class="blank"> </span>median<span class="blank _1c"></span>te<span class="blank"> </span>lio\ufb01<span class="blank _c"></span>lizac<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls10">on</span></div><div class="t m1 x1d h4 y15c ffb fs2 fc0 sc0 lsf ws28">en<span class="blank _2"> </span>un<span class="blank _2"> </span>sistem<span class="blank"> </span>a<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>cen<span class="blank _c"></span>tri<span class="blank"> </span>f<span class="blank"> </span>ug<span class="blank"> </span>a<span class="blank"> </span>ci<span class="blank"> </span>´<span class="blank _5"></span><span class="ls10 ws2b">on<span class="blank"> </span>al<span class="blank"> </span>v<span class="blank _c"></span>ac<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1c">\u0131o.</span></span></div><div class="t m1 x14 h4 y15d ffb fs2 fc0 sc0 lsc ws38">-<span class="blank _2"> </span>S<span class="blank"> </span>e<span class="blank _8"> </span>resu<span class="blank"> </span>sp<span class="blank _3"> </span>end<span class="blank"> </span>en<span class="blank _9"> </span>la<span class="blank _3"> </span>s<span class="blank _2"> </span>muestr<span class="blank"> </span>a<span class="blank _3"> </span>s<span class="blank _4"> </span>en<span class="blank _4"> </span>0<span class="blank"> </span>,<span class="blank _3"> </span>1<span class="blank _2"> </span>m<span class="blank _3"> </span>l<span class="blank _4"> </span>de<span class="blank _4"> </span>ag<span class="blank"> </span>u<span class="blank"> </span>a<span class="blank _4"> </span>desti<span class="blank _3"> </span>la<span class="blank _3"> </span>da<span class="blank _4"> </span>y<span class="blank _4"> </span>se<span class="blank _4"> </span>resuel<span class="blank"> </span>ven<span class="blank _8"> </span>al<span class="blank _1"></span>´<span class="blank _e"></span><span class="ls1c ws88">\u0131c<span class="blank _c"></span>uotas<span class="blank _f"> </span>equ<span class="blank _c"></span>iv<span class="blank _1c"></span>alen<span class="blank _1c"></span>tes<span class="blank _2"> </span>por</span></div><div class="t m1 x1d h4 y15e ffb fs2 fc0 sc0 ls10 ws72">cr<span class="blank _c"></span>omatograf<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls8 wse8">\u0131a<span class="blank _0"> </span>en<span class="blank"> </span>capa<span class="blank"> </span>\ufb01<span class="blank _c"></span>na<span class="blank"> </span>ut<span class="blank _c"></span>ilizand<span class="blank _c"></span>o<span class="blank"> </span>placas<span class="blank _0"> </span>de<span class="blank"> </span>ge<span class="blank _c"></span>l<span class="blank"> </span>de<span class="blank"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span>\u0131lice<span class="blank _0"> </span>como<span class="blank"> </span>soport<span class="blank _c"></span>e<span class="blank"> </span>y<span class="blank"> </span>como<span class="blank"> </span>fase<span class="blank"> </span>m´<span class="blank _1b"></span><span class="ls1e ws9e">ovil<span class="blank"> </span>0,9%<span class="blank _12"> </span>cloru<span class="blank _c"></span>ro</span></span></div><div class="t m1 x1d h4 y15f ffb fs2 fc0 sc0 ls31 ws80">s´<span class="blank _5"></span><span class="ls1b ws6c">odic<span class="blank _c"></span>o:met<span class="blank _c"></span>anol:h<span class="blank _c"></span>idr´<span class="blank _1b"></span><span class="ls8 wsdb">oxido<span class="blank"> </span>a<span class="blank _c"></span>m´<span class="blank _1b"></span><span class="ls1c ws7d">onico<span class="blank"> </span>(50:70:1)<span class="blank _c"></span>.<span class="blank _16"> </span>Se<span class="blank"> </span>res<span class="blank _1c"></span>uelv<span class="blank _1c"></span>en<span class="blank _9"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>parale<span class="blank _c"></span>lo<span class="blank"> </span>es<span class="blank _1c"></span>t´<span class="blank _1b"></span><span class="ls2f ws16">a<span class="blank"> </span>ndares<span class="blank _9"> </span>sint<span class="blank _c"></span>´<span class="blank _5"></span><span class="ls1b wsf6">etic<span class="blank _1c"></span>os<span class="blank _8"> </span>de<span class="blank"> </span>colina<span class="blank"> </span>y</span></span></span></span></span></div><div class="t m1 x1d h4 y160 ffb fs2 fc0 sc0 ls1c ws4d">fosfocolin<span class="blank _c"></span>a<span class="blank _12"> </span>radiact<span class="blank _c"></span>iv<span class="blank _c"></span>os<span class="blank _f"> </span>c<span class="blank _c"></span>omo<span class="blank _f"> </span>indic<span class="blank _1c"></span>adore<span class="blank _c"></span>s.</div><div class="t m1 x14 h2a y161 ffb fs2 fc0 sc0 lsf ws58">-<span class="blank _2"> </span>Se<span class="blank _2"> </span>identi<span class="blank"> </span>\ufb01ca<span class="blank"> </span>n<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _f"> </span>m<span class="blank _3"> </span>anchas<span class="blank _2"> </span>ra<span class="blank"> </span>di<span class="blank _3"> </span>acti<span class="blank _3"> </span>v<span class="blank _c"></span>as<span class="blank _f"> </span>co<span class="blank"> </span>rresp<span class="blank _3"> </span>o<span class="blank"> </span>nd<span class="blank"> </span>i<span class="blank"> </span>entes<span class="blank _8"> </span>a<span class="blank _f"> </span>co<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank _3"> </span>na<span class="blank"> </span>,<span class="blank _2"> </span>P<span class="ls1b wscd v0">Ch<span class="blank _c"></span>o<span class="blank"> </span>y<span class="blank"> </span>CDP-c<span class="blank _1c"></span>olina,<span class="blank _12"> </span>y<span class="blank"> </span>se<span class="blank"> </span>cuan<span class="blank _1c"></span>ti\ufb01-</span></div><div class="t m1 x1d h4 y162 ffb fs2 fc0 sc0 lsc ws48">can<span class="blank _f"> </span>m<span class="blank"> </span>edi<span class="blank"> </span>a<span class="blank"> </span>nte<span class="blank _f"> </span>centell<span class="blank"> </span>eo<span class="blank _2"> </span>l<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls2f ws16">\u0131q<span class="blank"> </span>ui<span class="blank"> </span>do<span class="blank _12"> </span>(se<span class="blank _2"> </span>raspan<span class="blank _f"> </span>las<span class="blank _f"> </span>manchas<span class="blank _f"> </span>correspo<span class="blank"> </span>di<span class="blank"> </span>entes<span class="blank _2"> </span>tras<span class="blank _f"> </span>exposi<span class="blank"> </span>ci´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _f"> </span>de<span class="blank _f"> </span>un<span class="blank _f"> </span>\ufb01l<span class="blank"> </span>m<span class="blank _12"> </span>sensible</span></span></div><div class="t m1 x1d h4 y163 ffb fs2 fc0 sc0 lsf ws28">a<span class="blank _f"> </span>ra<span class="blank"> </span>d<span class="blank"> </span>i<span class="blank"> </span>act<span class="blank"> </span>i<span class="blank"> </span>vi<span class="blank"> </span>d<span class="blank"> </span>ad<span class="blank"> </span>)<span class="blank _f"> </span>o<span class="blank _2"> </span>si<span class="blank"> </span>st<span class="blank"> </span>ema<span class="blank"> </span>s<span class="blank _2"> </span>elect<span class="blank"> </span>r´<span class="blank _5"></span><span class="ls8 wse9">onicos<span class="blank"> </span>aut<span class="blank _c"></span>om´<span class="blank _1b"></span><span class="lsc ws57">a<span class="blank"> </span>ti<span class="blank"> </span>co<span class="blank"> </span>s<span class="blank _2"> </span>convencion<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _2"> </span>(d<span class="blank"> </span>i<span class="blank"> </span>rect<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>ente).</span></span></div><div class="t m1 x14 h4 y164 ffb fs2 fc0 sc0 ls2d ws39">-<span class="blank _4"> </span>El<span class="blank _4"> </span>efecto<span class="blank _8"> </span>d<span class="blank"> </span>e<span class="blank _4"> </span>cada<span class="blank _8"> </span>com<span class="blank"> </span>puesto<span class="blank _4"> </span>a<span class="blank"> </span>nal<span class="blank"> </span>i<span class="blank"> </span>zado<span class="blank _4"> </span>sobre<span class="blank _8"> </span>la<span class="blank _4"> </span>pro<span class="blank _3"> </span>ducci´<span class="blank _1b"></span><span class="ls10 wsf7">on<span class="blank _9"> </span>de<span class="blank"> </span>P</span></div><div class="t m1 x2f h4 y165 ffb fs2 fc0 sc0 ls16 ws65">Cho<span class="blank"> </span>,<span class="blank _8"> </span>C<span class="blank"> </span>D<span class="blank"> </span>P-<span class="blank"> </span>co<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _4"> </span>y<span class="blank _8"> </span>PC<span class="blank _8"> </span>se<span class="blank _8"> </span>deter-</div><div class="t m1 x1d h4 y166 ffb fs2 fc0 sc0 ls1c ws7d">mina<span class="blank"> </span>me<span class="blank _c"></span>dian<span class="blank _1c"></span>te<span class="blank _8"> </span>la<span class="blank"> </span>normaliz<span class="blank _1c"></span>aci´<span class="blank _1b"></span><span class="ls1e wsf7">on<span class="blank"> </span>de<span class="blank _8"> </span>los<span class="blank"> </span>v<span class="blank _1c"></span>alores<span class="blank"> </span>de<span class="blank"> </span>radiac<span class="blank _c"></span>tividad<span class="blank"> </span>inc<span class="blank _c"></span>orporados<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank _9"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>metabolito<span class="blank"> </span>(P</span></div><div class="t m1 x30 h4 y167 ffb fs2 fc0 sc0 ls19">Cho,</div><div class="t m1 x1d h4 y168 ffb fs2 fc0 sc0 ls1c ws7d">CDP-<span class="blank _c"></span>colin<span class="blank _c"></span>a<span class="blank"> </span>y<span class="blank _4"> </span>PC)<span class="blank"> </span>fre<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank"> </span>a<span class="blank _8"> </span>los<span class="blank"> </span>nive<span class="blank _1c"></span>les<span class="blank _4"> </span>de<span class="blank"> </span>prote<span class="blank _d"></span>´<span class="blank _b"></span><span class="ls43 wsd3">\u0131<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _9"> </span>to<span class="blank"> </span>ta<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _8"> </span>en<span class="blank _9"> </span>cada<span class="blank _9"> </span>muestra<span class="blank"> </span>,<span class="blank _9"> </span>det<span class="blank"> </span>em<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank"> </span>do<span class="blank"> </span>s<span class="blank _9"> </span>p<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _8"> </span>m´<span class="blank _6"></span>eto<span class="blank _3"> </span>do<span class="blank"> </span>s</span></div><div class="t m1 x1d h4 y169 ffb fs2 fc0 sc0 lsf ws58">convencio<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>es<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>valo<span class="blank"> </span>ra<span class="blank"> </span>ci<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls2d ws47">on<span class="blank"> </span>de<span class="blank _2"> </span>prote<span class="blank _1"></span>´<span class="blank _b"></span><span class="ls8 wsf8">\u0131nas.<span class="blank"> </span>T<span class="blank _1"></span>am<span class="blank _c"></span>bi´<span class="blank _1b"></span><span class="lsf ws58">en<span class="blank _2"> </span>se<span class="blank _4"> </span>estab<span class="blank"> </span>l<span class="blank"> </span>ece<span class="blank _4"> </span>el<span class="blank _4"> </span>efecto<span class="blank _8"> </span>rel<span class="blank"> </span>a<span class="blank"> </span>ti<span class="blank"> </span>vo<span class="blank _4"> </span>sobre<span class="blank _4"> </span>los<span class="blank _4"> </span>enzim<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _4"> </span>co-</span></span></span></div><div class="t m1 x1d h4 y16a ffb fs2 fc0 sc0 ls1c ws4f">lina<span class="blank"> </span>qu<span class="blank _c"></span>inasa,<span class="blank"> </span>c<span class="blank _1c"></span>itidililtr<span class="blank _c"></span>ansfe<span class="blank _1c"></span>rasa<span class="blank"> </span>y<span class="blank"> </span>colin<span class="blank _c"></span>o-fosfo-t<span class="blank _c"></span>rans<span class="blank _1c"></span>feras<span class="blank _c"></span>a<span class="blank"> </span>med<span class="blank _c"></span>ian<span class="blank _c"></span>te<span class="blank"> </span>la<span class="blank"> </span>normaliz<span class="blank _1c"></span>aci´<span class="blank _1b"></span><span class="ls2d ws39">on<span class="blank _2"> </span>de<span class="blank _2"> </span>la<span class="blank _2"> </span>ra<span class="blank"> </span>di<span class="blank"> </span>a<span class="blank"> </span>ctivi<span class="blank"> </span>da<span class="blank"> </span>d</span></div><div class="t m1 x1d h4 y16b ffb fs2 fc0 sc0 ls8 ws4c">inc<span class="blank _c"></span>orporada<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank"> </span>cada<span class="blank"> </span>me<span class="blank _c"></span>tabolito<span class="blank"> </span>fr<span class="blank _1c"></span>en<span class="blank _c"></span>te<span class="blank _2"> </span>a<span class="blank _12"> </span>la<span class="blank"> </span>radiac<span class="blank _1c"></span>tividad<span class="blank _12"> </span>incor<span class="blank _c"></span>porada<span class="blank"> </span>en<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>mater<span class="blank _c"></span>ial<span class="blank"> </span>ins<span class="blank _1c"></span>oluble<span class="blank _12"> </span>(niv<span class="blank _1c"></span>eles<span class="blank"> </span>de</div><div class="t m1 x1d h4 y16c ffb fs2 fc0 sc0 ls32 ws49">PC)\u201d.</div><div class="t m1 x14 h4 y16d ffb fs2 fc0 sc0 lsf ws58">De<span class="blank _2"> </span>fo<span class="blank"> </span>rm<span class="blank"> </span>a<span class="blank _f"> </span>pa<span class="blank"> </span>r<span class="blank"> </span>a<span class="blank"> </span>l<span class="blank"> </span>el<span class="blank"> </span>a<span class="blank"> </span>,<span class="blank _2"> </span>se<span class="blank _2"> </span>crecen<span class="blank _2"> </span>cu<span class="blank"> </span>l<span class="blank"> </span>t<span class="blank"> </span>i<span class="blank"> </span>vos<span class="blank _2"> </span>celul<span class="blank"> </span>a<span class="blank"> </span>res<span class="blank _4"> </span>y<span class="blank _f"> </span>se<span class="blank _2"> </span>det<span class="blank"> </span>erm<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>a<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>capa<span class="blank"> </span>ci<span class="blank"> </span>d<span class="blank"> </span>a<span class="blank"> </span>d<span class="blank _2"> </span>de<span class="blank _2"> </span>cada<span class="blank _2"> </span>com<span class="blank"> </span>p<span class="blank"> </span>uest<span class="blank"> </span>o<span class="blank _4"> </span>de<span class="blank _2"> </span>in-</div><div class="t m1 x1d h4 y16e ffb fs2 fc0 sc0 ls14 ws40">hibir<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>s<span class="blank _1"></span>´<span class="blank _b"></span><span class="lsb ws76">\u0131n<span class="blank _c"></span>te<span class="blank _c"></span>sis<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _f"> </span>´<span class="blank _1b"></span><span class="ls1c ws8d">acid<span class="blank _c"></span>o<span class="blank"> </span>des<span class="blank _1c"></span>oxir<span class="blank _c"></span>ribon<span class="blank _c"></span>uc<span class="blank _c"></span>leic<span class="blank _c"></span>o<span class="blank _12"> </span>(ADN)<span class="blank"> </span>a<span class="blank"> </span>las<span class="blank"> </span>ve<span class="blank _1c"></span>int<span class="blank _c"></span>e<span class="blank"> </span>(20)<span class="blank"> </span>hor<span class="blank _c"></span>as<span class="blank"> </span>de<span class="blank _12"> </span>la<span class="blank"> </span>est<span class="blank _c"></span>imu<span class="blank _c"></span>laci´<span class="blank _1b"></span><span class="ls10 ws5e">on<span class="blank"> </span>con<span class="blank _0"> </span>factore<span class="blank _c"></span>s</span></span></span></div><div class="t m1 x1d h4 y16f ffb fs2 fc0 sc0 lsf ws28">de<span class="blank _f"> </span>crecim<span class="blank"> </span>i<span class="blank"> </span>ento<span class="blank _f"> </span>(Ji<span class="blank"> </span>m´<span class="blank _6"></span><span class="ls8 wsf9">ene<span class="blank _c"></span>z,<span class="blank"> </span>B.,<span class="blank"> </span>de<span class="blank _c"></span>l<span class="blank"> </span>P<span class="blank _c"></span>es<span class="blank _1c"></span>o,<span class="blank"> </span>L.,<span class="blank"> </span>Mon<span class="blank _c"></span>tane<span class="blank _c"></span>r,<span class="blank"> </span>S.,<span class="blank"> </span>E<span class="blank _1c"></span>stev<span class="blank _1c"></span>e,<span class="blank"> </span>P<span class="blank _1"></span>..<span class="blank _8"> </span>y<span class="blank"> </span>Lacal,<span class="blank _0"> </span>J.C.<span class="blank"> </span>1995:<span class="blank _2"> </span>J.<span class="blank"> </span>Cell.<span class="blank _4"> </span>Bioc<span class="blank _c"></span>hem.</span></div><div class="t m1 x1d h4 y170 ffb fs2 fc0 sc0 ls10 wsc9">57:<span class="blank _4"> </span>141-149).<span class="blank _2"> </span>El<span class="blank"> </span>an´<span class="blank _1b"></span><span class="ls1b ws9f">alisis<span class="blank"> </span>e<span class="blank _1c"></span>n<span class="blank"> </span>parale<span class="blank _c"></span>lo<span class="blank"> </span>del<span class="blank"> </span>efe<span class="blank _c"></span>ct<span class="blank _c"></span>o<span class="blank _12"> </span>sobr<span class="blank _c"></span>e<span class="blank"> </span>s<span class="blank _29"></span>´<span class="blank _b"></span><span class="lsb wsbc">\u0131nt<span class="blank _c"></span>es<span class="blank _1c"></span>is<span class="blank _12"> </span>de<span class="blank"> </span>PC<span class="blank"> </span>y<span class="blank _12"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls1b ws76">\u0131nt<span class="blank _c"></span>es<span class="blank _1c"></span>is<span class="blank"> </span>de<span class="blank"> </span>ADN<span class="blank _0"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>re<span class="blank _c"></span>aliza<span class="blank _0"> </span>utiliz<span class="blank _1c"></span>ando</span></span></span></div><div class="t m1 x1d h4 y171 ffb fs2 fc0 sc0 ls14 ws40">las<span class="blank _2"> </span>misma<span class="blank"> </span>s<span class="blank _f"> </span>concen<span class="blank _1c"></span>tra<span class="blank"> </span>cio<span class="blank"> </span>nes.<span class="blank _7"> </span>Lo<span class="blank"> </span>s<span class="blank _2"> </span>compuestos<span class="blank _2"> </span>que<span class="blank _2"> </span>inhi<span class="blank"> </span>ban<span class="blank _2"> </span>la<span class="blank _2"> </span>s<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls2f ws16">\u0131ntesis<span class="blank _2"> </span>de<span class="blank _f"> </span>AD<span class="blank"> </span>N<span class="blank _2"> </span>p<span class="blank _3"> </span>ero<span class="blank _2"> </span>de<span class="blank _2"> </span>forma<span class="blank _2"> </span>sig<span class="blank"> </span>ni<span class="blank"> </span>\ufb01cati<span class="blank"> </span>va</span></div><div class="t m1 x1d h4 y172 ffb fs2 fc0 sc0 ls2f ws16">no<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _8"> </span>de<span class="blank _8"> </span>PC<span class="blank _9"> </span>son<span class="blank _4"> </span>candida<span class="blank"> </span>to<span class="blank"> </span>s<span class="blank _8"> </span>a<span class="blank _8"> </span>esta<span class="blank _9"> </span>segunda<span class="blank _8"> </span>categor<span class="blank _29"></span>´<span class="blank _e"></span>\u0131<span class="blank"> </span>a<span class="blank _8"> </span>de<span class="blank _8"> </span>com<span class="blank"> </span>puestos<span class="blank _9"> </span>antitumora<span class="blank"> </span>l<span class="blank"> </span>es,<span class="blank _8"> </span>antiparasi<span class="blank"> </span>ta<span class="blank"> </span>ri<span class="blank"> </span>os<span class="blank _8"> </span>o</div><div class="t m1 x1d h4 y173 ffb fs2 fc0 sc0 ls10 ws65">an<span class="blank _c"></span>tif´<span class="blank _1b"></span><span class="ls14 ws40">ungi<span class="blank"> </span>cos.</span></div><div class="t m1 x1d h4 y174 ffb fs2 fc0 sc0 ls1c ws3c">4.-<span class="blank"> </span><span class="ff4 ls30 wsfa">Explicaci´<span class="blank _11"></span>o<span class="blank"> </span>n<span class="blank _4"> </span>d<span class="blank"> </span>e<span class="blank _4"> </span>la<span class="blank _4"> </span>invenci´<span class="blank _11"></span><span class="ls19">on</span></span></div><div class="t m1 x14 h4 y175 ffb fs2 fc0 sc0 ls2d ws39">Dentro<span class="blank _f"> </span>del<span class="blank _2"> </span>camp<span class="blank"> </span>o<span class="blank _2"> </span>de<span class="blank _2"> </span>la<span class="blank _f"> </span>inve<span class="blank _c"></span>nci´<span class="blank _5"></span><span class="ls14 ws40">on<span class="blank _f"> </span>mencionada<span class="blank"> </span>,<span class="blank _2"> </span>se<span class="blank _f"> </span>ha<span class="blank"> </span>n<span class="blank _2"> </span>dise\u02dc<span class="blank _1b"></span><span class="ls2d ws39">nado<span class="blank"> </span>,<span class="blank _2"> </span>sin<span class="blank _c"></span>tetizado<span class="blank _2"> </span>y<span class="blank _2"> </span>ens<span class="blank _c"></span>ay<span class="blank _c"></span>ado<span class="blank _f"> </span>g<span class="blank"> </span>ra<span class="blank"> </span>n<span class="blank _2"> </span>n´<span class="blank _1b"></span><span class="ls14 ws4d">um<span class="blank"> </span>ero</span></span></span></div><div class="t m1 x1d h4 y176 ffb fs2 fc0 sc0 ls9 wsfb">de<span class="blank _f"> </span>compuestos<span class="blank _2"> </span>qu<span class="blank _d"></span>´<span class="blank _e"></span><span class="lsf ws28">\u0131m<span class="blank"> </span>i<span class="blank"> </span>cos,<span class="blank _2"> </span>de<span class="blank _2"> </span>nuev<span class="blank _c"></span>a<span class="blank _2"> </span>estru<span class="blank"> </span>ctura<span class="blank _8"> </span>en<span class="blank _2"> </span>casi<span class="blank _2"> </span>su<span class="blank _4"> </span>tota<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>da<span class="blank"> </span>d<span class="blank"> </span>,<span class="blank _f"> </span>pa<span class="blank"> </span>ra<span class="blank _2"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>que<span class="blank _2"> </span>se<span class="blank _2"> </span>rei<span class="blank"> </span>vi<span class="blank"> </span>n<span class="blank"> </span>di<span class="blank"> </span>ca<span class="blank"> </span>n<span class="blank _2"> </span>su<span class="blank _2"> </span>d<span class="blank"> </span>i<span class="blank"> </span>se<span class="blank"> </span>\u02dc<span class="blank _1b"></span><span class="ls14 wsfc">no,</span></span></div><div class="t m1 x1d h4 y177 ffb fs2 fc0 sc0 ls49 wsfd">s´<span class="blank _18"></span><span class="ls1b ws73">\u0131n<span class="blank _c"></span>te<span class="blank _c"></span>sis<span class="blank"> </span>y<span class="blank"> </span>ut<span class="blank _c"></span>ilizac<span class="blank _c"></span>i´<span class="blank _1b"></span><span class="ls1e ws80">on<span class="blank _f"> </span>poster<span class="blank _c"></span>ior<span class="blank _2"> </span>en<span class="blank _f"> </span>el<span class="blank _f"> </span>´<span class="blank _1b"></span><span class="ls2f ws16">a<span class="blank"> </span>mbito<span class="blank _2"> </span>de<span class="blank _f"> </span>la<span class="blank _2"> </span>terap<span class="blank _c"></span>´<span class="blank _5"></span><span class="lsc ws38">eu<span class="blank"> </span>t<span class="blank"> </span>i<span class="blank _3"> </span>ca<span class="blank _2"> </span>q<span class="blank"> </span>u<span class="blank _1"></span>´<span class="blank _a"></span><span class="ls1c wsd2">\u0131mica;<span class="blank"> </span>asimis<span class="blank _1c"></span>mo,<span class="blank"> </span>uno<span class="blank _c"></span>s<span class="blank"> </span>po<span class="blank _3"> </span>cos<span class="blank"> </span>de<span class="blank"> </span>los<span class="blank"> </span>c<span class="blank _c"></span>om-</span></span></span></span></span></div><div class="t m1 x1d h4 y178 ffb fs2 fc0 sc0 lsf ws58">puesto<span class="blank"> </span>s<span class="blank _8"> </span>q<span class="blank"> </span>ue<span class="blank _4"> </span>se<span class="blank _8"> </span>descri<span class="blank"> </span>b<span class="blank _3"> </span>en,<span class="blank _9"> </span>al<span class="blank _4"> </span>esta<span class="blank"> </span>r<span class="blank _8"> </span>ya<span class="blank _2"> </span>p<span class="blank"> </span>ub<span class="blank"> </span>l<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>s,<span class="blank _8"> </span>se<span class="blank _4"> </span>fo<span class="blank"> </span>rmu<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>n<span class="blank _4"> </span>reiv<span class="blank"> </span>i<span class="blank"> </span>n<span class="blank"> </span>di<span class="blank"> </span>ca<span class="blank"> </span>ci<span class="blank _3"> </span>on<span class="blank"> </span>es<span class="blank _4"> </span>s´<span class="blank _5"></span><span class="ls15 ws6b">ol<span class="blank"> </span>o<span class="blank _4"> </span>sobre<span class="blank _8"> </span>su<span class="blank _4"> </span>p<span class="blank"> </span>o<span class="blank"> </span>si<span class="blank"> </span>b<span class="blank"> </span>l<span class="blank"> </span>e<span class="blank _4"> </span>uso</span></div><div class="t m1 x1d h4 y179 ffb fs2 fc0 sc0 ls8 ws49">como<span class="blank _12"> </span>agen<span class="blank _c"></span>te<span class="blank _c"></span>s<span class="blank _2"> </span>an<span class="blank _1c"></span>tineopl´<span class="blank _1b"></span>as<span class="blank _c"></span>icos<span class="blank _c"></span>,<span class="blank _f"> </span>an<span class="blank _1c"></span>tiparas<span class="blank _c"></span>itar<span class="blank _c"></span>ios<span class="blank _f"> </span>o<span class="blank _f"> </span>ant<span class="blank _c"></span>if<span class="blank"> </span>´<span class="blank _1b"></span><span class="ls14 ws40">ungicos.</span></div><div class="t m1 x14 h4 y17a ffb fs2 fc0 sc0 ls10 wsfe">Los<span class="blank _12"> </span>compu<span class="blank _c"></span>est<span class="blank _c"></span>os<span class="blank"> </span>pre<span class="blank _c"></span>parados<span class="blank _12"> </span>caen<span class="blank _12"> </span>den<span class="blank _1c"></span>tro<span class="blank"> </span>de<span class="blank _12"> </span>cuatr<span class="blank _c"></span>o<span class="blank"> </span>cate<span class="blank _1c"></span>gor<span class="blank _29"></span>´<span class="blank _a"></span><span class="ls31 ws46">\u0131<span class="blank"> </span>a<span class="blank"> </span>s<span class="blank _f"> </span>estructura<span class="blank"> </span>l<span class="blank"> </span>es,<span class="blank _4"> </span>qu<span class="blank"> </span>e<span class="blank _f"> </span>so<span class="blank"> </span>n<span class="blank _f"> </span>representada<span class="blank"> </span>s<span class="blank _4"> </span>po<span class="blank"> </span>r</span></div><div class="t m1 x1d h2b y17b ffb fs2 fc0 sc0 ls1c ws61">las<span class="blank"> </span>f´<span class="blank _1b"></span><span class="ls14 ws40">ormulas<span class="blank _f"> </span>gener<span class="blank _c"></span>ales<span class="blank _2"> </span>denominadas<span class="blank _f"> </span>\u201cF´<span class="blank _5"></span><span class="ls1c ws9a">orm<span class="blank _c"></span>ula<span class="blank"> </span>a<span class="ls10 ws56 v0">\u201d,<span class="blank"> </span>\u201cF´<span class="blank _1b"></span><span class="ls1c ws9a">orm<span class="blank _c"></span>ula<span class="blank"> </span>b<span class="ls10 ws2b">\u201d,<span class="blank"> </span>\u201cF<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls1c ws9a">ormu<span class="blank _c"></span>la<span class="blank"> </span>c<span class="ls4a wsff">\u201dy\u201c<span class="blank _19"></span>F<span class="blank _e"></span>´<span class="blank _22"></span><span class="ls1c ws9a">orm<span class="blank _1c"></span>ula<span class="blank"> </span>d<span class="ls8 ws50">\u201d,<span class="blank _12"> </span>res<span class="blank _c"></span>pect<span class="blank _c"></span>iv<span class="blank _1c"></span>a-</span></span></span></span></span></span></span></span></span></div><div class="t m1 x1d h4 y17c ffb fs2 fc0 sc0 lsf ws58">mente.<span class="blank _8"> </span>En<span class="blank _f"> </span>cad<span class="blank"> </span>a<span class="blank _f"> </span>caso,<span class="blank _f"> </span>se<span class="blank _f"> </span>expl<span class="blank"> </span>i<span class="blank"> </span>ca<span class="blank _f"> </span>adecu<span class="blank"> </span>a<span class="blank"> </span>da<span class="blank _f"> </span>y<span class="blank _12"> </span>co<span class="blank"> </span>nvenientem<span class="blank"> </span>ente<span class="blank _f"> </span>de<span class="blank _12"> </span>qu´<span class="blank _6"></span><span class="ls8 ws63">e<span class="blank"> </span>ele<span class="blank _c"></span>men<span class="blank _1c"></span>tos<span class="blank"> </span>es<span class="blank _c"></span>tru<span class="blank _c"></span>ct<span class="blank _c"></span>urale<span class="blank _1c"></span>s<span class="blank _f"> </span>cons<span class="blank _1c"></span>ta<span class="blank _f"> </span>c<span class="blank _c"></span>ada</span></div><div class="t m1 x1d h4 y17d ffb fs2 fc0 sc0 ls8 ws4c">f´<span class="blank _1b"></span>ormu<span class="blank _c"></span>la<span class="blank"> </span>gene<span class="blank _1c"></span>ral.<span class="blank _9"> </span>Por<span class="blank"> </span>otro<span class="blank _2"> </span>lado,<span class="blank"> </span>cad<span class="blank _c"></span>a<span class="blank _2"> </span>f´<span class="blank _1b"></span>ormu<span class="blank _c"></span>la<span class="blank"> </span>gene<span class="blank _1c"></span>ral<span class="blank _2"> </span>rep<span class="blank _c"></span>re<span class="blank _c"></span>se<span class="blank _c"></span>n<span class="blank _c"></span>ta<span class="blank _4"> </span>a<span class="blank _2"> </span>v<span class="blank _1"></span>arias<span class="blank"> </span>familias<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _2"> </span>n<span class="blank _1c"></span>uev<span class="blank _c"></span>os<span class="blank _2"> </span>c<span class="blank _c"></span>ompue<span class="blank _c"></span>st<span class="blank _c"></span>os</div><div class="t m1 x1d h4 y17e ffb fs2 fc0 sc0 ls1f ws100">qu<span class="blank _d"></span>´<span class="blank _a"></span><span class="ls8 wsd5">\u0131micos,<span class="blank _2"> </span>es<span class="blank _c"></span>tand<span class="blank _c"></span>o<span class="blank"> </span>car<span class="blank _c"></span>act<span class="blank _c"></span>er<span class="blank _c"></span>izada<span class="blank"> </span>cad<span class="blank _c"></span>a<span class="blank"> </span>familia<span class="blank _2"> </span>por<span class="blank"> </span>la<span class="blank _2"> </span>natu<span class="blank _c"></span>rale<span class="blank _c"></span>za<span class="blank"> </span>d<span class="blank _c"></span>el<span class="blank"> </span>gru<span class="blank _c"></span>po<span class="blank"> </span>que<span class="blank"> </span>de<span class="blank _1c"></span>nominamos<span class="blank _2"> </span>X<span class="blank"> </span>y<span class="blank"> </span>por<span class="blank"> </span>e<span class="blank _c"></span>l</span></div><div class="t m1 x1d h2c y17f ffb fs2 fc0 sc0 ls4b ws101">va<span class="blank"> </span>l<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _8"> </span>q<span class="blank"> </span>u<span class="blank"> </span>e<span class="blank _9"> </span>t<span class="blank"> </span>o<span class="blank"> </span>m<span class="blank"> </span>a<span class="blank _9"> </span>e<span class="blank"> </span>l<span class="blank _9"> </span>t<span class="blank _3"> </span>´<span class="blank _6"></span><span class="ls31 ws57">erm<span class="blank"> </span>i<span class="blank"> </span>no<span class="blank _9"> </span>n<span class="blank _9"> </span>(s´<span class="blank _5"></span><span class="ls8 ws98">olo<span class="blank"> </span>par<span class="blank _c"></span>a<span class="blank _8"> </span>las<span class="blank"> </span>familias<span class="blank _2"> </span>de<span class="blank _c"></span>nominad<span class="blank _c"></span>as<span class="blank"> </span>como<span class="blank"> </span>\u201cF´<span class="blank _1b"></span><span class="ls1c ws7d">orm<span class="blank _1c"></span>ula<span class="blank"> </span>a<span class="ls3a wsa1 v0">\u201dy\u201c<span class="blank _6"></span>F<span class="blank _b"></span>´<span class="blank _2a"></span><span class="ls1c ws102">orm<span class="blank _1c"></span>ula<span class="blank"> </span>b<span class="ls10 ws72">\u201d).</span></span></span></span></span></span></div><div class="t m1 x1d h4 yc1 ffb fs2 fc0 sc0 ls8 ws4c">Finalme<span class="blank _1c"></span>nte<span class="blank _1c"></span>,<span class="blank"> </span>den<span class="blank _1c"></span>tro<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>c<span class="blank _c"></span>ada<span class="blank"> </span>familia,<span class="blank _0"> </span>cad<span class="blank _c"></span>a<span class="blank"> </span>comp<span class="blank _c"></span>ues<span class="blank _1c"></span>to<span class="blank"> </span>conc<span class="blank _c"></span>re<span class="blank _c"></span>to<span class="blank"> </span>viene<span class="blank _12"> </span>det<span class="blank _c"></span>er<span class="blank _c"></span>minado<span class="blank"> </span>por<span class="blank"> </span>la<span class="blank _12"> </span>natu<span class="blank _c"></span>rale<span class="blank _c"></span>za<span class="blank"> </span>de<span class="blank"> </span>los</div><div class="t m1 x1d h14 yc2 ffb fs2 fc0 sc0 lsf ws58">susti<span class="blank"> </span>t<span class="blank"> </span>uyentes<span class="blank _4"> </span>que<span class="blank _4"> </span>se<span class="blank _4"> </span>representan<span class="blank _8"> </span>m<span class="blank"> </span>edi<span class="blank _3"> </span>ante<span class="blank _2"> </span>l<span class="blank"> </span>o<span class="blank _3"> </span>ca<span class="blank"> </span>l<span class="blank _3"> </span>iza<span class="blank"> </span>d<span class="blank"> </span>o<span class="blank"> </span>res<span class="blank _2"> </span>tal<span class="blank _3"> </span>es<span class="blank _4"> </span>com<span class="blank"> </span>o<span class="blank _2"> </span>Y,<span class="blank _4"> </span>Z,<span class="blank _4"> </span>R<span class="ff5 fs5 ls0 v6">1</span><span class="ls4c v0">,R</span></div><div class="t m1 x31 h11 y180 ff5 fs5 fc0 sc0 ls41">2<span class="ffb fs2 ls4d v3">yR</span></div><div class="t m1 x32 h11 y180 ff5 fs5 fc0 sc0 ls0">3<span class="ffb fs2 ls1e wsf0 v3">.<span class="blank _7"> </span>Los<span class="blank"> </span>compu<span class="blank _c"></span>es<span class="blank _c"></span>tos</span></div><div class="t m1 x1d h4 y181 ffb fs2 fc0 sc0 lsf ws58">p<span class="blank"> </span>erten<span class="blank"> </span>eci<span class="blank"> </span>entes<span class="blank _8"> </span>a<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>pri<span class="blank"> </span>m<span class="blank"> </span>era<span class="blank _2"> </span>ca<span class="blank"> </span>t<span class="blank"> </span>eg<span class="blank"> </span>o<span class="blank"> </span>r<span class="blank _29"></span>´<span class="blank _e"></span><span class="ls1a ws4b">\u0131a<span class="blank _2"> </span>estructural<span class="blank _2"> </span>se<span class="blank _2"> </span>represen<span class="blank _1c"></span>ta<span class="blank"> </span>n<span class="blank _4"> </span>p<span class="blank _3"> </span>or<span class="blank _2"> </span>la<span class="blank _f"> </span>\u201c<span class="blank"> </span>F´<span class="blank _5"></span><span class="ls1c ws64">orm<span class="blank _c"></span>ula<span class="blank"> </span>a</span></span></div><div class="t m1 x33 h4 y182 ffb fs2 fc0 sc0 ls9">\u201d</div><div class="t m1 x1f h4 y183 ffb fs2 fc0 sc0 ls9">7</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf8" class="pf w0 h0" data-page-no="8"><div class="pc pc8 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x34 y184 w8 h2d" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg8.png"><div class="t m1 x10 he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x0 hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x11 hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x11 hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x11 hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x11 hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x11 hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x11 hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x11 hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x11 hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x11 hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x11 hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x11 hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x14 h4 y185 ffb fs2 fc0 sc0 ls2d ws39">en<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _2"> </span>que<span class="blank _f"> </span>n<span class="blank _2"> </span>puede<span class="blank _f"> </span>ser<span class="blank _f"> </span>0<span class="blank"> </span>,<span class="blank _2"> </span>1,<span class="blank _2"> </span>2,<span class="blank _f"> </span>3<span class="blank"> </span>,<span class="blank _2"> </span>etc<span class="blank _c"></span>.<span class="blank _9"> </span>y<span class="blank _f"> </span>el<span class="blank _2"> </span>grup<span class="blank"> </span>o<span class="blank _2"> </span>X<span class="blank _2"> </span>puede<span class="blank _f"> </span>ser<span class="blank _2"> </span>cualquiera<span class="blank _2"> </span>de<span class="blank _f"> </span>l<span class="blank"> </span>os<span class="blank _f"> </span>elem<span class="blank"> </span>entos<span class="blank _2"> </span>es<span class="blank _c"></span>tructurales<span class="blank _4"> </span>A,</div><div class="t m1 x14 h4 y186 ffb fs2 fc0 sc0 lsf ws103">B,<span class="blank _f"> </span>C<span class="blank _2"> </span>y<span class="blank _2"> </span>D<span class="blank"> </span>:</div><div class="t m1 x14 h4 y187 ffb fs2 fc0 sc0 ls1e wsd9">sie<span class="blank _c"></span>ndo,<span class="blank"> </span>en<span class="blank _4"> </span>cada<span class="blank"> </span>caso,<span class="blank _8"> </span>Y<span class="blank"> </span>sus<span class="blank _c"></span>tituy<span class="blank _1c"></span>en<span class="blank _1c"></span>tes<span class="blank _8"> </span>tales<span class="blank"> </span>c<span class="blank _c"></span>omo:<span class="blank _16"> </span>-H,<span class="blank"> </span>CH</div><div class="t m1 x35 h11 y188 ff5 fs5 fc0 sc0 ls2b">3<span class="ffb fs2 lsb wsc5 v3">,CH</span></div><div class="t m1 x36 h11 y188 ff5 fs5 fc0 sc0 ls0">2<span class="ffb fs2 ls32 ws104 v3">OH,<span class="blank"> </span>-CO-C<span class="blank _3"> </span>H</span><span class="ls2b">3<span class="ffb fs2 ls4e ws105 v3">,-<span class="blank _b"></span>C<span class="blank _b"></span>N<span class="blank _6"></span>,-<span class="blank _b"></span>N<span class="blank _b"></span>H</span></span></div><div class="t m1 x37 h11 y188 ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls2d ws8b v3">,<span class="blank"> </span>-N(CH</span>3<span class="ffb fs2 ls9 wse0 v3">)</span>2<span class="ffb fs2 ls9 v3">,</span></div><div class="t m1 x14 h4 y189 ffb fs2 fc0 sc0 ls14 ws40">pirrol<span class="blank"> </span>i<span class="blank"> </span>di<span class="blank"> </span>no<span class="blank"> </span>,<span class="blank _12"> </span>pi<span class="blank"> </span>p<span class="blank _3"> </span>eridino,<span class="blank _2"> </span>perhidroa<span class="blank"> </span>zepino,<span class="blank _2"> </span>-OH,<span class="blank _2"> </span>-O-CO-C</div><div class="t m1 x38 h11 y18a ff5 fs5 fc0 sc0 ls3e wsde">15<span class="ffb fs2 ls9 wse0 v3">H</span>31<span class="blank"> </span><span class="ffb fs2 ls4f ws106 v3">,e<span class="blank _e"></span>t<span class="blank _e"></span>c<span class="blank _a"></span>.</span></div><div class="t m1 x13 h4 y18b ffb fs2 fc0 sc0 ls1e ws55">En<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>caso<span class="blank"> </span>par<span class="blank _c"></span>tic<span class="blank _c"></span>ular<span class="blank"> </span>que<span class="blank"> </span>se<span class="blank"> </span>p<span class="blank _c"></span>re<span class="blank _c"></span>se<span class="blank _c"></span>n<span class="blank _c"></span>ta<span class="blank _4"> </span>c<span class="blank _c"></span>uando<span class="blank"> </span>n<span class="blank"> </span>toma<span class="blank _12"> </span>el<span class="blank"> </span>v<span class="blank _1c"></span>alor<span class="blank"> </span>2,<span class="blank"> </span>ad<span class="blank _c"></span>em´<span class="blank _1b"></span><span class="ls14 ws40">as<span class="blank _2"> </span>de<span class="blank _2"> </span>los<span class="blank _f"> </span>compuestos<span class="blank _2"> </span>que<span class="blank _2"> </span>re<span class="blank _c"></span>sul-</span></div><div class="t m1 x14 h4 y18c ffb fs2 fc0 sc0 ls2f ws16">tan<span class="blank _4"> </span>de<span class="blank _8"> </span>la<span class="blank _4"> </span>\u201c<span class="blank"> </span>F´<span class="blank _5"></span><span class="ls1c ws7d">orm<span class="blank _c"></span>ula<span class="blank"> </span>a</span></div><div class="t m1 x39 h4 y18d ffb fs2 fc0 sc0 ls2f ws16">\u201d,<span class="blank _8"> </span>se<span class="blank _8"> </span>han<span class="blank _8"> </span>preparado<span class="blank _8"> </span>ta<span class="blank"> </span>mbi´<span class="blank _5"></span>en<span class="blank _4"> </span>los<span class="blank _4"> </span>q<span class="blank"> </span>ue<span class="blank _4"> </span>deri<span class="blank"> </span>v<span class="blank _c"></span>an<span class="blank _8"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>estructura<span class="blank _9"> </span>de<span class="blank _4"> </span>cis-<span class="blank _8"> </span>(Z<span class="ls50 ws107">)yt<span class="blank _a"></span>r<span class="blank _b"></span>a<span class="blank _b"></span>n<span class="blank _b"></span>s</span></div><div class="t m1 x14 h23 y18e ffb fs2 fc0 sc0 ls2f ws44">(E<span class="ls1c ws73 v0">)-e<span class="blank _1c"></span>stilbenos<span class="blank"> </span>pro<span class="blank _1c"></span>visto<span class="blank _c"></span>s<span class="blank"> </span>de<span class="blank"> </span>los<span class="blank"> </span>s<span class="blank _1c"></span>ustit<span class="blank _c"></span>uy<span class="blank _c"></span>en<span class="blank _1c"></span>te<span class="blank _c"></span>s<span class="blank _2"> </span>X<span class="blank _2"> </span>(modalidad<span class="blank _c"></span>es<span class="blank _12"> </span>A,<span class="blank"> </span>B,<span class="blank"> </span>C<span class="blank"> </span>y<span class="blank _2"> </span>D)<span class="blank"> </span>e<span class="blank"> </span>Y<span class="blank"> </span>pre<span class="blank _1c"></span>viamen<span class="blank _1c"></span>te<span class="blank"> </span>indic<span class="blank _c"></span>ados<span class="blank _c"></span>.</span></div><div class="t m1 x13 h2e y18f ffb fs2 fc0 sc0 lsf ws58">Al<span class="blank"> </span>g<span class="blank"> </span>un<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>ej<span class="blank"> </span>em<span class="blank _3"> </span>pl<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _2"> </span>co<span class="blank"> </span>m<span class="blank"> </span>p<span class="blank"> </span>u<span class="blank"> </span>esto<span class="blank"> </span>s<span class="blank _4"> </span>p<span class="blank _3"> </span>erteneci<span class="blank"> </span>entes<span class="blank _9"> </span>a<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>\u201cF´<span class="blank _5"></span><span class="ls1c ws64">ormu<span class="blank _c"></span>la<span class="blank"> </span>a<span class="ls1e wse1 v0">\u201d<span class="blank"> </span>se<span class="blank"> </span>re<span class="blank _1c"></span>pres<span class="blank _c"></span>en<span class="blank _1c"></span>tan<span class="blank _4"> </span>a<span class="blank"> </span>con<span class="blank _1c"></span>tinu<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls10 wsca">on<span class="blank"> </span>con</span></span></span></div><div class="t m1 x14 h4 y190 ffb fs2 fc0 sc0 lsb ws108">la<span class="blank"> </span>in<span class="blank _1c"></span>tenc<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls1e ws84">on<span class="blank"> </span>de<span class="blank _f"> </span>mostrar</span></div><div class="t m1 x14 h4 y191 ffb fs2 fc0 sc0 ls2f ws16">alg<span class="blank"> </span>una<span class="blank"> </span>s<span class="blank _f"> </span>estructuras<span class="blank _2"> </span>com<span class="blank"> </span>pl<span class="blank"> </span>etas.</div><div class="t m1 x13 h4 y192 ffb fs2 fc0 sc0 ls1f wsc0">La<span class="blank"> </span>primera<span class="blank"> </span>de<span class="blank"> </span>l<span class="blank _3"> </span>as<span class="blank"> </span>mol´<span class="blank _5"></span><span class="ls1e ws97">ec<span class="blank _c"></span>ulas<span class="blank _4"> </span>most<span class="blank _c"></span>radas<span class="blank"> </span>(<span class="blank _c"></span>GRQF<span class="blank _c"></span>-JCR795b<span class="blank _c"></span>,<span class="blank"> </span>como<span class="blank"> </span>n<span class="blank _c"></span>omb<span class="blank _c"></span>re<span class="blank"> </span>de<span class="blank"> </span>in<span class="blank _1c"></span>ve<span class="blank _c"></span>n<span class="blank _c"></span>tor)<span class="blank"> </span>s<span class="blank _c"></span>e<span class="blank"> </span>den<span class="blank _c"></span>omina</span></div><div class="t m1 x14 h4 y193 ffb fs2 fc0 sc0 lsf wsd3">sist<span class="blank"> </span>em<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1c ws109">aticame<span class="blank _1c"></span>nt<span class="blank _c"></span>e<span class="blank"> </span>\u201cdibr<span class="blank _c"></span>omu<span class="blank _c"></span>ro<span class="blank _8"> </span>de<span class="blank"> </span>1,1\u2019-(Bibe<span class="blank _c"></span>ncilo-<span class="blank _c"></span>4,4\u2019di<span class="blank _c"></span>met<span class="blank _c"></span>il)bi<span class="blank _c"></span>s[4-(<span class="blank _c"></span>N</span></div><div class="t m1 x3a h4 y194 ffb fs2 fc0 sc0 lsb wsc5">,N<span class="ls1b ws7b">-d<span class="blank _c"></span>imet<span class="blank _c"></span>ilamino)p<span class="blank _c"></span>irid<span class="blank _c"></span>in<span class="blank _c"></span>io]<span class="blank"> </span>y<span class="blank _9"> </span>es<span class="blank _9"> </span>un</span></div><div class="t m1 x14 h23 y195 ffb fs2 fc0 sc0 lsc ws38">ejem<span class="blank _3"> </span>pl<span class="blank"> </span>o<span class="blank _f"> </span>de<span class="blank _f"> </span>mo<span class="blank _3"> </span>l´<span class="blank _5"></span>ecu<span class="blank"> </span>l<span class="blank _3"> </span>a<span class="blank _f"> </span>integ<span class="blank"> </span>ra<span class="blank _3"> </span>da<span class="blank _f"> </span>dentro<span class="blank _2"> </span>de<span class="blank _12"> </span>l<span class="blank _3"> </span>a<span class="blank _f"> </span>\u201cF´<span class="blank _5"></span><span class="ls1c ws8d">ormu<span class="blank _c"></span>la<span class="blank"> </span>a<span class="ls2d ws39 v0">\u201d<span class="blank _12"> </span>pa<span class="blank"> </span>ra<span class="blank _f"> </span>la<span class="blank _f"> </span>que<span class="blank _12"> </span>n=2,<span class="blank _2"> </span>X<span class="blank _12"> </span>es<span class="blank _f"> </span>el<span class="blank _12"> </span>g<span class="blank"> </span>rup<span class="blank"> </span>o<span class="blank _2"> </span>piridi<span class="blank"> </span>ni<span class="blank"> </span>o<span class="blank"> </span>-1<span class="blank"> </span>-i<span class="blank"> </span>l<span class="blank _0"> </span>(A)</span></span></div><div class="t m1 x14 h4 y86 ffb fs2 fc0 sc0 lsf ws28">e<span class="blank _f"> </span>Y<span class="blank _2"> </span>es<span class="blank _2"> </span>el<span class="blank _2"> </span>susti<span class="blank"> </span>t<span class="blank"> </span>uyente<span class="blank _2"> </span>d<span class="blank"> </span>i<span class="blank"> </span>m<span class="blank"> </span>eti<span class="blank"> </span>l<span class="blank"> </span>a<span class="blank"> </span>m<span class="blank"> </span>i<span class="blank"> </span>no<span class="blank"> </span>.</div><div class="t m1 x18 h4 yf9 ffb fs2 fc0 sc0 ls9">8</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pf9" class="pf w0 h0" data-page-no="9"><div class="pc pc9 w0 h0"><img fetchpriority="low" loading="lazy" class="bi x1d y196 w9 h2f" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bg9.png"><div class="t m1 x1a he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x1b hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x1c hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x1c hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x1c hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x1c hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x1c hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x1c hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x1c hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x1c hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x1c hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x1c hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x1c hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x14 h4 y51 ffb fs2 fc0 sc0 ls9 wsfb">La<span class="blank _4"> </span>segunda<span class="blank _9"> </span>mol´<span class="blank _5"></span><span class="ls8 ws82">ec<span class="blank _1c"></span>ula,<span class="blank"> </span>r<span class="blank _c"></span>epr<span class="blank _c"></span>es<span class="blank _1c"></span>en<span class="blank _c"></span>tada<span class="blank _9"> </span>como<span class="blank _2"> </span>eje<span class="blank _c"></span>mplo,<span class="blank"> </span>tiene<span class="blank"> </span>e<span class="blank _c"></span>l<span class="blank"> </span>nom<span class="blank _1c"></span>bre<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank"> </span>in<span class="blank _c"></span>v<span class="blank _c"></span>en<span class="blank _1c"></span>tor<span class="blank"> </span>GR<span class="blank _c"></span>QF<span class="blank _c"></span>-MN94b<span class="blank _2"> </span>y<span class="blank"> </span>el</span></div><div class="t m1 x1d h4 yc6 ffb fs2 fc0 sc0 lsf ws58">nomb<span class="blank"> </span>re<span class="blank _f"> </span>sistem<span class="blank _3"> </span>´<span class="blank _5"></span><span class="ls2d ws39">atico<span class="blank _f"> </span>de<span class="blank _2"> </span>\u201cdibro<span class="blank"> </span>muro<span class="blank _12"> </span>de<span class="blank _f"> </span>1<span class="blank"> </span>,<span class="blank"> </span>1<span class="blank"> </span>\u2019<span class="blank"> </span>-[<span class="blank"> </span>Pro<span class="blank"> </span>pano<span class="blank"> </span>-1,<span class="blank"> </span>3-bis(feni<span class="blank"> </span>l<span class="blank"> </span>-4-meti<span class="blank"> </span>l)]-bis(4-pi<span class="blank"> </span>rro<span class="blank"> </span>l<span class="blank"> </span>idinopiridi<span class="blank"> </span>nio),<span class="blank _12"> </span>que</span></div><div class="t m1 x1d h14 yc7 ffb fs2 fc0 sc0 ls2d ws57">responde<span class="blank _f"> </span>tambi´<span class="blank _5"></span><span class="ls53 ws10a">e<span class="blank _19"></span>nal<span class="blank _18"></span>a\u201c<span class="blank _18"></span>F<span class="blank _19"></span>´<span class="blank _1e"></span><span class="ls1c ws10b">ormu<span class="blank _c"></span>la<span class="blank"> </span>a<span class="ws76 v0">\u201d,<span class="blank"> </span>en<span class="blank"> </span>la<span class="blank"> </span>qu<span class="blank _c"></span>e<span class="blank"> </span>n=3,<span class="blank"> </span>el<span class="blank"> </span>s<span class="blank _c"></span>us<span class="blank _c"></span>titu<span class="blank _c"></span>y<span class="blank _c"></span>en<span class="blank _1c"></span>te<span class="blank _f"> </span>X<span class="blank"> </span>co<span class="blank _c"></span>rre<span class="blank _1c"></span>sponde<span class="blank"> </span>al<span class="blank"> </span>grupo<span class="blank _f"> </span>A<span class="blank _0"> </span>(1-p<span class="blank _c"></span>iridin<span class="blank _c"></span>io-</span></span></span></div><div class="t m1 x1d h4 y197 ffb fs2 fc0 sc0 ls1c wsfe">1-il)<span class="blank _12"> </span>y<span class="blank _1"></span>,<span class="blank"> </span>\ufb01nalme<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _c"></span>,<span class="blank"> </span>Y<span class="blank"> </span>est<span class="blank _c"></span>´<span class="blank _1b"></span><span class="ls8 ws50">a<span class="blank _2"> </span>repr<span class="blank _c"></span>es<span class="blank _1c"></span>en<span class="blank _c"></span>tado<span class="blank _2"> </span>p<span class="blank"> </span>or<span class="blank _2"> </span>e<span class="blank _c"></span>l<span class="blank _2"> </span>gr<span class="blank _c"></span>upo<span class="blank _f"> </span>pirr<span class="blank _c"></span>olidino.</span></div><div class="t m1 x14 h4 y198 ffb fs2 fc0 sc0 ls2d ws1d">Los<span class="blank _f"> </span>compuestos<span class="blank"> </span>represe<span class="blank _c"></span>ntados<span class="blank"> </span>son<span class="blank"> </span>s´<span class="blank _1b"></span><span class="ls8 ws4c">olo<span class="blank"> </span>eje<span class="blank _1c"></span>mplos<span class="blank"> </span>de<span class="blank"> </span>comp<span class="blank _c"></span>ues<span class="blank _1c"></span>tos<span class="blank _2"> </span>pert<span class="blank _c"></span>ene<span class="blank _1c"></span>cien<span class="blank _1c"></span>tes<span class="blank _2"> </span>a<span class="blank"> </span>la<span class="blank"> </span>pr<span class="blank _c"></span>imera<span class="blank"> </span>c<span class="blank _1c"></span>ategor<span class="blank _d"></span>´<span class="blank _a"></span><span class="lsb">\u0131a</span></span></div><div class="t m1 x1d h4 y199 ffb fs2 fc0 sc0 ls2f ws78">estructural<span class="blank _2"> </span>que<span class="blank"> </span>est´<span class="blank _1b"></span><span class="ls14 ws40">a<span class="blank _4"> </span>constituida<span class="blank _f"> </span>p<span class="blank _3"> </span>or<span class="blank _2"> </span>todos<span class="blank _2"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _f"> </span>compuestos<span class="blank _2"> </span>que<span class="blank _f"> </span>se<span class="blank _2"> </span>deriv<span class="blank _1c"></span>a<span class="blank"> </span>n<span class="blank _f"> </span>de<span class="blank _2"> </span>to<span class="blank _3"> </span>das</span></div><div class="t m1 x1d h4 y19a ffb fs2 fc0 sc0 ls1c wsd2">las<span class="blank"> </span>posible<span class="blank _c"></span>s<span class="blank"> </span>comb<span class="blank _c"></span>inac<span class="blank _c"></span>iones<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _2"> </span>los<span class="blank"> </span>e<span class="blank _c"></span>leme<span class="blank _c"></span>n<span class="blank _c"></span>tos<span class="blank"> </span>es<span class="blank _c"></span>tru<span class="blank _c"></span>ct<span class="blank _c"></span>urale<span class="blank _1c"></span>s<span class="blank _4"> </span>n,<span class="blank _2"> </span>X<span class="blank"> </span>(A,<span class="blank _2"> </span>B,<span class="blank"> </span>C<span class="blank _2"> </span>y<span class="blank"> </span>D)e<span class="blank _2"> </span>Y<span class="blank _2"> </span>de<span class="blank _c"></span>n<span class="blank _1c"></span>tro<span class="blank _2"> </span>de<span class="blank"> </span>la<span class="blank _2"> </span>\u201cF´<span class="blank _1b"></span>or<span class="blank _c"></span>mu<span class="blank _c"></span>la</div><div class="t m1 x1d h4 y19b ffb fs2 fc0 sc0 ls9">a</div><div class="t m1 x3b h4 y19c ffb fs2 fc0 sc0 ls10">\u201d.</div><div class="t m1 x14 h4 y19d ffb fs2 fc0 sc0 ls2d ws49">Los<span class="blank _20"> </span>com<span class="blank"> </span>puestos<span class="blank _0"> </span>pertenecien<span class="blank _c"></span>tes<span class="blank _f"> </span>a<span class="blank _20"> </span>la<span class="blank _0"> </span>segunda<span class="blank _20"> </span>catego<span class="blank"> </span>r<span class="blank _29"></span>´<span class="blank _a"></span>\u0131<span class="blank"> </span>a<span class="blank _0"> </span>estructural<span class="blank _0"> </span>v<span class="blank"> </span>i<span class="blank"> </span>enen<span class="blank _0"> </span>represe<span class="blank _c"></span>ntados<span class="blank _12"> </span>p<span class="blank _3"> </span>or<span class="blank _20"> </span>l<span class="blank"> </span>a<span class="blank _0"> </span>\u201cF´<span class="blank _1b"></span><span class="ls1c ws3a">orm<span class="blank _1c"></span>ula</span></div><div class="t m1 x1d h28 y19e ffb fs2 fc0 sc0 ls9 wse0">b<span class="v0">\u201d</span></div><div class="t m1 x1d h4 y19f ffb fs2 fc0 sc0 ls2d ws39">en<span class="blank _2"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>que<span class="blank _4"> </span>n<span class="blank _4"> </span>puede<span class="blank _4"> </span>ser<span class="blank _4"> </span>0,<span class="blank _8"> </span>1,<span class="blank _4"> </span>2,<span class="blank _4"> </span>3,<span class="blank _4"> </span>etc.<span class="blank _16"> </span>y<span class="blank _4"> </span>el<span class="blank _4"> </span>grup<span class="blank _3"> </span>o<span class="blank _4"> </span>X<span class="blank _4"> </span>puede<span class="blank _4"> </span>ser<span class="blank _4"> </span>cualqui<span class="blank"> </span>era<span class="blank _4"> </span>de<span class="blank _4"> </span>l<span class="blank"> </span>os<span class="blank _2"> </span>el<span class="blank"> </span>ementos<span class="blank _4"> </span>estructurales</div><div class="t m1 x1d h4 y1a0 ffb fs2 fc0 sc0 ls10 ws97">A,<span class="blank _4"> </span>B<span class="blank _c"></span>,<span class="blank"> </span>C,<span class="blank"> </span>D<span class="blank _2"> </span>y<span class="blank"> </span>E,<span class="blank"> </span>sie<span class="blank _c"></span>ndo,<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>c<span class="blank _c"></span>ada<span class="blank"> </span>cas<span class="blank _1c"></span>o,<span class="blank"> </span>Y<span class="blank"> </span>sus<span class="blank _c"></span>tituy<span class="blank _1c"></span>en<span class="blank _c"></span>tes<span class="blank"> </span>tales<span class="blank _2"> </span>como:<span class="blank _14"> </span>-H,<span class="blank"> </span>CH</div><div class="t m1 x3c h11 y1a1 ff5 fs5 fc0 sc0 ls0">3<span class="ffb fs2 lsb wsc5 v3">,-CH</span></div><div class="t m1 x33 h11 y1a1 ff5 fs5 fc0 sc0 ls0">2<span class="ffb fs2 ls32 ws104 v3">OH,<span class="blank"> </span>-CO-C<span class="blank _3"> </span>H</span><span class="ls2b">3<span class="ffb fs2 ls4e ws105 v3">,-<span class="blank _b"></span>C<span class="blank _b"></span>N<span class="blank _6"></span>,</span></span></div><div class="t m1 x1d h10 y1a2 ffb fs2 fc0 sc0 ls18 ws10c">-NH<span class="ff5 fs5 ls0 v6">2</span><span class="ls2d ws7b v0">,<span class="blank"> </span>-N(CH<span class="ff5 fs5 ls2b v6">3</span><span class="ls9 wse0">)<span class="ff5 fs5 ls2b v6">2</span><span class="ls14 ws40">,<span class="blank _4"> </span>pirroli<span class="blank"> </span>di<span class="blank"> </span>no<span class="blank"> </span>,<span class="blank _2"> </span>pi<span class="blank"> </span>p<span class="blank _3"> </span>eridino,<span class="blank _4"> </span>p<span class="blank _3"> </span>erhidroazepino,<span class="blank _4"> </span>-OH,<span class="blank _4"> </span>-O-CO-C</span></span></span></div><div class="t m1 x3d h11 y1a3 ff5 fs5 fc0 sc0 ls3e wsde">15<span class="ffb fs2 ls10 ws72 v3">5H</span>31<span class="blank"> </span><span class="ffb fs2 ls34 wsc7 v3">,e<span class="blank _b"></span>t<span class="blank _a"></span>c<span class="blank _b"></span>.<span class="blank _0"> </span>P<span class="blank _b"></span>o<span class="blank _b"></span>rs<span class="blank _b"></span>up<span class="blank _b"></span>a<span class="blank _a"></span>r<span class="blank _b"></span>t<span class="blank _a"></span>e<span class="blank _b"></span>,<span class="blank"> </span>l<span class="blank _a"></span>o<span class="blank _a"></span>s</span></div><div class="t m1 x1d h23 y1a4 ffb fs2 fc0 sc0 lsf ws28">susti<span class="blank"> </span>tu<span class="blank"> </span>yentes<span class="blank _2"> </span>R<span class="ff5 fs5 ls2b v6">1</span><span class="ls48 v0">,R</span></div><div class="t m1 x3e h11 y1a5 ff5 fs5 fc0 sc0 ls41">2<span class="ffb fs2 ls54 v3">yR</span></div><div class="t m1 x39 h11 y1a5 ff5 fs5 fc0 sc0 ls51">3<span class="ffb fs2 ls1c wsc1 v3">son<span class="blank _f"> </span>gru<span class="blank _c"></span>pos<span class="blank"> </span>alquilos,<span class="blank _12"> </span>tale<span class="blank _1c"></span>s<span class="blank"> </span>como<span class="blank"> </span>-<span class="blank _c"></span>Me,<span class="blank"> </span>-<span class="blank _c"></span>Et,<span class="blank"> </span>e<span class="blank _1c"></span>tc.,<span class="blank"> </span>aun<span class="blank _c"></span>que<span class="blank _c"></span>,<span class="blank"> </span>en<span class="blank"> </span>algun<span class="blank _c"></span>os<span class="blank _12"> </span>casos<span class="blank"> </span>R<span class="ff5 fs5 ls51 v6">2</span><span class="ls9">y</span></span></div><div class="t m1 x1d h10 y1a6 ffb fs2 fc0 sc0 ls52">R<span class="ff5 fs5 ls51 v6">3</span><span class="ls14 ws4d v0">pueden<span class="blank _2"> </span>se<span class="blank _c"></span>r<span class="blank _f"> </span>g<span class="blank"> </span>rup<span class="blank _3"> </span>os<span class="blank _2"> </span>m´<span class="blank _5"></span><span class="ls1c ws61">as<span class="blank"> </span>comp<span class="blank _c"></span>lejos<span class="blank _c"></span>,<span class="blank"> </span>tales<span class="blank"> </span>como<span class="blank _f"> </span>-CH</span></span></div><div class="t m1 x3f h11 y1a7 ff5 fs5 fc0 sc0 ls0">2<span class="ffb fs2 ls19 ws10d v3">-CH</span><span class="ls2b">2<span class="ffb fs2 ls32 ws1b v3">OH,<span class="blank"> </span>-CH</span></span>2<span class="ffb fs2 ls2f ws44 v3">-CH(OMe)</span><span class="ls2a">2<span class="ffb fs2 ls48 wse6 v3">,-<span class="blank _19"></span>C<span class="blank _e"></span>H</span></span></div><div class="t m1 x40 h11 y1a7 ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls1a ws99 v3">CH(OEt)</span><span class="ls2a">2<span class="ffb fs2 ls9 v3">.</span></span></div><div class="t m1 x14 h4 y1a8 ffb fs2 fc0 sc0 ls1e ws63">En<span class="blank"> </span>el<span class="blank"> </span>c<span class="blank _1c"></span>aso<span class="blank _f"> </span>par<span class="blank _1c"></span>ticular<span class="blank"> </span>qu<span class="blank _c"></span>e<span class="blank"> </span>se<span class="blank"> </span>pr<span class="blank _c"></span>es<span class="blank _c"></span>en<span class="blank _1c"></span>ta<span class="blank _f"> </span>cuan<span class="blank _c"></span>do<span class="blank"> </span>n<span class="blank"> </span>toma<span class="blank _0"> </span>el<span class="blank"> </span>v<span class="blank _1c"></span>alor<span class="blank _0"> </span>2,<span class="blank"> </span>ade<span class="blank _c"></span>m´<span class="blank _1b"></span><span class="ls14 ws40">as<span class="blank _f"> </span>de<span class="blank _0"> </span>lo<span class="blank"> </span>s<span class="blank _12"> </span>compuestos<span class="blank _f"> </span>que<span class="blank _12"> </span>resultan</span></div><div class="t m1 x1d h4 y1a9 ffb fs2 fc0 sc0 ls14 ws40">de<span class="blank _4"> </span>la<span class="blank _4"> </span>\u201cF´<span class="blank _5"></span><span class="ls1c ws7d">orm<span class="blank _c"></span>ula<span class="blank"> </span>b</span></div><div class="t m1 x41 h4 y1aa ffb fs2 fc0 sc0 ls2f ws49">\u201d,<span class="blank _8"> </span>se<span class="blank _4"> </span>han<span class="blank _8"> </span>preparado<span class="blank _8"> </span>ta<span class="blank"> </span>mbi´<span class="blank _5"></span>en<span class="blank _4"> </span>l<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _4"> </span>que<span class="blank _8"> </span>deriv<span class="blank _c"></span>an<span class="blank _4"> </span>de<span class="blank _8"> </span>la<span class="blank _4"> </span>estructura<span class="blank _9"> </span>de<span class="blank _4"> </span>cis-(Z<span class="blank _3"> </span><span class="ls1a ws4b">)<span class="blank _4"> </span>y<span class="blank _4"> </span>tra<span class="blank"> </span>ns-<span class="blank _9"> </span>(E<span class="ls9">)</span></span></div><div class="t m1 x1d h4 y1ab ffb fs2 fc0 sc0 ls1c wsd9">es<span class="blank _1c"></span>tilb<span class="blank _3"> </span>e<span class="blank _c"></span>nos<span class="blank"> </span>pro<span class="blank _1c"></span>vistos<span class="blank"> </span>d<span class="blank _c"></span>e<span class="blank _8"> </span>los<span class="blank"> </span>su<span class="blank _c"></span>stit<span class="blank _c"></span>uy<span class="blank _1c"></span>en<span class="blank _c"></span>te<span class="blank _c"></span>s<span class="blank _9"> </span>X<span class="blank"> </span>(modalidade<span class="blank _c"></span>s<span class="blank"> </span>A,<span class="blank"> </span>B,<span class="blank"> </span>C,<span class="blank"> </span>D<span class="blank _9"> </span>y<span class="blank"> </span>E)<span class="blank"> </span>e<span class="blank _8"> </span>Y<span class="blank"> </span>pre<span class="blank _c"></span>viame<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank"> </span>indicad<span class="blank _c"></span>os.</div><div class="t m1 x1d h4 y1ac ffb fs2 fc0 sc0 lsf ws58">Al<span class="blank"> </span>g<span class="blank"> </span>un<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>ej<span class="blank"> </span>em<span class="blank _3"> </span>pl<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _4"> </span>de<span class="blank _4"> </span>com<span class="blank"> </span>p<span class="blank"> </span>u<span class="blank"> </span>esto<span class="blank"> </span>s<span class="blank _8"> </span>p<span class="blank"> </span>ert<span class="blank"> </span>eneci<span class="blank _3"> </span>entes<span class="blank _9"> </span>a<span class="blank _4"> </span>la<span class="blank _4"> </span>\u201c<span class="blank"> </span>F<span class="blank"> </span>´<span class="blank _5"></span><span class="ls1c ws4f">ormu<span class="blank _c"></span>la<span class="blank"> </span>b</span></div><div class="t m1 x42 h4 y1ad ffb fs2 fc0 sc0 ls1e ws1c">\u201d<span class="blank"> </span>se<span class="blank"> </span>re<span class="blank _1c"></span>pres<span class="blank _c"></span>en<span class="blank _1c"></span>tan<span class="blank _8"> </span>a<span class="blank"> </span>con<span class="blank _1c"></span>tinu<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls10 wsb4">on<span class="blank"> </span>con<span class="blank"> </span>la</span></div><div class="t m1 x1d h4 y1ae ffb fs2 fc0 sc0 lsb wsc5">in<span class="blank _1c"></span>tenc<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls2f ws49">on<span class="blank _f"> </span>de<span class="blank _2"> </span>mo<span class="blank"> </span>strar<span class="blank _2"> </span>alg<span class="blank"> </span>una<span class="blank"> </span>s<span class="blank _f"> </span>estructuras<span class="blank _2"> </span>com<span class="blank"> </span>p<span class="blank"> </span>l<span class="blank"> </span>etas:</span></div><div class="t m1 x1f h4 y1af ffb fs2 fc0 sc0 ls9">9</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div> <div id="pfa" class="pf w0 h0" data-page-no="a"><div class="pc pca w0 h0"><img fetchpriority="low" loading="lazy" class="bi x14 y1b0 wa h30" alt="" src="https://files.passeidireto.com/787a2faa-25b5-4fed-bdcf-98987f2a7aa0/bga.png"><div class="t m1 x10 he y44 ffb fs8 fc0 sc0 ls26 ws36">ES<span class="blank"> </span>2<span class="blank"> </span>117<span class="blank _9"> </span>950<span class="blank"> </span>B<span class="blank _c"></span>1</div><div class="t m1 x0 hf y45 ffc fs9 fc0 sc0 ls9">5</div><div class="t m1 x11 hf y46 ffc fs9 fc0 sc0 ls2c">10</div><div class="t m1 x11 hf y47 ffc fs9 fc0 sc0 ls2c">15</div><div class="t m1 x11 hf y48 ffc fs9 fc0 sc0 ls2c">20</div><div class="t m1 x11 hf y49 ffc fs9 fc0 sc0 ls2c">25</div><div class="t m1 x11 hf y4a ffc fs9 fc0 sc0 ls2c">30</div><div class="t m1 x11 hf y4b ffc fs9 fc0 sc0 ls2c">35</div><div class="t m1 x11 hf y4c ffc fs9 fc0 sc0 ls2c">40</div><div class="t m1 x11 hf y4d ffc fs9 fc0 sc0 ls2c">45</div><div class="t m1 x11 hf y4e ffc fs9 fc0 sc0 ls2c">50</div><div class="t m1 x11 hf y4f ffc fs9 fc0 sc0 ls2c">55</div><div class="t m1 x11 hf y50 ffc fs9 fc0 sc0 ls2c">60</div><div class="t m1 x13 h4 y1b1 ffb fs2 fc0 sc0 ls31 ws46">El<span class="blank _12"> </span>co<span class="blank"> </span>m<span class="blank"> </span>p<span class="blank"> </span>uesto<span class="blank _f"> </span>G<span class="blank"> </span>RQF<span class="blank"> </span>-<span class="blank"> </span>FK3<span class="blank _f"> </span>es<span class="blank _12"> </span>un<span class="blank _f"> </span>deri<span class="blank"> </span>vado<span class="blank _12"> </span>de<span class="blank _f"> </span>la<span class="blank _12"> </span>est<span class="blank"> </span>ruct<span class="blank"> </span>ura<span class="blank _2"> </span>del<span class="blank _f"> </span>gru<span class="blank"> </span>p<span class="blank _3"> </span>o<span class="blank _12"> </span>4<span class="blank"> </span>-<span class="blank"> </span>(N<span class="lsb wsc5">,N<span class="ls1b ws10e">-dime<span class="blank _1c"></span>tilamino)p<span class="blank _c"></span>iridi<span class="blank _1c"></span>nio<span class="blank"> </span>(X</span></span></div><div class="t m1 x14 h4 y1b2 ffb fs2 fc0 sc0 ls55 ws10f">=g<span class="blank _e"></span>r<span class="blank _e"></span>u<span class="blank _19"></span>p<span class="blank _19"></span>oA<span class="blank _19"></span>;Y<span class="blank"> </span>=<span class="blank"> </span>-<span class="blank _19"></span>N<span class="blank _e"></span>M<span class="blank _e"></span>e</div><div class="t m1 x43 h11 y1b3 ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls2d ws4b v3">),<span class="blank _2"> </span>mientras<span class="blank _2"> </span>que<span class="blank _2"> </span>el<span class="blank _2"> </span>compuesto<span class="blank _2"> </span>GRQF-FK21<span class="blank _2"> </span>e<span class="blank _c"></span>s<span class="blank _2"> </span>un<span class="blank _2"> </span>derivado<span class="blank _f"> </span>del<span class="blank _2"> </span>grup<span class="blank _3"> </span>o<span class="blank _2"> </span>estructural</span></div><div class="t m1 x14 h4 y1b4 ffb fs2 fc0 sc0 ls1e wscd">3-hidro<span class="blank _1c"></span>xiquin<span class="blank _c"></span>uclid<span class="blank _c"></span>inio<span class="blank _0"> </span>(<span class="blank"> </span>X<span class="blank"> </span>=<span class="blank"> </span>D;<span class="blank"> </span>Y<span class="blank"> </span>=<span class="blank"> </span>-O<span class="blank _c"></span>H).<span class="blank"> </span>En<span class="blank"> </span>am<span class="blank _c"></span>bos<span class="blank"> </span>c<span class="blank _c"></span>asos<span class="blank _c"></span>,<span class="blank _2"> </span>el<span class="blank"> </span>v<span class="blank _1"></span>alor<span class="blank"> </span>de<span class="blank"> </span>n<span class="blank"> </span>e<span class="blank _c"></span>s<span class="blank"> </span>cer<span class="blank _c"></span>o.</div><div class="t m1 x13 h4 y1b5 ffb fs2 fc0 sc0 lsf ws58">Lo<span class="blank"> </span>s<span class="blank _12"> </span>com<span class="blank _3"> </span>puesto<span class="blank"> </span>s<span class="blank _f"> </span>p<span class="blank"> </span>ert<span class="blank"> </span>eneci<span class="blank"> </span>entes<span class="blank _2"> </span>a<span class="blank _12"> </span>l<span class="blank"> </span>a<span class="blank _12"> </span>tercera<span class="blank _2"> </span>catego<span class="blank"> </span>r<span class="blank _29"></span>´<span class="blank _e"></span><span class="ls2f ws16">\u0131a<span class="blank _12"> </span>estructural<span class="blank _f"> </span>vienen<span class="blank _12"> </span>represen<span class="blank _c"></span>tados<span class="blank _f"> </span>p<span class="blank _3"> </span>or<span class="blank _12"> </span>la<span class="blank _12"> </span>\u201c<span class="blank"> </span>F´<span class="blank _5"></span><span class="ls1c ws3a">orm<span class="blank _c"></span>ula</span></span></div><div class="t m1 x14 h4 y1b6 ffb fs2 fc0 sc0 ls9">c</div><div class="t m1 x34 h4 y1b7 ffb fs2 fc0 sc0 ls2d ws39">\u201d,<span class="blank _f"> </span>en<span class="blank _f"> </span>l<span class="blank"> </span>a<span class="blank _f"> </span>que<span class="blank _f"> </span>el<span class="blank _f"> </span>grup<span class="blank"> </span>o<span class="blank _2"> </span>X<span class="blank _f"> </span>puede<span class="blank _f"> </span>ser<span class="blank _2"> </span>cualquiera<span class="blank _f"> </span>de<span class="blank _f"> </span>lo<span class="blank"> </span>s<span class="blank _12"> </span>el<span class="blank"> </span>ementos<span class="blank _f"> </span>estructurales<span class="blank _2"> </span>ya<span class="blank _f"> </span>mencionados<span class="blank _f"> </span>con<span class="blank _f"> </span>anterio-</div><div class="t m1 x14 h4 y1b8 ffb fs2 fc0 sc0 ls1a ws4b">ridad<span class="blank _2"> </span>A,<span class="blank _2"> </span>B,<span class="blank _f"> </span>C<span class="blank _2"> </span>y<span class="blank _f"> </span>D<span class="blank"> </span>:</div><div class="t m1 x14 h4 y1b9 ffb fs2 fc0 sc0 ls1e wsd9">sie<span class="blank _c"></span>ndo,<span class="blank"> </span>e<span class="blank _c"></span>n<span class="blank"> </span>cada<span class="blank"> </span>c<span class="blank _c"></span>aso,<span class="blank"> </span>Y<span class="blank"> </span>su<span class="blank _c"></span>stit<span class="blank _c"></span>uy<span class="blank _c"></span>en<span class="blank _1c"></span>tes<span class="blank"> </span>tales<span class="blank"> </span>c<span class="blank _c"></span>omo:<span class="blank _13"> </span>-H,<span class="blank"> </span>CH</div><div class="t m1 x44 h11 y1ba ff5 fs5 fc0 sc0 ls0">3<span class="ffb fs2 lsb wsc5 v3">,-CH</span></div><div class="t m1 x36 h11 y1ba ff5 fs5 fc0 sc0 ls0">2<span class="ffb fs2 ls32 ws104 v3">OH,<span class="blank"> </span>-CO-C<span class="blank _3"> </span>H</span>3<span class="ffb fs2 ls4e ws105 v3">,-<span class="blank _b"></span>C<span class="blank _b"></span>N<span class="blank _6"></span>,<span class="blank _c"></span>-<span class="blank _b"></span>N<span class="blank _b"></span>H</span></div><div class="t m1 x37 h11 y1ba ff5 fs5 fc0 sc0 ls2b">2<span class="ffb fs2 ls2d ws7b v3">,<span class="blank"> </span>-N(CH</span>3<span class="ffb fs2 ls9 wse0 v3">)</span>2<span class="ffb fs2 ls9 v3">,</span></div><div class="t m1 x14 h4 y1bb ffb fs2 fc0 sc0 ls14 ws40">pirrol<span class="blank"> </span>i<span class="blank"> </span>di<span class="blank"> </span>no<span class="blank"> </span>,<span class="blank _4"> </span>pi<span class="blank"> </span>p<span class="blank _3"> </span>eridino,<span class="blank _8"> </span>p<span class="blank _3"> </span>erhidroazepino,<span class="blank _9"> </span>-OH,<span class="blank _8"> </span>-O-CO-C</div><div class="t m1 x9 h11 y1bc ff5 fs5 fc0 sc0 ls3e wsde">15<span class="ffb fs2 ls9 wse0 v3">H</span>31<span class="blank"> </span><span class="ffb fs2 ls31 ws46 v3">,<span class="blank _9"> </span>etc.<span class="blank _28"> </span>P<span class="blank _c"></span>or<span class="blank _8"> </span>su<span class="blank _9"> </span>parte,<span class="blank _7"> </span>el<span class="blank _8"> </span>susti<span class="blank _3"> </span>tuyente<span class="blank _8"> </span>g<span class="blank"> </span>en<span class="blank"> </span>e-</span></div><div class="t m1 x14 h4 y1bd ffb fs2 fc0 sc0 ls1c ws88">ral<span class="blank _8"> </span>denomin<span class="blank _c"></span>ado<span class="blank _8"> </span>Z<span class="blank _9"> </span>se<span class="blank _9"> </span>de<span class="blank _1c"></span>\ufb01ne<span class="blank _9"> </span>como<span class="blank _9"> </span>c<span class="blank _c"></span>ualquie<span class="blank _1c"></span>r<span class="blank _9"> </span>gru<span class="blank _c"></span>po<span class="blank _7"> </span>alquilo<span class="blank _4"> </span>(-M<span class="blank _c"></span>e,<span class="blank _7"> </span>-E<span class="blank _c"></span>t,<span class="blank _7"> </span>etc<span class="blank _1c"></span>.)<span class="blank _26"> </span>ar<span class="blank _c"></span>ilo<span class="blank _8"> </span>(fe<span class="blank _c"></span>nilo,<span class="blank _9"> </span>e<span class="blank _c"></span>tc)<span class="blank _c"></span>,<span class="blank _13"> </span>grupos</div><div class="t m1 x14 h14 y1be ffb fs2 fc0 sc0 lsf ws28">elect<span class="blank"> </span>r´<span class="blank _5"></span><span class="ls9 ws9c">ondona<span class="blank _3"> </span>n<span class="blank _1c"></span>tes<span class="blank"> </span>(-OMe,<span class="blank"> </span>-NH<span class="ff5 fs5 ls2b v6">2</span><span class="ls48 wse6 v0">,N<span class="blank _e"></span>M<span class="blank _e"></span>e</span></span></div><div class="t m1 x1a h11 y1bf ff5 fs5 fc0 sc0 ls2a">2<span class="ffb fs2 ls2f wsc1 v3">,<span class="blank"> </span>etc).</span></div><div class="t m1 x13 h4 y1c0 ffb fs2 fc0 sc0 lsf ws58">Al<span class="blank"> </span>g<span class="blank"> </span>un<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>ej<span class="blank"> </span>em<span class="blank _3"> </span>pl<span class="blank"> </span>o<span class="blank"> </span>s<span class="blank _2"> </span>d<span class="blank"> </span>e<span class="blank _4"> </span>com<span class="blank"> </span>p<span class="blank"> </span>u<span class="blank"> </span>esto<span class="blank"> </span>s<span class="blank _4"> </span>p<span class="blank _3"> </span>erteneci<span class="blank"> </span>entes<span class="blank _8"> </span>a<span class="blank _4"> </span>l<span class="blank"> </span>a<span class="blank _4"> </span>\u201cF´<span class="blank _5"></span><span class="ls1c ws4f">ormu<span class="blank _c"></span>la<span class="blank"> </span>c</span></div><div class="t m1 x45 h4 y1c1 ffb fs2 fc0 sc0 ls1e wse1">\u201d<span class="blank"> </span>se<span class="blank"> </span>re<span class="blank _1c"></span>pres<span class="blank _c"></span>en<span class="blank _1c"></span>tan<span class="blank _8"> </span>a<span class="blank"> </span>con<span class="blank _1c"></span>tinu<span class="blank _c"></span>aci´<span class="blank _1b"></span><span class="ls10 wsca">on<span class="blank"> </span>con</span></div><div class="t m1 x14 h4 y1c2 ffb fs2 fc0 sc0 lsb ws25">la<span class="blank"> </span>in<span class="blank _1c"></span>tenc<span class="blank _1c"></span>i´<span class="blank _5"></span><span class="ls1e wsf7">on<span class="blank _8"> </span>de<span class="blank _8"> </span>mostr<span class="blank _c"></span>ar<span class="blank _8"> </span>algunas<span class="blank"> </span>e<span class="blank _c"></span>str<span class="blank _c"></span>uc<span class="blank _c"></span>tur<span class="blank _c"></span>as<span class="blank _7"> </span>comple<span class="blank _1c"></span>tas.<span class="blank _15"> </span>Los<span class="blank _9"> </span>e<span class="blank _c"></span>jemp<span class="blank _c"></span>los<span class="blank"> </span>rep<span class="blank _c"></span>re<span class="blank _c"></span>se<span class="blank _c"></span>n<span class="blank _c"></span>tados<span class="blank _c"></span>,<span class="blank _7"> </span>GRQF-M<span class="blank _c"></span>N98b<span class="blank"> </span>y</span></div><div class="t m1 x14 h4 y1c3 ffb fs2 fc0 sc0 ls8 ws85">GRQ<span class="blank _c"></span>F-MN<span class="blank _c"></span>164b<span class="blank _20"> </span>mue<span class="blank _1c"></span>stran<span class="blank"> </span>la<span class="blank"> </span>ve<span class="blank _c"></span>rs<span class="blank _c"></span>atilidad<span class="blank"> </span>de<span class="blank"> </span>las<span class="blank"> </span>es<span class="blank _c"></span>tru<span class="blank _c"></span>ctu<span class="blank _c"></span>ras<span class="blank _12"> </span>corr<span class="blank _c"></span>es<span class="blank _1c"></span>p<span class="blank _3"> </span>ondie<span class="blank _c"></span>n<span class="blank _c"></span>te<span class="blank _c"></span>s<span class="blank _f"> </span>a<span class="blank _12"> </span>la<span class="blank"> </span>\u201cF´<span class="blank _1b"></span><span class="ls1c ws10b">orm<span class="blank _1c"></span>ula<span class="blank"> </span>c</span></div><div class="t m1 x46 h4 y1c4 ffb fs2 fc0 sc0 lsf ws58">\u201d:<span class="blank _8"> </span>el<span class="blank _12"> </span>p<span class="blank"> </span>ri<span class="blank"> </span>m<span class="blank"> </span>ero</div><div class="t m1 x14 h4 y1c5 ffb fs2 fc0 sc0 lsc ws38">es<span class="blank _2"> </span>un</div><div class="t m1 x47 h4 y1af ffb fs2 fc0 sc0 ls10">10</div></div><div class="pi" data-data="{"ctm":[1.000000,0.000000,0.000000,1.000000,0.000000,0.000000]}"></div></div>
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